Genómica Comparativa del Desarrollo Vegetal

Marcelo J. Yanovsky - Fundación Instituto Leloir

idioma:

Nuestro laboratorio trabaja en la comprensión de las bases genéticas que median el control del ajuste del crecimiento y desarrollo de las plantas a su entorno. Principalmente, en la regulación del splicing alternativo sobre el reloj biológico. Para ello se combinan aproximaciones genómicas, moleculares y fisiológicas.

ClockSanchez, et. al. Elife (2013).

Fig2Perez-Santángelo, et al. Brief Funct Genomics (2013).

En Construcción

Mancini, E., Sanchez, S. E., Romanowski, A., Schlaen, R. G., Sanchez‐Lamas, M., Cerdán, P. D., & Yanovsky, M. J.Acute Effects of Light on Alternative Splicing in Light‐Grown Plants. Photochemistry and photobiology (2016) 92(1), 126-133. PubMed

Schlaen RG, Mancini E, Sanchez SE, Perez-Santángelo S, Rugnone ML, Simpson CG, Brown JW, Zhang X, Chernomoretz A, Yanovsky MJ. The spliceosome assembly factor GEMIN2 attenuates the effects of temperature on alternative splicing and circadian rhythms. Proc Natl Acad Sci USA (2015) V 112 p.9382-9387. PubMed

Romanowski A, Yanovsky MJ. Circadian rhythms and post-transcriptional regulation in higher plants. Frontiers in Plant Science (2015). Vol 6 p.437. PubMed

Hernando, Carlos E;  Sanchez, Sabrina E;  Mancini, Estefanía;  Yanovsky, Marcelo J. Genome wide comparative analysis of the effects of PRMT5 and PRMT4/CARM1 arginine methyltransferases on the Arabidopsis thaliana transcriptome. BMC genomics (2015). Vol 16 p. 192. PubMed

Perez-Santángelo S, Mancini E, Francey LJ, Schlaen RG, Chernomoretz A, Hogenesch JB, Yanovsky MJ. Role for LSM genes in the regulation of circadian rhythms. Proc Natl Acad Sci USA (2014). 111(42):15166-71. PubMed

Beckwith EJ, Yanovsky MJ. Circadian regulation of gene expression: at the crossroads of transcriptional and post-transcriptional regulatory networks. Curr Opin Genet Dev. (2014). 27:35-42. PubMed

Rugnone ML, Faigón Soverna A, Sanchez SE, Schlaen RG, Hernando CE, Seymour DK, Mancini E, Chernomoretz A, Weigel D, Más P, Yanovsky MJ (2013). LNK genes integrate light and clock signaling networks at the core of the Arabidopsis oscillator. Proc Natl Acad Sci USA (2013). 110(29):12120-5. PubMed

Sanchez SE, Yanovsky MJ. Time for a change. Elife (2013). 2:e00791. Review. PubMed

Perez-Santángelo S, Schlaen RG, Yanovsky MJ. Genomic analysis reveals novel connections between alternative splicing and circadian regulatory networks. Brief Funct Genomics (2013). (1):13-24. Review. PubMed

Sanchez SE, Petrillo E, Kornblihtt AR, Yanovsky MJ. Alternative splicing at the right time. RNA Biol. (2011). 8(6):954-9. Review. PubMed

Sánchez SE, Petrillo E, Beckwith EJ, Zhang Xu, Rugnone ML, Hernando CE, Cuevas J, Godoy Herz MA, Depetris-Chauvin A, Simpson CG, Brown JWS, Cerdán PD, Borevitz JO, Mas P, Ceriani MF, Kornblihtt AR & Yanovsky MJ. A methyl transferase links the circadian clock to the regulation of alternative splicing. Nature (2010). 468, 112-116. PubMed

Más P, Yanovsky MJ. Time for circadian rhythms: plants get synchronized. Curr Opin Plant Biol. (2009). (5):574-9. Review. PubMed

Faigón-Soverna A, Harmon FG, Storani L, Karayekov E, Staneloni RJ, Gassmann W, Más P, Casal JJ, Kay SA, Yanovsky MJ. A constitutive shade-avoidance mutant implicates TIR-NBS-LRR proteins in Arabidopsis photomorphogenic development. Plant Cell (2006). (11):2919-2928. PubMed.

Yanovsky MJ, Kay SA. Living by the calendar: how plants know when to flower. Nat Rev Mol Cell Biol. (2003). (4):265-75. Review. PubMed

Yanovsky, M.J., Kay, S.A. Molecular basis of seasonal time measurement in Arabidopsis. Nature (2002). 419(6904):308-12. PubMed





Dr. Marcelo Yanovsky
Director del grupo. Investigador Principal CONICET - myanovsky@leloir.org.ar



Dr. Santiago Mora Garcia
Investigador Adjunto CONICET - smora@leloir.org.ar



Dra. Julieta Mateos
Investigadora Asistente CONICET - jmateos@leloir.org.ar



Dra. Carolina Garcia
Becaria Postdoctoral CONICET - cgarcia@leloir.org.ar



Dr. Andrés Romanowski
Becario Postdoctoral Fundación Bunge y Born - aromanowski@leloir.org.ar



Dr. Carlos Esteban Hernando
Becario Postdoctoral Fundación Bunge y Born - chernando@leloir.org.ar



Dra. Soledad Pérez Santángelo
Becaria Doctoral CONICET - sperez@leloir.org.ar



Lic. Estefanía Mancini
Becaria Doctoral ANPCyT - emancini@leloir.org.ar



Lic. María José De Leone
Becaria Doctoral CONICET - mjdeleone@leloir.org.ar



Joaquin Casal
Estudiante de Licenciatura - jfcasal@leloir.org.ar



Dr. Esteban Beckwith
Ex-Becario Posdoctoral Fundación Bunge y Born - ebeckwith@leloir.org.ar



Dr. Gustavo Schlaen
Ex-Becario Postdoctoral Fundación Bunge y Born - rschlaen@leloir.org.ar



Dra. Ana Faigón Soverna
Ex-Becaria Post-Doctoral.



Dra. Sabrina Sanchez
Ex-Becaria Post-Doctoral.



Dr. Matias Rugnone
Ex-Becario Doctoral.



Lic. Martina Legris
Ex-Estudiante de Licenciatura



Lic. Fransisco Astigueta
Ex-Estudiante de Licenciatura