Ciclo Celular y Estabilidad Genómica English version

Calzetta NL, González Besteiro MA*, Gottifredi V*. Mus81-Eme1-dependent aberrant processing of DNA replication intermediates in mitosis impairs genome integrity. (*corresponding authors). Sci Adv. 2020 Dec 9;6(50): eabc8257. doi: 10.1126/sciadv.abc8257. Print 2020 Dec. IF-13,1.

Biber S, Pospiech H, Gottifredi V, Wiesmüller L. Multiple biochemical properties of the p53 molecule contribute to activation of polymerase iota-dependent DNA damage tolerance. Nucleic Acids Res. 2020 Dec 2;48(21):12188-12203. doi: 10.1093/nar/gkaa974. IF.11,5

Bertolin AP, Hoffmann JS, Gottifredi V. Under-Replicated DNA: The Byproduct of Large Genomes?. Cancers (Basel). 2020 Sep 25;12(10):2764. doi: 10.3390/cancers12102764. IF: 6,1

Federico MB, Siri SO, Calzetta NL, Paviolo NS, de la Vega MB, Martino J, Campana MC, Wiesmüller L, Gottifredi V. Unscheduled MRE11 activity triggers cell death but not chromosome instability in polymerase eta-depleted cells subjected to UV irradiation. Oncogene. 2020 May;39(19):3952-3964. doi: 10.1038/s41388-020-1265-9. Epub 2020 Mar 23. IF, 6,8.

González Besteiro MA, Calzetta NL, Loureiro S, Habif M, Bétous R, Pillaire MJ, Maffia A, Sabbioneda S, Hoffmann JS, Gottifredi V. Chk1 loss creates replication barriers that compromise cell survival independently of excess origin firing. EMBO Journal. 15;38(16):e101284. doi: 10.15252/embj.2018101284. (2019). IF.11,22.

Carbajosa S, Pansa MF, Paviolo NS, Castellaro AM, Andino DL, Nigra AD, García IA, Racca AC, Rodriguez-Berdini L, Angiolini V, Guantay L, Villafañez F, Federico MB, Rodríguez-Baili MC, Caputto BL, Drewes G, Madauss KP, Gloger I, Fernandez E, Gil GA, Bocco JL, Gottifredi V*, Soria G*. Polo-like Kinase 1 inhibition as a therapeutic approach to selectively target BRCA1-deficient cancer cells by synthetic lethality induction. (*corresponding authors). Clin Cancer Res. 2019 Mar 19. pii: clincanres.3516.2018. doi: 10.1158/1078-0432.CCR-18-3516. (2019) . IF: 10.19.

Mansilla SF, Bertolin AP, Bergoglio V, Pillaire MJ, González Besteiro MA, Luzzani C, Miriuka SG, Cazaux C, Hoffmann JS, Gottifredi V. Cyclin Kinase-independent role of p21CDKN1A in the promotion of nascent DNA elongation in unstressed cells. Elife. 5pii: e18020. doi: 10.7554/eLife.18020. (2016); IF 7,05.

Hampp S, Kiessling T, Buechle K, Mansilla SF, Thomale J, Rall M, Ahn J, Pospiech H, Gottifredi V, and Wiesmüller L. DNA damage tolerance pathway involving DNA polymerase ι and the tumor suppressor p53 regulates DNA replication fork progression. Proc Natl Acad Sci U S A.;113(30): E4311-9. doi: 10.1073/pnas.1605828113. (2016). IF 9,6

MB Federico, MB Vallerga, A Rald, NP Paviolo, JL Bocco, M Di Giorgio, G Soria, Gottifredi V. Chromosomal Integrity after UV Irradiation requires FANCD2-mediated Repair of Double Strand Breaks'.PLoS Genetics 12 (1), e1005792-e1005792. doi: 10.1371/journal.pgen.1005792. (2016). IF: 6,1.

Vallerga MB, Mansilla SF, Federico MB, Bertolin AP, Gottifredi V. Rad51 recombinase prevents Mre11 nuclease-dependent degradation and excessive primpol-mediated elongation of nascent DNA after UV irradiation. . Proc Natl Acad Sci USA. 112 (48), E6624-E6633. doi: 10.1073/pnas.1508543112. Epub 2015 Nov 16. IF: 9,6.