Neurons in the mammalian brain are a diverse and heterogenous population, critical to the execution of the most sophisticated functions. Their diversity underlies the complexity of the cerebral function, as well as distinct susceptibilities to disease and neurodevelopmental disorders. Our lab is interested in understanding how the collection of different excitatory neurons in the cerebral cortex are generated and how their specificity is established. To address this big and fundamental question we are first focusing on inter and extracellular mechanisms. In one of our new projects we have identified that different classes of neurons express distinct extracellular matrix (ECM) genes and modifiers. We are working to characterize this specificity and its role in the establishment of neuronal identity and the correct neuronal circuits. Given that some of these genes have been associated to neurodevelopmental disorders, such as Autism Spectrum Disorder (ASD), we will also study cell type-specific production of ECM in the context of ASD models. We use the laboratory mouse as our main model system, as it shares with humans most of the processes and cell types occurring during development. We are now incorporating in vitro models of human brain development (organoids), as well as work with human samples to complement and validate our work. Our approaches combine the use of classic and solid developmental neuroscience tools with the use of high-throughput single cell genomics.