Bertolin AP, Gottifredi V. A mitotic stopwatch determines cell fate. Science. 2024 383(6690):1414-1415.doi: 10.1126/science.ado5703.   Pubmed Comment

Castaño BA, Schorer S, Guo Y, Calzetta NL, Gottifredi V, Wiesmüller L, Biber S. The levels of p53 govern the hierarchy of DNA damage tolerance pathway usage. Nucleic Acids Research. 2024. 52(7):3740-3760 https://doi.org/10.1093/nar/gkae061      Pubmed

Jahjah T, Singh JK, Gottifredi V, Quinet A. Tolerating DNA damage by repriming: Gap filling in the spotlight. DNA Repair (Amst). 2024 Aug 30;142:103758. https://doi.org/10.1016/j.dnarep.2024.103758 Research article      Pubmed

Montero L, Okraine YV, Orlowski J, Matzkin S, Scarponi I, Miranda MV, Nusblat A, Gottifredi V, Alonso LG. Conserved cysteine-switches for redox sensing operate in the Cyclin-Dependent Kinase Inhibitor p21(CIP/KIP) Protein Family. Free radical biology & medicine. 2024 224:494-505. https://doi.org/10.1016/j.freeradbiomed.2024.09.013  Research article      Pubmed

Guantay L, Garro C, Siri S, Pansa MF, Ghidelli-Disse S, Paviolo N, Racca A, Nicotra V, Radu C, Bocco JL, Felice R, Jansson KH, Remlinger K, Amador A, Stronach E, Coleman K, Muelbaier M, Drewes G, Gloger I, Madauss K, García M, Gottifredi V, Soria G. Deoxycytidine kinase (dCK) inhibition is synthetic lethal with BRCA2 deficiency. Drug Resist Updat. 67:100932 2023.. doi: 10.1016/j.drup.2023.100932.      PubMed

Mansilla SF, Bertolin AP, Venerus Arbilla S, Castaño BA, Jahjah T, Singh JK, Siri SO, Castro MV, de la Vega MB, Quinet A, Wiesmüller L, Gottifredi V. Polymerase iota (Pol ι) prevents PrimPol-mediated nascent DNA synthesis and chromosome instability. Sci Adv. 9(15):eade7997 2023.. doi: 10.1126/sciadv.ade7997.      PubMed

Martino J, Siri SO, Calzetta NL, Paviolo NS, Garro C, Pansa MF, Carbajosa S, Brown AC, Bocco JL, Gloger I, Drewes G, Madauss KP, Soria G, Gottifredi V. Inhibitors of Rho kinases (ROCK) induce multiple mitotic defects and synthetic lethality in BRCA2-deficient cells. Elife. 12:e80254 2023.. doi: 10.7554/eLife.80254.      PubMed

Calzetta NL, Besteiro MAG, Gottifredi V. PARP activity fine-tunes the DNA replication choreography of Chk1-depleted cells. J Mol Biol. 433(10):166949 2021.. doi: 10.1016/j.jmb.2021.166949.      PubMed

Ihle M, Biber S, Schroeder IS, Blattner C, Deniz M, Damia G, Gottifredi V, Wiesmüller L. Impact of the interplay between stemness features, p53 and pol iota on replication pathway choices. Nucleic Acids Res. 49(13):7457-7475 2021.. doi: 10.1093/nar/gkab526.      PubMed

Siri SO, Martino J, Gottifredi V. Structural Chromosome Instability: Types, Origins, Consequences, and Therapeutic Opportunities. Cancers. 13(12):3056 2021.. doi: 10.3390/cancers13123056.      PubMed      Review

Bertolin AP, Hoffmann JS, Gottifredi V. Under-Replicated DNA: The Byproduct of Large Genomes? Cancers (Basel). (10):E2764 2020.. doi: 10.3390/cancers12102764.      PubMed      Review

Biber S, Pospiech H, Gottifredi V, Wiesmüller L. Multiple biochemical properties of the p53 molecule contribute to activation of polymerase iota-dependent DNA damage tolerance. Nucleic Acids Res. 48(21):12188-12203 2020.. doi: 10.1093/nar/gkaa974.      PubMed

Calzetta NL, Besteiro MAG, Gottifredi V. Mus81-Eme1-dependent aberrant processing of DNA replication intermediates in mitosis impairs genome integrity. Sci Adv. 6(50):eabc8257 2020.. doi: 10.1126/sciadv.abc8257.       PubMed

Federico MB, Siri SO, Calzetta NL, Paviolo NS, de la Vega MB, Martino J, Campana MC, Wiesmüller L, Gottifredi V. Unscheduled MRE11 activity triggers cell death but not chromosome instability in polymerase eta-depleted cells subjected to UV irradiation. Oncogene. 39(19):3952-3964 2020.. doi: 10.1038/s41388-020-1265-9.      PubMed

Gottifredi V. Targeting DNA damage response kinases in cancer therapy. Mutat Res. 821:111725 2020.. doi: 10.1016/j.mrfmmm.2020.111725.      PubMed