To understand viral replication and its interactions with the host, our lab employs a multidisciplinary approach combining virology, molecular biology, genomics, and proteomics. We use virus models such as Bunyamwera virus (BUNV, family Peribunyaviridae) and Prospect Hill virus (PHV, family Hantaviridae), which enable us to conduct research at biosafety level 2. We then validate and extend our findings using pathogenic viruses. Our lab also utilizes reverse genetics to investigate bunyaviral replication and to develop novel tools—such as viral tagging—for in vitro studies. Additionally, we have customized various RNA-seq methods to address fundamental questions about virus-host interactions.
In parallel, we are committed to developing antiviral countermeasures. In collaboration with partners, we isolate monoclonal antibodies from hybridomas and from the immune responses of individuals previously infected with viruses. We characterize these antibodies to gain insight into their mechanisms of action, the viral replication process, and their potential as therapeutic agents.