Microbiología y Enfermedades Infecciosas
Rouco SO, Rodriguez PE, Miglietta EA, Rall P, Ledesma MMGL, Varese A, Pascuale CA, Ojeda DS, Mazzitelli B, Sanchez L, Ceballos A, Perez E, Geffner J, Miragaya Y, Rossi AH, Gamarnik AV. Heterologous booster response after inactivated virus BBIBP-CorV vaccination in older people. Lancet Infect Dis. 2022 Jun 28:S1473-3099(22)00427-3. doi: 10.1016/S1473-3099(22)00427-3. Epub ahead of print. PMID: 35777383; PMCID: PMC9239573.
Adler NS, Cababie LA, Sarto C, Cavasotto CN, Gebhard LG, Estrin DA, Gamarnik AV, Arrar M, Kaufman SB. Insights into the product release mechanism of dengue virus NS3 helicase. Nucleic Acids Res. 2022 Jun 23;50(12):6968–79. doi: 10.1093/nar/gkac473. Epub ahead of print. PMID: 35736223; PMCID: PMC9262617.
Sanchez L, Oviedo Rouco S, Pifano M, Ojeda DS, Pascuale CA, Mazzitelli B, Di Diego Garcia F, Gonzalez Lopez Ledesma MM, Rodriguez PE, Miglietta EA, Ceballos A, Rossi AH, Kreplak N, Geffner J, Gamarnik AV. Antibody durability at 1 year after Sputnik V vaccination. Lancet Infect Dis. 2022 May;22(5):589-590. doi: 10.1016/S1473-3099(22)00176-1. Epub 2022 Mar 16. PMID: 35305316; PMCID: PMC8926411.
Gonzalez Lopez Ledesma MM, Sanchez L, Ojeda DS, Oviedo Rouco S, Rossi AH, Varese A, Mazzitelli I, Pascuale CA, Miglietta EA, Rodríguez PE, Pallarés HM, Costa Navarro GS, Caramelo JJ, Rothlauf PW, Liu Z, Bloyet LM, Cornejo Pontelli M, Rasetto NB, Wenker SD, Ramis LY, Bialer MG, de Leone MJ, Hernando CE, Bianchimano L, Ríos AS, Treffinger Cienfuegos MS, Rodriguez García DR, Longueira Y, Laufer N, Alvarez D, Ceballos A, Ochoa V, Monzani C, Turk G, Salvatori M, Carradori J, Prost K, Rima A, Varela C, Ercole R, Toro RI, Gutierrez S, Zubieta M, Acuña D, Nabaes Jodar MS, Torres C, Mojsiejczuk L, Viegas M, Velazquez P, Testa C, Kreplak N, Yanovsky M, Whelan S, Geffner J, Pifano M, Gamarnik AV. Longitudinal Study after Sputnik V Vaccination Shows Durable SARS-CoV-2 Neutralizing Antibodies and Reduced Viral Variant Escape to Neutralization over Time. mBio. 2022 Jan 25;13(1):e0344221. doi: 10.1128/mbio.03442-21. Epub ahead of print. PMID: 35073758; PMCID: PMC8787469.
Sallaberry I, Luszczak A, Philipp N, Navarro GSC, Gabriel MV, Gratton E, Gamarnik AV, Estrada LC. In vivo pair correlation microscopy reveals dengue virus capsid protein nucleocytoplasmic bidirectional movement in mammalian infected cells. Sci Rep. 2021 Dec 24;11(1):24415. doi: 10.1038/s41598-021-03854-z. Erratum in: Sci Rep. 2022 Jul 5;12(1):11343. PMID: 34952906; PMCID: PMC8709865.
Gabriel MV, Sallaberry I, Costa Navarro GS, Gratton E, Gamarnik AV, Estrada LC. Dengue Virus Capsid-Protein Dynamics in Live Infected Cells Studied by Pair Correlation Analysis. Methods Mol Biol. 2022;2409:99-117. doi: 10.1007/978-1-0716-1879-0_8. PMID: 34709638.
Ambroggio EE, Costa Navarro GS, Pérez Socas LB, Bagatolli LA, Gamarnik AV. Dengue and Zika virus capsid proteins bind to membranes and self-assemble into liquid droplets with nucleic acids. J Biol Chem. 2021 Sep;297(3):101059. doi: 10.1016/j.jbc.2021.101059. Epub 2021 Aug 8. PMID: 34375636; PMCID: PMC8397897.
Rossi AH, Ojeda DS, Varese A, Sanchez L, Gonzalez Lopez Ledesma MM, Mazzitelli I, Alvarez Juliá A, Oviedo Rouco S, Pallarés HM, Costa Navarro GS, Rasetto NB, Garcia CI, Wenker SD, Ramis LY, Bialer MG, de Leone MJ, Hernando CE, Sosa S, Bianchimano L, Rios AS, Treffinger Cienfuegos MS, Caramelo JJ, Longueira Y, Laufer N, Alvarez DE, Carradori J, Pedrozza D, Rima A, Echegoyen C, Ercole R, Gelpi P, Marchetti S, Zubieta M, Docena G, Kreplak N, Yanovsky M, Geffner J, Pifano M, Gamarnik AV. Sputnik V vaccine elicits seroconversion and neutralizing capacity to SARS-CoV-2 after a single dose. Cell Rep Med. 2021 Aug 17;2(8):100359. doi: 10.1016/j.xcrm.2021.100359. Epub 2021 Jul 9. PMID: 34308389; PMCID: PMC8266543.
Ojeda DS, Gonzalez Lopez Ledesma MM, Pallarés HM, Costa Navarro GS, Sanchez L, Perazzi B, Villordo SM, Alvarez DE; BioBanco Working Group, Echavarria M, Oguntuyo KY, Stevens CS, Lee B, Carradori J, Caramelo JJ, Yanovsky MJ, Gamarnik AV. PLoS Pathog. 2021 Jan 14;17(1):e1009161. doi: 10.1371/journal.ppat.1009161. Emergency response for evaluating SARS-CoV-2 immune status, seroprevalence and convalescent plasma in Argentina.
Oguntuyo KY, Stevens CS, Hung CT, Ikegame S, Acklin JA, Kowdle, Carmichael JC, Chiu HP, Azarm KD, Haas GD, Amanat F, Klingler J, Baine I, Arinsburg S, Bandres JC, Siddiquey MNA, Schilke RM, Woolard MD, Zhang H; COVIDAR Argentina Consortium, Duty AJ, Kraus TA, Moran TM, Tortorella D, Lim JK, Gamarnik AV, Hioe CE, Zolla-Pazner S, Ivanov SS, Kamil JP, Krammer F, Lee B. MBio. 2021 Feb 16;12(1):e02492-20. doi: 10.1128/mBio.02492-20. Quantifying Absolute Neutralization Titers against SARS-CoV-2 by a Standardized Virus Neutralization Assay Allows for Cross-Cohort Comparisons of COVID-19 Sera.
Simonovich VA, Burgos Pratx LD, Scibona P, Beruto MV, Vallone MG, Vázquez C, Savoy N, Giunta DH, Pérez LG, Sánchez MDL, Gamarnik AV, Ojeda DS, Santoro DM, Camino PJ, Antelo S, Rainero K, Vidiella GP, Miyazaki EA, Cornistein W, Trabadelo OA, Ross FM, Spotti M, Funtowicz G, Scordo WE, Losso MH, Ferniot I, Pardo PE, Rodriguez E, Rucci P, Pasquali J, Fuentes NA, Esperatti M, Speroni GA, Nannini EC, Matteaccio A, Michelangelo HG, Follmann D, Lane HC, Belloso WH; N Engl J Med. 2021 Feb 18;384(7):619-629. doi: 10.1056/NEJMoa2031304. Epub 2020 Nov 24. PlasmAr Study Group. A Randomized Trial of Convalescent Plasma in Covid-19 Severe Pneumonia.
Pagotto, Luna, Salto, Wagner Manslau, Silvana Figar, Alicia Mistchenko, G. Carciofi Boyero, N. Weinberger, COVIDAR Group. AM Gómez Saldaño, C. Alpire Alponte, P. Auza Alarcón, A. Copa Tarqui, S. Cortez, P. Gallardo, J. Gemio Pinaya, A. Hernandez Navarro, A. Maccio, P. Mosqueda, Nicole Neme, B. Quispe, Ramírez Bernal, T. Soria, Fernández Arce, AV Gamarnik, Fernán González Bernaldo de Quirós Long-Term Duration of Antibody Response to SARS CoV-2 in One of the Largest Slums of Buenos Aires. https://doi.org/10.1101/2021.03.05.21253010doi: medRxiv
Pallarés HM, Costa Navarro GS, Villordo SM, Merwaiss F, de Borba L, Gonzalez Lopez Ledesma MM, Ojeda DS, Henrion-Lacritick A, Morales MA, Fabri C, Saleh MC, Gamarnik AV. Zika Virus Subgenomic Flavivirus RNA Generation Requires Cooperativity between Duplicated RNA Structures That Are Essential for Productive Infection in Human Cells. J Virol. 2020 Aug 31;94(18):e00343-20. doi: 10.1128/JVI.00343-20.
Gabriel M, Navarro GSC, de Borba L, Rossi AH, Gamarnik AV, Estrada LC. Dengue Virus Capsid Protein Dynamics Reveals Spatially Heterogeneous Motion in Live-Infected-Cells. Sci Rep. 2020 May 29;10(1):8751. doi: 10.1038/s41598-020-65625-6.
Pozzi B, Bragado L, Mammi P, Torti MF, Gaioli N, Gebhard LG, García Solá ME, Vaz-Drago R, Iglesias NG, García CC, Gamarnik AV, Dengue virus targets RBM10 deregulating host cell splicing and innate immune response. Srebrow A. Nucleic Acids Res. 2020 May 20:gkaa340. doi: 10.1093/nar/gkaa340
de Borba L, Villordo SM, Marsico FL, Carballeda JM, Filomatori CV, Gebhard LG, Pallarés HM, Lequime S, Lambrechts L, Sánchez Vargas I, Blair CD, Gamarnik AV. RNA structure duplication in the dengue virus 3’UTR: redundancy or host specificity? MBio. 2019, 10:e02506-18.
Leal E, Adler N, Fernández G, Gebhard L, Battini L, Aucar M, Videla M, Monge M, Hernández de Los Ríos A, Acosta Dávila J, Morell M, Cordo S, García C, Gamarnik A, Cavasotto C, Bollini M. De novo design approaches targeting an envelope protein pocket to identify small molecules against dengue virus. Eur J Med Chem. 2019 Aug 15;182:111628. doi: 10.1016/j.ejmech.2019.111628.
Cababie L, Incicco J, González-Lebrero R, Roman E, Gebhard L, Gamarnik A, Kaufman S Thermodynamic study of the effect of ions on the interaction between dengue virus NS3 helicase and single stranded RNA. . Sci Rep. 2019 Jul 22;9(1):10569. doi: 10.1038/s41598-019-46741-4.
P, Link N, Jang G, Sharp P, Zhu T, Swaney D, Johnson JR, Von Dollen J, Ramage HR, Satkamp L, Newton B, Hüttenhain R, Petit M, Baum T, Everitt A, Laufman O, Tassetto M, Shales M, Stevenson E, Iglesias G, Shokat L, Tripathi S, Balasubramaniam V, Webb L, Aguirre S, Willsey AJ, Garcia-Sastre A, Pollard K, Cherry S, Gamarnik A, Marazzi I, Taunton J, Fernandez-Sesma A, Bellen H, Andino R, Krogan N Comparative Flavivirus-Host Protein Interaction Mapping Reveals Mechanisms of Dengue and Zika Virus Pathogenesis. Shah . Cell. 2018 Dec 13;175(7):1931-1945.e18. doi: 10.1016/j.cell.2018.11.028
Filomatori CV, Carballeda JM, Villordo SM, Aguirre S, Pallarés HM, Maestre AM, Sánchez-Vargas I, Blair CD, Fabri C, Morales MA, Fernandez-Sesma A, Gamarnik AV Dengue virus genomic variation associated with mosquito adaptation defines the pattern of viral non-coding RNAs and fitness in human cells. . PLoS Pathog. 2017 Mar 6;13(3):e1006265.
De Maio FA, Risso G, Iglesias NG, Shah P, Pozzi B, Gebhard LG, Mammi P, Mancini E, Yanovsky MJ, Andino R, Krogan N, Srebrow A, Gamarnik AV The Dengue Virus NS5 Protein Intrudes in the Cellular Spliceosome and Modulates Splicing.. PLoS Pathog. 2016 Aug 30;12(8):e1005841.
Byk LA, Gamarnik AV Properties and Functions of the Dengue Virus Capsid Protein. . Annu Rev Virol. 2016 Sep 29;3(1):263-281
Byk LA, Iglesias NG, De Maio FA, Gebhard LG, Rossi M, Gamarnik AV. ???????Dengue Virus Genome Uncoating Requires Ubiquitination. MBio. 2016 Jun 28;7(3). pii: e00804-16.
Gebhard LG, Iglesias NG, Byk LA, Filomatori CV, De Maio FA, Gamarnik AV A Proline-Rich N-Terminal Region of the Dengue Virus NS3 Is Crucial for Infectious Particle Production. . J Virol. 2016 May 12;90(11):5451-61.
Villordo SM, Carballeda JM, Filomatori CV, Gamarnik AV. RNA Structure Duplications and Flavivirus Host Adaptation. Trends Microbiol. 2016 Apr;24(4):270-283.
Heaton NS, Moshkina N, Fenouil R, Gardner TJ, Aguirre S, Shah PS, Zhao N, Manganaro L, Hultquist JF, Noel J, Sachs D, Hamilton J, Leon PE, Chawdury A, Tripathi S, Melegari C, Campisi L, Hai R, Metreveli G, Gamarnik AV, García-Sastre A, Greenbaum B, Simon V, Fernandez-Sesma A, Krogan NJ, Mulder LC, van Bakel H, Tortorella D, Taunton J, Palese P Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection. , Marazzi Immunity. 2016 Jan 19;44(1):46-58.
Iglesias NG, Mondotte JA, Byk LA, De Maio FA, Samsa MM, Alvarez C, Gamarnik AV Dengue Virus Uses a Non-Canonical Function of the Host GBF1-Arf-COPI System for Capsid Protein Accumulation on Lipid Droplets.. Traffic. 2015 Sep;16(9):962-77.
Villordo SM, Filomatori CV, Sánchez-Vargas I, Blair CD, Gamarnik AV Dengue virus RNA structure specialization facilitates host adaptation. . PLoS Pathog. 2015 Jan 30;11(1):e1004604.
de Borba L, Villordo SM, Iglesias NG, Filomatori CV, Gebhard LG, Gamarnik AV Overlapping local and long-range RNA-RNA interactions modulate dengue virus genome cyclization and replication. . J Virol. 2015 Mar;89(6):3430-7.
Gebhard LG, Incicco JJ, Smal C, Gallo M, Gamarnik AV, Kaufman SB. Monomeric nature of dengue virus NS3 helicase and thermodynamic analysis of the interaction with single-stranded RNA. Nucleic Acids Res. 2014 Oct;42(18):11668-86.
Villordo SM, Gamarnik AV Differential RNA sequence requirement for dengue virus replication in mosquito and mammalian cells. . J Virol. 2013 Aug;87(16):9365-72. doi: 10.1128/JVI.00567-13.
Gebhard LG, Kaufman SB, Gamarnik AV. Novel ATP-independent RNA annealing activity of the dengue virus NS3 helicase. PLoS One. 2012; 7(4):e36244. doi: 10.1371/journal.pone.0036244.
Samsa MM, Mondotte JA, Caramelo JJ, Gamarnik AV. Uncoupling cis-Acting RNA elements from coding sequences revealed a requirement of the N-terminal region of dengue virus capsid protein in virus particle formation. J Virol. 2012 Jan;86(2):1046-58. doi: 10.1128/JVI.05431-11.
Gebhard LG, Filomatori CV, Gamarnik AV. Functional RNA elements in the dengue virus genome. Viruses. 2011 Sep;3(9):1739-56. doi: 10.3390/v3091739.
Iglesias NG, Filomatori CV, Gamarnik AV The F1 motif of dengue virus polymerase NS5 is involved in promoter-dependent RNA synthesis. . J Virol. 2011 Jun;85(12):5745-56. doi: 10.1128/JVI.02343-10.
Iglesias NG, Gamarnik AV. Dynamic RNA structures in the dengue virus genome. RNA Biol. 2011 Mar-Apr;8(2):249-57. doi: 10.4161/rna.8.2.14992.
Filomatori CV, Iglesias NG, Villordo SM, Alvarez DE, Gamarnik AV RNA sequences and structures required for the recruitment and activity of the dengue virus polymerase. . J Biol Chem. 2011 Mar 4;286(9):6929-39. doi: 10.1074/jbc.M110.162289.
Villordo SM, Alvarez DE, Gamarnik AV A balance between circular and linear forms of the dengue virus genome is crucial for viral replication. . RNA. 2010 Dec;16(12):2325-35. doi: 10.1261/rna.2120410.
Samsa MM, Mondotte JA, Iglesias NG, Assunção-Miranda I, Barbosa-Lima G, Da Poian AT, Bozza PT, Gamarnik AV. Dengue virus capsid protein usurps lipid droplets for viral particle formation. PLoS Pathog. 2009 Oct;5(10):e1000632. doi: 10.1371/journal.ppat.1000632.
Lodeiro MF, Filomatori CV, Gamarnik AV Structural and functional studies of the promoter element for dengue virus RNA replication. . J Virol. 2009 Jan;83(2):993-1008. doi: 10.1128/JVI.01647-08.
Alvarez DE, Filomatori CV, Gamarnik AV Functional analysis of dengue virus cyclization sequences located at the 5' and 3'UTRs. . Virology. 2008 May 25;375(1):223-35. doi: 10.1016/j.virol.2008.01.014.
Mondotte JA, Lozach PY, Amara A, Gamarnik AV. Essential role of dengue virus envelope protein N glycosylation at asparagine-67 during viral propagation. J Virol. 2007 Jul;81(13):7136-48. doi: 10.1128/JVI.00116-07.
Alvarez DE, Lodeiro MF, Filomatori CV, Fucito S, Mondotte JA, Gamarnik AV Structural and functional analysis of dengue virus RNA. . Novartis Found Symp. 2006; 277:120-32; discussion 132-5, 251-3.
Filomatori CV, Lodeiro MF, Alvarez DE, Samsa MM, Pietrasanta L, Gamarnik AV. A 5' RNA element promotes dengue virus RNA synthesis on a circular genome. Genes Dev. 2006 Aug 15;20(16):2238-49. doi: 10.1101/gad.1444206.
Alvarez DE, De Lella Ezcurra AL, Fucito S, Gamarnik AV. Role of RNA structures present at the 3'UTR of dengue virus on translation, RNA synthesis, and viral replication. Virology. 2005 Sep 1;339(2):200-12. doi: 10.1016/j.virol.2005.06.009.
Alvarez DE, Lodeiro MF, Ludueña SJ, Pietrasanta LI, Gamarnik AV Long-range RNA-RNA interactions circularize the dengue virus genome. . J Virol. 2005 Jun;79(11):6631-43. doi: 10.1128/JVI.79.11.6631-6643.2005.