Neurodegenerative diseases such as Parkinson’s Disease (PD) and Multiple Sclerosis have a major impact in human health and their incidence is increasing as life expectancy growths. However, there are no current treatments that could slow down the death of the neurons causing disease symptoms or regenerate the functional loss caused by neuronal demise. Our laboratory tries to identify molecular targets for new treatments to protect the remaining brain neurons by studying the role of neuroinflammation on neuronal death. In this respect, after functional genomics studies on 5 animal models on inflammation-mediated PD developed by our lab, we have identified Plasma membrane calcium ATPase 1 (PMCA1) as a candidate neuroprotective molecule. In addition, in order to contribute to current efforts on achieving a regenerative therapy for Parkinson ‘s Disease, we seek to increase the survival of pluripotent stem cell derived-neurons after brain transplantation by modulating tumor necrosis factor alpha (TNF) function, a key molecule in the host inflammatory response. Finally, we have identified several candidate neuroprotective molecules after a proteomic analysis of inflammation-mediated MS animal models, previously generated in the lab.