Precise development of neuronal connections is crucial for proper nervous system function, and aberrant connectivity is linked to a variety of neurological disorders and neurodegenerative diseases. Moreover, the mechanisms underlying neuronal regeneration following degenerative processes share many cellular and molecular events with those governing axonal growth and nervous system innervation during development. Therefore, understanding the principles that govern the proper establishment and maintenance of synaptic contacts will aid in developing effective treatments for various pathologies affecting the nervous system. Our research focuses on elucidating the mechanisms by which signaling pathways activated by neurotrophic factors regulate neuronal migration, differentiation, axon guidance, dendritic growth, synaptic maturation, and neuronal plasticity during nervous system development and maturation. To this end, we employ diverse molecular, cellular, biochemical, and physiological approaches, including cell culture techniques, RNA sequencing (RNA-seq), confocal microscopy, and behavioral assays.