Biología Celular y del Desarrollo
Antonella Ríos
Es Lic. en Biotecnología de la Universidad Nacional de Quilmes (UNQ). Relizó su tesina de licenciatura en el Laboratorio del Dr. Mario Ermácora. Actualmente se encuentra cursando su fromación doctoral en el Laboratoro de Neurobiología Molecular y Celular en la Fundación Instituto Leloir bajo la dirección de la Dra Ledda en la Fundación Instituto Leloir con beca de CONICET. Su proyecto se centra en identificar moléculas que median los efectos de los factores neurotróficoss en los procesos de conectividad neuronal del sistema nervioso central y periférico.
Federicci F, Ledda F, Paratcha G. TDAG51 mediates negative signaling crosstalk between NGF/p75NTR-induced cell death and GDNF/RET-promoted survival in motor neuron-derived cells. Neurochemical Research 2025;50(4):257. https://doi.org/10.1007/s11064-025-04518-4 Research article PubMed
De Vincenti AP, Bonafina A, Ledda F, Paratcha G. Lrig1 regulates cell fate specification of glutamatergic neurons via FGF-driven Jak2/Stat3 signaling in cortical progenitors. Development. 2024;151(17):dev202879. https://doi.org/10.1242/dev.202879 Research article PubMed
Ferrero-Restelli F, Federicci F, Ledda F, Paratcha G. Sprouty4 at the crossroads of Trk neurotrophin receptor signaling suppression by glucocorticoids. Frontiers in Molecular Neuroscience. 2023;16:1090824. https://doi.org/10.3389/fnmol.2023.1090824 Research article PubMed
Houghton FM, Adams SE, Ríos AS, Masino L, Purkiss AG, Briggs DC, Ledda F, McDonald NQ. Architecture and regulation of a GDNF-GFRα1 synaptic adhesion assembly. Nature Communications. 2023;14(1):7551. https://doi.org/10.1038/s41467-023-43148-8 Research article PubMed
Ríos AS, De Vincenti AP, Casadei M, Aquino JB, Brumovsky PR, Paratcha G, Ledda F. Etv4 regulates nociception by controlling peptidergic sensory neuron development and peripheral tissue innervation. Development. 2022;149(16):dev200583. https://doi.org/10.1242/dev.200583 Research article PubMed
De Vincenti AP, Alsina FC, Ferrero-Restelli F, Hedman H, Ledda F, Paratcha G. Lrig1 and Lrig3 cooperate to control Ret receptor signaling, sensory axonal growth and epidermal innervation. Development. 2021;148(16):dev197020. https://doi.org/10.1242/dev.197020 Research article PubMed
Hita FJ, Bekinschtein P, Ledda F, Paratcha G. Leucine-rich repeats and immunoglobulin-like domains 1 deficiency affects hippocampal dendrite complexity and impairs cognitive function. Developmental Neurobiology. 2021;81(6):774-785. https://doi.org/10.1002/dneu.22840 Research article PubMed
Bonafina A, Paratcha G, Ledda F. Deciphering New Players in the Neurogenic Adult Hippocampal Niche. Frontiers in Cell and Developmental Biology. 2020;8:548. https://doi.org/10.3389/fcell.2020.00548 Review PubMed
Ferrero-Restelli F, Fontanet PA, De Vincenti AP, Falzone TL, Ledda F, Paratcha G. Tetraspanin1 promotes NGF signaling by controlling TrkA receptor proteostasis. Cellular and Molecular Life Sciences. 2020;77(11):2217-2233. https://doi.org/10.1007/s00018-019-03282-3 Research article PubMed
Ibáñez CF, Paratcha G, Ledda F. RET-independent signaling by GDNF ligands and GFRα receptors. Cell and Tissue Research. 2020;382(1):71-82. https://doi.org/10.1007/s00441-020-03261-2 Review PubMed
Bonafina A, Trinchero MF, Ríos AS, Bekinschtein P, Schinder AF, Paratcha G, Ledda F. GDNF and GFRα1 are required for proper integration of adult-born hippocampal neurons. Cell Reports. 2019;29(13):4308-4319.e4. https://doi.org/10.1007/s00441-020-03261-2 Research article PubMed
De Vincenti AP, Ríos AS, Paratcha G, Ledda F. Mechanisms That Modulate and Diversify BDNF Functions: Implications for Hippocampal Synaptic Plasticity. Frontiers in Cell Neuroscience. 2019;13:135. https://doi.org/10.3389/fncel.2019.00135 Review PubMed