Neurociencias
Dalmasso MC, de Rojas I, Olivar N, Muchnik C, Angel B, Gloger S, Sanchez Abalos MS, Chacón MV, Aránguiz R, Orellana P, Cuesta C, Galeano P, Campanelli L, Novack GV, Martinez LE, Medel N, Lisso J, Sevillano Z, Irureta N, Castaño EM, Montrreal L, Thoenes M, Hanses C, Heilmann-Heimbach S, Kairiyama C, Mintz I, Villella I, Rueda F, Romero A, Wukitsevits N, Quiroga I, Gona C, Lambert JC, Solis P, Politis DG, Mangone CA, Gonzalez-Billault C, Boada M, Tàrraga L, Slachevsky A, Albala C, Fuentes P, Kochen S, Brusco LI, Ruiz A, Morelli L, Ramírez A. The first genome-wide association study in the Argentinian and Chilean populations identifies shared genetics with Europeans in Alzheimer’s disease. Alzheimer’s & Dementia?: The Journal of the Alzheimer’s Association. 2024. 20(2), 1298–1308. https://doi.org/10.1002/alz.13522 Pubmed
Medina-Vera D, López-Gambero AJ, Verheul-Campos J, Navarro JA, Morelli L, Galeano P, Suárez J, Sanjuan C, Pacheco-Sánchez B, Rivera P, Pavón-Morón FJ, Rosell-Valle C, Fonseca FR. Therapeutic Efficacy of the Inositol D-Pinitol as a Multi-Faceted Disease Modifier in the 5×FAD Humanized Mouse Model of Alzheimer's Amyloidosis. Nutrients. 2024 Dec 4;16(23):4186. https://doi.org/10.3390/nu16234186 Research article Pubmed
Galeano P, de Ceglia M, Mastrogiovanni M, Campanelli L, Medina-Vera D, Campolo N, Novack GV, Rosell-Valle C, Suárez J, Aicardo A, Campuzano K, Castaño EM, Do Carmo S, Cuello AC, Bartesaghi S, Radi R, Rodríguez de Fonseca F, Morelli L. The Effect of Fat Intake with Increased Omega-6-to-Omega-3 Polyunsaturated Fatty Acid Ratio in Animal Models of Early and Late Alzheimer's Disease-like Pathogenesis. International Journal of Molecular Science Nov 30;24(23):17009. 2023. doi: 10.3390/ijms242317009. PubMed
Dalmasso MC, Arán M, Galeano P, Perin S, Giavalisco P, Martino Adami PV, Novack GV, Castaño EM, Cuello AC, Scherer M, Maier W, Wagner M, Riedel-Heller S, Ramirez A, Morelli L. Nicotinamide as potential biomarker for Alzheimer's disease: A translational study based on metabolomics. Front Mol Biosci. 9:1067296 2023.. doi: 10.3389/fmolb.2022.1067296. PubMed
Ruiz-Viroga V, de Ceglia M, Morelli L, Castaño EM, Calvo EB, Suárez J, de Fonseca FR, Galeano P, Lagos P. Acute intrahippocampal administration of melanin-concentrating hormone impairs memory consolidation and decreases the expression of MCHR-1 and TrkB receptors. Prog Neuropsychopharmacol Biol Psychiatry. 123:110703 2023.. doi: 10.1016/j.pnpbp.2022.110703. PubMed
Dalmasso MC, Arán M, Galeano P, Perin S, Giavalisco P, Martino Adami PV, Novack GV, Castaño EM, Cuello AC, Scherer M, Maier W, Wagner M, Riedel-Heller S, Ramirez A, Morelli L. Nicotinamide as potential biomarker for Alzheimer's disease: A translational study based on metabolomics. Front Mol Biosci. 9:1067296 2023.. doi: 10.3389/fmolb.2022.1067296. PubMed
Ruiz-Viroga V, de Ceglia M, Morelli L, Castaño EM, Calvo EB, Suárez J, de Fonseca FR, Galeano P, Lagos P. Acute intrahippocampal administration of melanin-concentrating hormone impairs memory consolidation and decreases the expression of MCHR-1 and TrkB receptors. Prog Neuropsychopharmacol Biol Psychiatry. 123:110703 2023.. doi: 10.1016/j.pnpbp.2022.110703. PubMed
Bellenguez C, et EADB Group (Castaño EM, Morelli L). New insights into the genetic etiology of Alzheimer's disease and related dementias. Nat Genet. 54(4):412-436 2022.. doi: 10.1038/s41588-022-01024-z. PubMed
de Rojas I, EADB contributors, The GR@ACE study group, DEGESCO consortium, IGAP, PGC-ALZ consortia, et al. Common variants in Alzheimer's disease and risk stratification by polygenic risk scores. Nat Commun. 12(1):3417 2021.. doi: 10.1038/s41467-021-22491-8. PubMed
Novack GV, Galeano P, Castaño EM, Morelli L. Mitochondrial Supercomplexes: Physiological Organization and Dysregulation in Age-Related Neurodegenerative Disorders. Front Endocrinol. 11:600 2020.. doi: 10.3389/fendo.2020.00600. PubMed
Bocai NI, Marcora MS, Belfiori-Carrasco LF, Morelli L, Castaño EM. Endoplasmic Reticulum Stress in Tauopathies: Contrasting Human Brain Pathology with Cellular and Animal Models. J Alzheimers Dis. ;68(2):439-458 2019.. doi: 10.3233/JAD-181021. PubMed
Dalmasso MC, Brusco LI, Olivar N, Muchnik C, Hanses C, Milz E, Becker J, Heilmann-Heimbach S, Hoffmann P, Prestia FA, Galeano P, Avalos MSS, Martinez LE, Carulla ME, Azurmendi PJ, Liberczuk C, Fezza C, Sampaño M, Fierens M, Jemar G, Solis P, Medel N, Lisso J, Sevillano Z, Bosco P, Bossù P, Spalletta G, Galimberti D, Mancuso M, Nacmias B, Sorbi S, Mecocci P, Pilotto A, Caffarra P, Panza F, Bullido M, Clarimon J, Sánchez-Juan P, Coto E, Sanchez-Garcia F, Graff C, Ingelsson M, Bellenguez C, Castaño EM, Kairiyama C, Politis DG, Kochen S, Scaro H, Maier W, Jessen F, Mangone CA, Lambert JC, Morelli L, Ramirez A. Transethnic meta-analysis of rare coding variants in PLCG2, ABI3, and TREM2 supports their general contribution to Alzheimer's disease. Transl Psychiatry. 9(1):55 2019.. doi: 10.1038/s41398-019-0394-9. PubMed
Martino Adami PV, Nichtová Z, Weaver DB, Bartok A, Wisniewski T, Jones DR, Do Carmo S, Castaño EM, Cuello AC, Hajnóczky G, Morelli L. Perturbed mitochondria-ER contacts in live neurons modelling Alzheimer's disease amyloid pathology. J Cell Sci. 132(20). pii: jcs229906 2019.. doi: 10.1242/jcs.229906. PubMed
Prestia FA, Galeano P, Martino Adami PV, Do Carmo S, Castaño EM, Cuello AC, Morelli L. Platelets Bioenergetics Screening Reflects the Impact of Brain Aβ Plaque Accumulation in a Rat Model of Alzheimer. Neurochem Res. 44(6):1375-1386 2019.. doi:10.1007/s11064-018-2657-x. PubMed
Galeano P, Leal MC, Ferrari CC, Dalmasso MC, Martino Adami PV, Farías MI, Casabona JC, Puntel M, Do Carmo S, Smal C, Arán M, Castaño EM, Pitossi FJ, Cuello AC, Morelli L. Chronic Hippocampal Expression of Notch Intracellular Domain Induces Vascular Thickening, Reduces Glucose Availability, and Exacerbates Spatial Memory Deficits in a Rat Model of Early Alzheimer. Mol Neurobiol. 55(11):8637-8650 2018.. doi: 10.1007/s12035-018-1002-3. PubMed
Castelletto V, Ryumin P, Cramer R, Hamley IW, Taylor M, Allsop D, Reza M, Ruokolainen J, Arnold T, Hermida-Merino D, Garcia CI, Leal MC, Castaño E. Self-Assembly and Anti-Amyloid Cytotoxicity Activity of Amyloid beta Peptide Derivatives. Sci Rep. 7:43637 2017.. doi: 10.1038/srep43637. PubMed
Frenkel L, Muraro NI, Beltrán González AN, Marcora MS, Bernabó G, Hermann-Luibl C, Romero JI, Helfrich-Förster C, Castaño EM, Marino-Busjle C, Calvo DJ, Ceriani MF. Organization of Circadian Behavior Relies on Glycinergic Transmission. Cell Rep. 19:72-85 2017.. doi: 10.1016/j.celrep.2017.03.034. PubMed
Marcora MS, Belfiori-Carrasco LF, Bocai NI, Morelli L, Castaño EM. Amyloid-β42 clearance and neuroprotection mediated by X-box binding protein 1 signaling decline with aging in the Drosophila brain. Neurobiol Aging. 24;60:57-70 2017.. doi: 10.1016/j.neurobiolaging.2017.08.012. PubMed
Medina-Vera D, López-Gambero AJ, Verheul-Campos J, Navarro JA, Morelli L, Galeano P, Suárez J, Sanjuan C, Pacheco-Sánchez B, Rivera P, Pavón-Morón FJ, Rosell-Valle C, Fonseca FR. Therapeutic Efficacy of the Inositol D-Pinitol as a Multi-Faceted Disease Modifier in the 5×FAD Humanized Mouse Model of Alzheimer's Amyloidosis. Nutrients. 2024 Dec 4;16(23):4186. https://doi.org/10.3390/nu16234186 Research article Pubmed
Galeano P, de Ceglia M, Mastrogiovanni M, Campanelli L, Medina-Vera D, Campolo N, Novack GV, Rosell-Valle C, Suárez J, Aicardo A, Campuzano K, Castaño EM, Do Carmo S, Cuello AC, Bartesaghi S, Radi R, Rodríguez de Fonseca F, Morelli L. The Effect of Fat Intake with Increased Omega-6-to-Omega-3 Polyunsaturated Fatty Acid Ratio in Animal Models of Early and Late Alzheimer's Disease-like Pathogenesis. International Journal of Molecular Science Nov 30;24(23):17009. 2023. doi: 10.3390/ijms242317009. PubMed
Dalmasso MC, Arán M, Galeano P, Perin S, Giavalisco P, Martino Adami PV, Novack GV, Castaño EM, Cuello AC, Scherer M, Maier W, Wagner M, Riedel-Heller S, Ramirez A, Morelli L. Nicotinamide as potential biomarker for Alzheimer's disease: A translational study based on metabolomics. Front Mol Biosci. 9:1067296 2023.. doi: 10.3389/fmolb.2022.1067296. PubMed
Ruiz-Viroga V, de Ceglia M, Morelli L, Castaño EM, Calvo EB, Suárez J, de Fonseca FR, Galeano P, Lagos P. Acute intrahippocampal administration of melanin-concentrating hormone impairs memory consolidation and decreases the expression of MCHR-1 and TrkB receptors. Prog Neuropsychopharmacol Biol Psychiatry. 123:110703 2023.. doi: 10.1016/j.pnpbp.2022.110703. PubMed
Dalmasso MC, Arán M, Galeano P, Perin S, Giavalisco P, Martino Adami PV, Novack GV, Castaño EM, Cuello AC, Scherer M, Maier W, Wagner M, Riedel-Heller S, Ramirez A, Morelli L. Nicotinamide as potential biomarker for Alzheimer's disease: A translational study based on metabolomics. Front Mol Biosci. 9:1067296 2023.. doi: 10.3389/fmolb.2022.1067296. PubMed
Ruiz-Viroga V, de Ceglia M, Morelli L, Castaño EM, Calvo EB, Suárez J, de Fonseca FR, Galeano P, Lagos P. Acute intrahippocampal administration of melanin-concentrating hormone impairs memory consolidation and decreases the expression of MCHR-1 and TrkB receptors. Prog Neuropsychopharmacol Biol Psychiatry. 123:110703 2023.. doi: 10.1016/j.pnpbp.2022.110703. PubMed
Bellenguez C, et EADB Group (Castaño EM, Morelli L). New insights into the genetic etiology of Alzheimer's disease and related dementias. Nat Genet. 54(4):412-436 2022.. doi: 10.1038/s41588-022-01024-z. PubMed
de Rojas I, EADB contributors, The GR@ACE study group, DEGESCO consortium, IGAP, PGC-ALZ consortia, et al. Common variants in Alzheimer's disease and risk stratification by polygenic risk scores. Nat Commun. 12(1):3417 2021.. doi: 10.1038/s41467-021-22491-8. PubMed
Novack GV, Galeano P, Castaño EM, Morelli L. Mitochondrial Supercomplexes: Physiological Organization and Dysregulation in Age-Related Neurodegenerative Disorders. Front Endocrinol. 11:600 2020.. doi: 10.3389/fendo.2020.00600. PubMed
Bocai NI, Marcora MS, Belfiori-Carrasco LF, Morelli L, Castaño EM. Endoplasmic Reticulum Stress in Tauopathies: Contrasting Human Brain Pathology with Cellular and Animal Models. J Alzheimers Dis. ;68(2):439-458 2019.. doi: 10.3233/JAD-181021. PubMed
Dalmasso MC, Brusco LI, Olivar N, Muchnik C, Hanses C, Milz E, Becker J, Heilmann-Heimbach S, Hoffmann P, Prestia FA, Galeano P, Avalos MSS, Martinez LE, Carulla ME, Azurmendi PJ, Liberczuk C, Fezza C, Sampaño M, Fierens M, Jemar G, Solis P, Medel N, Lisso J, Sevillano Z, Bosco P, Bossù P, Spalletta G, Galimberti D, Mancuso M, Nacmias B, Sorbi S, Mecocci P, Pilotto A, Caffarra P, Panza F, Bullido M, Clarimon J, Sánchez-Juan P, Coto E, Sanchez-Garcia F, Graff C, Ingelsson M, Bellenguez C, Castaño EM, Kairiyama C, Politis DG, Kochen S, Scaro H, Maier W, Jessen F, Mangone CA, Lambert JC, Morelli L, Ramirez A. Transethnic meta-analysis of rare coding variants in PLCG2, ABI3, and TREM2 supports their general contribution to Alzheimer's disease. Transl Psychiatry. 9(1):55 2019.. doi: 10.1038/s41398-019-0394-9. PubMed
Martino Adami PV, Nichtová Z, Weaver DB, Bartok A, Wisniewski T, Jones DR, Do Carmo S, Castaño EM, Cuello AC, Hajnóczky G, Morelli L. Perturbed mitochondria-ER contacts in live neurons modelling Alzheimer's disease amyloid pathology. J Cell Sci. 132(20). pii: jcs229906 2019.. doi: 10.1242/jcs.229906. PubMed
Prestia FA, Galeano P, Martino Adami PV, Do Carmo S, Castaño EM, Cuello AC, Morelli L. Platelets Bioenergetics Screening Reflects the Impact of Brain Aβ Plaque Accumulation in a Rat Model of Alzheimer. Neurochem Res. 44(6):1375-1386 2019.. doi:10.1007/s11064-018-2657-x. PubMed
Galeano P, Leal MC, Ferrari CC, Dalmasso MC, Martino Adami PV, Farías MI, Casabona JC, Puntel M, Do Carmo S, Smal C, Arán M, Castaño EM, Pitossi FJ, Cuello AC, Morelli L. Chronic Hippocampal Expression of Notch Intracellular Domain Induces Vascular Thickening, Reduces Glucose Availability, and Exacerbates Spatial Memory Deficits in a Rat Model of Early Alzheimer. Mol Neurobiol. 55(11):8637-8650 2018.. doi: 10.1007/s12035-018-1002-3. PubMed
Castelletto V, Ryumin P, Cramer R, Hamley IW, Taylor M, Allsop D, Reza M, Ruokolainen J, Arnold T, Hermida-Merino D, Garcia CI, Leal MC, Castaño E. Self-Assembly and Anti-Amyloid Cytotoxicity Activity of Amyloid beta Peptide Derivatives. Sci Rep. 7:43637 2017.. doi: 10.1038/srep43637. PubMed
Frenkel L, Muraro NI, Beltrán González AN, Marcora MS, Bernabó G, Hermann-Luibl C, Romero JI, Helfrich-Förster C, Castaño EM, Marino-Busjle C, Calvo DJ, Ceriani MF. Organization of Circadian Behavior Relies on Glycinergic Transmission. Cell Rep. 19:72-85 2017.. doi: 10.1016/j.celrep.2017.03.034. PubMed
Marcora MS, Belfiori-Carrasco LF, Bocai NI, Morelli L, Castaño EM. Amyloid-β42 clearance and neuroprotection mediated by X-box binding protein 1 signaling decline with aging in the Drosophila brain. Neurobiol Aging. 24;60:57-70 2017.. doi: 10.1016/j.neurobiolaging.2017.08.012. PubMed