Cáncer
Guantay L, Garro C, Siri S, Pansa MF, Ghidelli-Disse S, Paviolo N, Racca A, Nicotra V, Radu C, Bocco JL, Felice R, Jansson KH, Remlinger K, Amador A, Stronach E, Coleman K, Muelbaier M, Drewes G, Gloger I, Madauss K, García M, Gottifredi V, Soria G. Deoxycytidine kinase (dCK) inhibition is synthetic lethal with BRCA2 deficiency. Drug Resist Updat. 67:100932 (2023). doi: 10.1016/j.drup.2023.100932. PubMed
Mansilla SF, Bertolin AP, Venerus Arbilla S, Castaño BA, Jahjah T, Singh JK, Siri SO, Castro MV, de la Vega MB, Quinet A, Wiesmüller L, Gottifredi V. Polymerase iota (Pol ι) prevents PrimPol-mediated nascent DNA synthesis and chromosome instability. Sci Adv. 9(15):eade7997 (2023). doi: 10.1126/sciadv.ade7997. PubMed
Martino J, Siri SO, Calzetta NL, Paviolo NS, Garro C, Pansa MF, Carbajosa S, Brown AC, Bocco JL, Gloger I, Drewes G, Madauss KP, Soria G, Gottifredi V. Inhibitors of Rho kinases (ROCK) induce multiple mitotic defects and synthetic lethality in BRCA2-deficient cells. Elife. 12:e80254 (2023). doi: 10.7554/eLife.80254. PubMed
Calzetta NL, Besteiro MAG, Gottifredi V. PARP activity fine-tunes the DNA replication choreography of Chk1-depleted cells. J Mol Biol. 433(10):166949 (2021). doi: 10.1016/j.jmb.2021.166949. PubMed
Ihle M, Biber S, Schroeder IS, Blattner C, Deniz M, Damia G, Gottifredi V, Wiesmüller L. Impact of the interplay between stemness features, p53 and pol iota on replication pathway choices. Nucleic Acids Res. 49(13):7457-7475 (2021). doi: 10.1093/nar/gkab526. PubMed
Siri SO, Martino J, Gottifredi V. Structural Chromosome Instability: Types, Origins, Consequences, and Therapeutic Opportunities. Cancers. 13(12):3056 (2021). doi: 10.3390/cancers13123056. PubMed Review
Bertolin AP, Hoffmann JS, Gottifredi V. Under-Replicated DNA: The Byproduct of Large Genomes? Cancers (Basel). (10):E2764 (2020). doi: 10.3390/cancers12102764. PubMed Review
Biber S, Pospiech H, Gottifredi V, Wiesmüller L. Multiple biochemical properties of the p53 molecule contribute to activation of polymerase iota-dependent DNA damage tolerance. Nucleic Acids Res. 48(21):12188-12203 (2020). doi: 10.1093/nar/gkaa974. PubMed
Calzetta NL, Besteiro MAG, Gottifredi V. Mus81-Eme1-dependent aberrant processing of DNA replication intermediates in mitosis impairs genome integrity. Sci Adv. 6(50):eabc8257 (2020). doi: 10.1126/sciadv.abc8257. PubMed
Federico MB, Siri SO, Calzetta NL, Paviolo NS, de la Vega MB, Martino J, Campana MC, Wiesmüller L, Gottifredi V. Unscheduled MRE11 activity triggers cell death but not chromosome instability in polymerase eta-depleted cells subjected to UV irradiation. Oncogene. 39(19):3952-3964 (2020). doi: 10.1038/s41388-020-1265-9. PubMed
Gottifredi V. Targeting DNA damage response kinases in cancer therapy. Mutat Res. 821:111725 (2020). doi: 10.1016/j.mrfmmm.2020.111725. PubMed
Gottifredi V, Wiesmüller L. Current Understanding of RAD52 Functions: Fundamental and Therapeutic Insights. Cancers (Basel). 12(3):705 (2020). doi: 10.3390/cancers12030705. PubMed Editorial
Mansilla SF, de la Vega MB, Calzetta NL, Siri SO, Gottifredi V. CDK-Independent and PCNA-Dependent Functions of p21 in DNA Replication. Genes (Basel). 11(6):593 (2020). doi: 10.3390/genes11060593. PubMed Review
Paviolo NS, Vega MB, Pansa MF, García IA, Calzetta NL, Soria G, Gottifredi V. Persistent double strand break accumulation does not precede cell death in an Olaparib-sensitive BRCA-deficient colorectal cancer cell model. Genet Mol Biol. 43(1 suppl 1):e20190070 (2020). doi: 10.1590/1678-4685-GMB-2019-0070. PubMed
Carbajosa S, Pansa MF, Paviolo NS, Castellaro AM, Andino DL, Nigra AD, García IA, Racca AC, Rodriguez-Berdini L, Angiolini V, Guantay L, Villafañez F, Federico MB, Rodríguez-Baili MC, Caputto BL, Drewes G, Madauss KP, Gloger I, Fernandez E, Gil GA, Bocco JL, Gottifredi V, Soria G. Polo-like Kinase 1 inhibition as a therapeutic approach to selectively target BRCA1-deficient cancer cells by synthetic lethality induction. Clin Cancer Res. 25(13):4049-4062 (2019). doi: 10.1158/1078-0432.CCR-18-3516. PubMed