{"id":1362,"date":"2026-07-01T10:00:01","date_gmt":"2026-07-01T13:00:01","guid":{"rendered":"https:\/\/www.leloir.org.ar\/research\/?page_id=1362"},"modified":"2026-07-08T09:32:25","modified_gmt":"2026-07-08T12:32:25","slug":"neuronal-plasticity","status":"publish","type":"page","link":"https:\/\/www.leloir.org.ar\/research\/neuronal-plasticity\/","title":{"rendered":"neuronal plasticity"},"content":{"rendered":"\n<div class=\"wp-block-stackable-spacer stk-block-spacer stk--no-padding stk-block stk-5bf724e\" data-block-id=\"5bf724e\"><style>.stk-5bf724e {height:20px !important;}<\/style><\/div>\n\n\n\n<div class=\"wp-block-greenshift-blocks-container alignfull gspb_container gspb_container-gsbp-c15c419\" id=\"gspb_container-id-gsbp-c15c419\">\n<div class=\"wp-block-greenshift-blocks-row gspb_row gspb_row-id-gsbp-18a8bbc\" id=\"gspb_row-id-gsbp-18a8bbc\"><div class=\"gspb_row__content\"> \n<div class=\"wp-block-greenshift-blocks-row-column gspb_row__col--6 gspb_row__col--xs-9 gspb_col-id-gsbp-1de9e8b\" id=\"gspb_col-id-gsbp-1de9e8b\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-fe81fce\" id=\"strong-research-area-strong\" data-block-id=\"fe81fce\"><style>.stk-fe81fce .stk-block-heading__text{color:var(--theme-palette-color-3, #a7a04d) !important;}@media screen and (max-width:689px){.stk-fe81fce {padding-bottom:0px !important;margin-bottom:0px !important;}}<\/style><h6 class=\"stk-block-heading__text has-text-color\"><strong>Research area<\/strong><\/h6><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-f5d6339\" id=\"strong-research-area-strong\" data-block-id=\"f5d6339\"><style>@media screen and (max-width:689px){.stk-f5d6339 {align-items:flex-start !important;padding-top:0px !important;padding-right:0px !important;padding-bottom:0px !important;padding-left:0px !important;margin-bottom:0px !important;display:flex !important;}}<\/style><h5 class=\"stk-block-heading__text has-text-align-left-mobile\"><strong><strong><strong><strong>Neuroscience<\/strong><\/strong><\/strong><\/strong><\/h5><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-greenshift-blocks-row-column gspb_row__col--6 gspb_row__col--xs-3 gspb_col-id-gsbp-643144c\" id=\"gspb_col-id-gsbp-643144c\">\n<div class=\"wp-block-stackable-image stk-block-image stk-block stk-aaae08c\" data-block-id=\"aaae08c\"><style>@media screen and (max-width:689px){.stk-aaae08c .stk-img-wrapper{width:80% !important;}}<\/style><figure><span class=\"stk-img-wrapper stk-image--shape-stretch\"><img loading=\"lazy\" decoding=\"async\" class=\"stk-img wp-image-1066\" src=\"https:\/\/www.leloir.org.ar\/research\/wp-content\/uploads\/2026\/06\/neuro.png\" width=\"100\" height=\"100\"\/><\/span><\/figure><\/div>\n<\/div>\n <\/div><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-stackable-columns alignfull stk-block-columns stk--hide-mobile stk-block stk-efbfbbe\" data-block-id=\"efbfbbe\"><style>.stk-efbfbbe {margin-bottom:0px !important;top:0px !important;left:0px !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-efbfbbe-column alignfull\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-095be29 stk-block-background\" data-v=\"4\" data-block-id=\"095be29\"><style>.stk-095be29-container{margin-top:var(--stk--preset--spacing--none, 0px) !important;margin-right:var(--stk--preset--spacing--none, 0px) !important;margin-bottom:var(--stk--preset--spacing--none, 0px) !important;margin-left:var(--stk--preset--spacing--none, 0px) !important;min-height:var(--stk--preset--block-height--none, 0px) !important;}.stk-095be29 {align-self:center !important;background-color:var(--theme-palette-color-1, #164193) !important;border-top-right-radius:var(--stk--preset--border-radius--full, 9999px) !important;border-bottom-right-radius:var(--stk--preset--border-radius--full, 9999px) !important;border-bottom-left-radius:var(--stk--preset--border-radius--none, 0px) !important;overflow:hidden !important;min-height:var(--stk--preset--block-height--none, 0px) !important;align-items:center !important;max-width:350px !important;min-width:auto !important;padding-top:var(--stk--preset--spacing--none, 0px) !important;padding-bottom:var(--stk--preset--spacing--none, 0px) !important;padding-left:60px !important;margin-top:var(--stk--preset--spacing--none, 0px) !important;margin-left:0px !important;display:flex !important;}.stk-095be29:before{background-color:var(--theme-palette-color-1, #164193) !important;}@media screen and (min-width:690px){.stk-095be29 {flex:var(--stk-flex-grow, 1) 1 calc(56% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-095be29-container stk--no-background stk--no-padding\"><div class=\"has-text-align-left stk--block-horizontal-flex stk-block-content stk-inner-blocks stk-095be29-inner-blocks\">\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-a3b5388\" data-block-id=\"a3b5388\"><style>.stk-a3b5388 {padding-top:var(--stk--preset--spacing--none, 0px) !important;padding-right:0px !important;padding-bottom:var(--stk--preset--spacing--none, 0px) !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-a3b5388-column\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-ec743fe\" data-v=\"4\" data-block-id=\"ec743fe\"><style>.stk-ec743fe {padding-left:var(--stk--preset--spacing--none, 0px) !important;margin-right:var(--stk--preset--spacing--none, 0px) !important;margin-left:var(--stk--preset--spacing--none, 0px) !important;}.stk-ec743fe-container{padding-left:var(--stk--preset--spacing--none, 0px) !important;}@media screen and (min-width:690px){.stk-ec743fe {flex:var(--stk-flex-grow, 1) 1 calc(66.667% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-ec743fe-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-ec743fe-inner-blocks\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-0108191\" id=\"strong-research-area-strong\" data-block-id=\"0108191\"><style>.stk-0108191 {margin-bottom:0px !important;}.stk-0108191 .stk-block-heading__text{color:var(--theme-palette-color-3, #a7a04d) !important;}<\/style><h6 class=\"stk-block-heading__text has-text-color\"><strong>Research area<\/strong><\/h6><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-0b4b126\" id=\"strong-neuroscience-strong\" data-block-id=\"0b4b126\"><style>.stk-0b4b126 {align-items:flex-start !important;padding-top:var(--stk--preset--spacing--none, 0px) !important;padding-bottom:var(--stk--preset--spacing--none, 0px) !important;margin-top:var(--stk--preset--spacing--none, 0px) !important;margin-bottom:var(--stk--preset--spacing--none, 0px) !important;margin-left:var(--stk--preset--spacing--none, 0px) !important;display:flex !important;}<\/style><h5 class=\"stk-block-heading__text\"><strong>Neuroscience<\/strong><\/h5><\/div>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-4110096\" data-v=\"4\" data-block-id=\"4110096\"><style>.stk-4110096 {align-self:center !important;padding-top:var(--stk--preset--spacing--none, 0px) !important;padding-right:var(--stk--preset--spacing--none, 0px) !important;padding-bottom:var(--stk--preset--spacing--none, 0px) !important;padding-left:var(--stk--preset--spacing--none, 0px) !important;margin-right:var(--stk--preset--spacing--none, 0px) !important;}.stk-4110096-inner-blocks{align-items:center !important;}@media screen and (min-width:690px){.stk-4110096 {flex:var(--stk-flex-grow, 1) 1 calc(33.333% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-4110096-container stk--no-background stk--no-padding\"><div class=\"stk--block-horizontal-flex stk--column-flex stk-block-content stk-inner-blocks stk-4110096-inner-blocks\">\n<div class=\"wp-block-stackable-image stk-block-image stk-block stk-5f46d71\" data-block-id=\"5f46d71\"><style>.stk-5f46d71 .stk-img-wrapper{width:100% !important;}<\/style><figure><span class=\"stk-img-wrapper stk-image--shape-stretch\"><img loading=\"lazy\" decoding=\"async\" class=\"stk-img wp-image-1066\" src=\"https:\/\/www.leloir.org.ar\/research\/wp-content\/uploads\/2026\/06\/neuro.png\" width=\"100\" height=\"100\"\/><\/span><\/figure><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-9284d94\" data-v=\"4\" data-block-id=\"9284d94\"><style>@media screen and (min-width:690px){.stk-9284d94 {flex:var(--stk-flex-grow, 1) 1 calc(44% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-9284d94-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-9284d94-inner-blocks\"><\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-spacer stk-block-spacer stk--no-padding stk-block stk-e4a0b9e\" data-block-id=\"e4a0b9e\"><style>.stk-e4a0b9e {height:30px !important;}<\/style><\/div>\n\n\n\n<div class=\"wp-block-greenshift-blocks-row alignwide gspb_row gspb_row-id-gsbp-22b4991 gspb_row--gutter-20\" id=\"gspb_row-id-gsbp-22b4991\">\n<div class=\"wp-block-greenshift-blocks-row-column gspb_row__col--9 gspb_col-id-gsbp-c9b3f6b\" id=\"gspb_col-id-gsbp-c9b3f6b\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-104d4ac\" id=\"neuronal-plasticity\" data-block-id=\"104d4ac\"><style>.stk-104d4ac {margin-bottom:40px !important;}.stk-104d4ac .stk-block-heading__text{color:var(--theme-palette-color-3, #a7a04d) !important;}<\/style><h2 class=\"stk-block-heading__text has-text-color\">NEURONAL PLASTICITY<\/h2><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-41b44af\" id=\"strong-research-strong\" data-block-id=\"41b44af\"><style>.stk-41b44af .stk-block-heading__text{color:var(--theme-palette-color-1, #164193) !important;}<\/style><h3 class=\"stk-block-heading__text has-text-color\"><strong>Research<\/strong><\/h3><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-bf578d0\" data-block-id=\"bf578d0\"><p class=\"stk-block-text__text\">The hippocampus is a brain region that harbors neural stem cells with the remarkable ability to generate new neurons throughout life. Our research focuses on unraveling the cellular and molecular mechanisms that govern the transformation of these stem cells into neurons, as well as the processes that regulate neuronal growth, integration into local circuits, and the selection of synaptic partners. We also explore key characteristics of adult-born neurons, examining how they contribute to learning and behavior. Our team has discovered that the aging brain retains the capacity to incorporate new neurons in a manner that is greatly enhanced when brain circuits are activated by specific stimuli. Currently, we are delving into the precise molecular pathways that control the growth, integration, and survival of new neurons in the adult, aging, and diseased brain. In addition, we analyze hippocampal biopsies from epileptic patients to assess the presence and functionality of immature neurons (potential adult-born cells) in humans, further investigating their properties and role in brain function.<\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-bef9c0d\" id=\"strong-skills-amp-tools-strong\" data-block-id=\"bef9c0d\"><style>.stk-bef9c0d .stk-block-heading__text{color:var(--theme-palette-color-1, #164193) !important;}<\/style><h3 class=\"stk-block-heading__text has-text-color\"><strong>Skills &amp; tools<\/strong><\/h3><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-6f973a4\" data-block-id=\"6f973a4\"><p class=\"stk-block-text__text\">We employ a multidisciplinary approach to tackle research questions from diverse perspectives. Genetic tagging techniques are combined with adeno-associated and retroviruses to selectively label or manipulate gene expression in specific neuronal populations, including adult-born granule cells, in the mouse brain. To investigate new neurons and their circuits, we utilize a variety of methods, such as examining fixed tissue sections for structural analysis, using acute brain slices for electrophysiological recordings, and dissociating tissue for FACS sorting and single-cell RNA sequencing. Our collaboration with bioinformaticians is integral to the analysis of single-cell RNA sequencing data. Additionally, we leverage optogenetic and chemogenetic tools to modulate the electrical activity of adult-born neurons, both in vivo and in vitro. Behavioral assays are routinely employed to evaluate learning and memory performance, providing insights into the functional roles of these neurons.<\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-8fb662c\" id=\"strong-collaboration-interests-strong\" data-block-id=\"8fb662c\"><style>.stk-8fb662c {margin-bottom:3px !important;}.stk-8fb662c .stk-block-heading__text{color:var(--theme-palette-color-1, #164193) !important;}<\/style><h3 class=\"stk-block-heading__text has-text-color\"><strong>Collaboration interests<\/strong><\/h3><\/div>\n\n\n\n<ul class=\"wp-block-list\">\n<li>In vivo electrophysiological and miniscope recordings<\/li>\n\n\n\n<li>In vivo two-photon imaging<\/li>\n\n\n\n<li>Dissection of cell signaling pathways<\/li>\n\n\n\n<li style=\"margin-bottom:24px\">In vivo gene manipulation technologies, including CRISPR\/Cas9<\/li>\n<\/ul>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-fb4e260\" id=\"strong-selected-publications-strong\" data-block-id=\"fb4e260\"><style>.stk-fb4e260 {margin-bottom:3px !important;}.stk-fb4e260 .stk-block-heading__text{color:var(--theme-palette-color-1, #164193) !important;}<\/style><h3 class=\"stk-block-heading__text has-text-color\"><strong>Selected publications<\/strong><\/h3><\/div>\n\n\n\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-6b0f0e9\" data-block-id=\"6b0f0e9\"><style>.stk-6b0f0e9 {padding-left:0px !important;margin-bottom:var(--stk--preset--spacing--none, 0px) !important;}.stk-6b0f0e9-column{--stk-column-gap:var(--stk--preset--spacing--20, 0.44rem) !important;justify-content:flex-start !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-6b0f0e9-column stk--flex\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-051e83d\" data-v=\"4\" data-block-id=\"051e83d\"><style>.stk-051e83d {min-height:var(--stk--preset--block-height--none, 0px) !important;max-width:1500px !important;min-width:auto !important;padding-left:var(--stk--preset--spacing--none, 0px) !important;margin-right:auto !important;margin-left:var(--stk--preset--spacing--none, 0px) !important;}@media screen and (min-width:690px){.stk-051e83d {flex:var(--stk-flex-grow, 1) 1 calc(82% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-051e83d-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-051e83d-inner-blocks\">\n<ul class=\"wp-block-list\">\n<li style=\"margin-left:0\">RASETTO, Natal\u00ed B., et al. Transcriptional dynamics orchestrating the development and integration of neurons born in the adult hippocampus. Science Advances, 2024, vol. 10, no 29, p. eadp6039.<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-3edd196\" data-v=\"4\" data-block-id=\"3edd196\"><style>@media screen and (min-width:690px){.stk-3edd196 {flex:var(--stk-flex-grow, 1) 1 calc(18% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}@media screen and (max-width:689px){.stk-3edd196-container{margin-left:30px !important;}.stk-3edd196 {align-self:center !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-3edd196-container stk--no-background stk--no-padding\"><div class=\"has-text-align-left-mobile stk-block-content stk-inner-blocks stk-3edd196-inner-blocks\">\n<div class=\"wp-block-stackable-button-group stk-block-button-group stk-block stk-12c0695\" data-block-id=\"12c0695\"><div class=\"stk-row stk-inner-blocks stk-block-content stk-button-group\">\n<div class=\"wp-block-stackable-icon-button stk-block-icon-button stk-block stk-5f4831a\" data-block-id=\"5f4831a\"><style>.stk-5f4831a .stk-button{background:var(--theme-palette-color-1, #164193) !important;}.stk-5f4831a .stk-button:hover{background:var(--theme-palette-color-2, #312a74) !important;opacity:1 !important;}<\/style><a class=\"stk-link stk-button stk--hover-effect-darken\" href=\"https:\/\/www.science.org\/doi\/abs\/10.1126\/sciadv.adp6039\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 640 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M579.8 267.7c56.5-56.5 56.5-148 0-204.5c-50-50-128.8-56.5-186.3-15.4l-1.6 1.1c-14.4 10.3-17.7 30.3-7.4 44.6s30.3 17.7 44.6 7.4l1.6-1.1c32.1-22.9 76-19.3 103.8 8.6c31.5 31.5 31.5 82.5 0 114L422.3 334.8c-31.5 31.5-82.5 31.5-114 0c-27.9-27.9-31.5-71.8-8.6-103.8l1.1-1.6c10.3-14.4 6.9-34.4-7.4-44.6s-34.4-6.9-44.6 7.4l-1.1 1.6C206.5 251.2 213 330 263 380c56.5 56.5 148 56.5 204.5 0L579.8 267.7zM60.2 244.3c-56.5 56.5-56.5 148 0 204.5c50 50 128.8 56.5 186.3 15.4l1.6-1.1c14.4-10.3 17.7-30.3 7.4-44.6s-30.3-17.7-44.6-7.4l-1.6 1.1c-32.1 22.9-76 19.3-103.8-8.6C74 372 74 321 105.5 289.5L217.7 177.2c31.5-31.5 82.5-31.5 114 0c27.9 27.9 31.5 71.8 8.6 103.9l-1.1 1.6c-10.3 14.4-6.9 34.4 7.4 44.6s34.4 6.9 44.6-7.4l1.1-1.6C433.5 260.8 427 182 377 132c-56.5-56.5-148-56.5-204.5 0L60.2 244.3z\"\/><\/svg><\/div><\/span><\/a><\/div>\n<\/div><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-divider alignfull stk-block-divider stk--hide-desktop has-text-align-center stk-block stk-4d9b612\" data-block-id=\"4d9b612\"><style>.stk-4d9b612 hr.stk-block-divider__hr{background:#abb8c3 !important;}@media screen and (max-width:689px){.stk-4d9b612 {align-items:center !important;margin-bottom:0px !important;display:flex !important;}}<\/style><hr class=\"stk-block-divider__hr\"\/><\/div>\n\n\n\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-bf15457\" data-block-id=\"bf15457\"><style>.stk-bf15457 {padding-left:0px !important;margin-bottom:var(--stk--preset--spacing--none, 0px) !important;}.stk-bf15457-column{--stk-column-gap:var(--stk--preset--spacing--20, 0.44rem) !important;justify-content:flex-start !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-bf15457-column stk--flex\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-82616a0\" data-v=\"4\" data-block-id=\"82616a0\"><style>.stk-82616a0 {min-height:var(--stk--preset--block-height--none, 0px) !important;max-width:1500px !important;min-width:auto !important;padding-left:var(--stk--preset--spacing--none, 0px) !important;margin-right:auto !important;margin-left:var(--stk--preset--spacing--none, 0px) !important;}@media screen and (min-width:690px){.stk-82616a0 {flex:var(--stk-flex-grow, 1) 1 calc(82% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-82616a0-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-82616a0-inner-blocks\">\n<ul class=\"wp-block-list\">\n<li style=\"margin-left:0\">TRINCHERO, Mariela F., et al. High plasticity of new granule cells in the aging hippocampus. Cell reports, 2017, vol. 21, no 5, p. 1129-1139.<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-8f43baf\" data-v=\"4\" data-block-id=\"8f43baf\"><style>@media screen and (min-width:690px){.stk-8f43baf {flex:var(--stk-flex-grow, 1) 1 calc(18% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}@media screen and (max-width:689px){.stk-8f43baf-container{margin-left:30px !important;}.stk-8f43baf {align-self:center !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-8f43baf-container stk--no-background stk--no-padding\"><div class=\"has-text-align-left-mobile stk-block-content stk-inner-blocks stk-8f43baf-inner-blocks\">\n<div class=\"wp-block-stackable-button-group stk-block-button-group stk-block stk-361a94b\" data-block-id=\"361a94b\"><div class=\"stk-row stk-inner-blocks stk-block-content stk-button-group\">\n<div class=\"wp-block-stackable-icon-button stk-block-icon-button stk-block stk-b97f828\" data-block-id=\"b97f828\"><style>.stk-b97f828 .stk-button{background:var(--theme-palette-color-1, #164193) !important;}.stk-b97f828 .stk-button:hover{background:var(--theme-palette-color-2, #312a74) !important;opacity:1 !important;}<\/style><a class=\"stk-link stk-button stk--hover-effect-darken\" href=\"https:\/\/www.cell.com\/cell-reports\/fulltext\/S2211-1247(17)31354-2\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 640 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M579.8 267.7c56.5-56.5 56.5-148 0-204.5c-50-50-128.8-56.5-186.3-15.4l-1.6 1.1c-14.4 10.3-17.7 30.3-7.4 44.6s30.3 17.7 44.6 7.4l1.6-1.1c32.1-22.9 76-19.3 103.8 8.6c31.5 31.5 31.5 82.5 0 114L422.3 334.8c-31.5 31.5-82.5 31.5-114 0c-27.9-27.9-31.5-71.8-8.6-103.8l1.1-1.6c10.3-14.4 6.9-34.4-7.4-44.6s-34.4-6.9-44.6 7.4l-1.1 1.6C206.5 251.2 213 330 263 380c56.5 56.5 148 56.5 204.5 0L579.8 267.7zM60.2 244.3c-56.5 56.5-56.5 148 0 204.5c50 50 128.8 56.5 186.3 15.4l1.6-1.1c14.4-10.3 17.7-30.3 7.4-44.6s-30.3-17.7-44.6-7.4l-1.6 1.1c-32.1 22.9-76 19.3-103.8-8.6C74 372 74 321 105.5 289.5L217.7 177.2c31.5-31.5 82.5-31.5 114 0c27.9 27.9 31.5 71.8 8.6 103.9l-1.1 1.6c-10.3 14.4-6.9 34.4 7.4 44.6s34.4 6.9 44.6-7.4l1.1-1.6C433.5 260.8 427 182 377 132c-56.5-56.5-148-56.5-204.5 0L60.2 244.3z\"\/><\/svg><\/div><\/span><\/a><\/div>\n<\/div><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-divider alignfull stk-block-divider stk--hide-desktop has-text-align-center stk-block stk-22c4795\" data-block-id=\"22c4795\"><style>.stk-22c4795 hr.stk-block-divider__hr{background:#abb8c3 !important;}@media screen and (max-width:689px){.stk-22c4795 {align-items:center !important;margin-bottom:0px !important;display:flex !important;}}<\/style><hr class=\"stk-block-divider__hr\"\/><\/div>\n\n\n\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-a2d56a6\" data-block-id=\"a2d56a6\"><style>.stk-a2d56a6 {padding-left:0px !important;margin-bottom:var(--stk--preset--spacing--none, 0px) !important;}.stk-a2d56a6-column{--stk-column-gap:var(--stk--preset--spacing--20, 0.44rem) !important;justify-content:flex-start !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-a2d56a6-column stk--flex\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-4b33d14\" data-v=\"4\" data-block-id=\"4b33d14\"><style>.stk-4b33d14 {min-height:var(--stk--preset--block-height--none, 0px) !important;max-width:1500px !important;min-width:auto !important;padding-left:var(--stk--preset--spacing--none, 0px) !important;margin-right:auto !important;margin-left:var(--stk--preset--spacing--none, 0px) !important;}@media screen and (min-width:690px){.stk-4b33d14 {flex:var(--stk-flex-grow, 1) 1 calc(82% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-4b33d14-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-4b33d14-inner-blocks\">\n<ul class=\"wp-block-list\">\n<li style=\"margin-left:0\">ALVAREZ, Diego D., et al. A disynaptic feedback network activated by experience promotes the integration of new granule cells. Science, 2016, vol. 354, no 6311, p. 459-465.<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-84af16c\" data-v=\"4\" data-block-id=\"84af16c\"><style>@media screen and (min-width:690px){.stk-84af16c {flex:var(--stk-flex-grow, 1) 1 calc(18% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}@media screen and (max-width:689px){.stk-84af16c-container{margin-left:30px !important;}.stk-84af16c {align-self:center !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-84af16c-container stk--no-background stk--no-padding\"><div class=\"has-text-align-left-mobile stk-block-content stk-inner-blocks stk-84af16c-inner-blocks\">\n<div class=\"wp-block-stackable-button-group stk-block-button-group stk-block stk-ffe44e6\" data-block-id=\"ffe44e6\"><div class=\"stk-row stk-inner-blocks stk-block-content stk-button-group\">\n<div class=\"wp-block-stackable-icon-button stk-block-icon-button stk-block stk-4553922\" data-block-id=\"4553922\"><style>.stk-4553922 .stk-button{background:var(--theme-palette-color-1, #164193) !important;}.stk-4553922 .stk-button:hover{background:var(--theme-palette-color-2, #312a74) !important;opacity:1 !important;}<\/style><a class=\"stk-link stk-button stk--hover-effect-darken\" href=\"https:\/\/www.science.org\/doi\/abs\/10.1126\/science.aaf2156\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 640 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M579.8 267.7c56.5-56.5 56.5-148 0-204.5c-50-50-128.8-56.5-186.3-15.4l-1.6 1.1c-14.4 10.3-17.7 30.3-7.4 44.6s30.3 17.7 44.6 7.4l1.6-1.1c32.1-22.9 76-19.3 103.8 8.6c31.5 31.5 31.5 82.5 0 114L422.3 334.8c-31.5 31.5-82.5 31.5-114 0c-27.9-27.9-31.5-71.8-8.6-103.8l1.1-1.6c10.3-14.4 6.9-34.4-7.4-44.6s-34.4-6.9-44.6 7.4l-1.1 1.6C206.5 251.2 213 330 263 380c56.5 56.5 148 56.5 204.5 0L579.8 267.7zM60.2 244.3c-56.5 56.5-56.5 148 0 204.5c50 50 128.8 56.5 186.3 15.4l1.6-1.1c14.4-10.3 17.7-30.3 7.4-44.6s-30.3-17.7-44.6-7.4l-1.6 1.1c-32.1 22.9-76 19.3-103.8-8.6C74 372 74 321 105.5 289.5L217.7 177.2c31.5-31.5 82.5-31.5 114 0c27.9 27.9 31.5 71.8 8.6 103.9l-1.1 1.6c-10.3 14.4-6.9 34.4 7.4 44.6s34.4 6.9 44.6-7.4l1.1-1.6C433.5 260.8 427 182 377 132c-56.5-56.5-148-56.5-204.5 0L60.2 244.3z\"\/><\/svg><\/div><\/span><\/a><\/div>\n<\/div><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-divider alignfull stk-block-divider stk--hide-desktop has-text-align-center stk-block stk-00e5827\" data-block-id=\"00e5827\"><style>.stk-00e5827 hr.stk-block-divider__hr{background:#abb8c3 !important;}@media screen and (max-width:689px){.stk-00e5827 {align-items:center !important;margin-bottom:0px !important;display:flex !important;}}<\/style><hr class=\"stk-block-divider__hr\"\/><\/div>\n\n\n\n<div class=\"wp-block-stackable-spacer stk-block-spacer stk--no-padding stk-block stk-a00a56c\" data-block-id=\"a00a56c\"><style>.stk-a00a56c {height:30px !important;}<\/style><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-greenshift-blocks-row-column gspb_row__col--3 gspb_col-id-gsbp-f78c24f\" id=\"gspb_col-id-gsbp-f78c24f\">\n<div class=\"wp-block-stackable-image stk-block-image stk-block stk-f475dab\" data-block-id=\"f475dab\"><style>.stk-f475dab .stk-img-wrapper{width:80% !important;}<\/style><figure><span class=\"stk-img-wrapper stk-image--shape-stretch\"><img loading=\"lazy\" decoding=\"async\" class=\"stk-img wp-image-1160\" src=\"https:\/\/www.leloir.org.ar\/research\/wp-content\/uploads\/2026\/06\/Fil__Schinder.png\" width=\"400\" height=\"400\" srcset=\"https:\/\/www.leloir.org.ar\/research\/wp-content\/uploads\/2026\/06\/Fil__Schinder.png 400w, https:\/\/www.leloir.org.ar\/research\/wp-content\/uploads\/2026\/06\/Fil__Schinder-300x300.png 300w, https:\/\/www.leloir.org.ar\/research\/wp-content\/uploads\/2026\/06\/Fil__Schinder-150x150.png 150w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/span><\/figure><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-b236174\" data-block-id=\"b236174\"><style>.stk-b236174 {margin-bottom:0px !important;}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #ffffff;\" class=\"stk-highlight\">Principal investigator<\/span><\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-c6eea5f\" id=\"alejandro-f-schinder-ph-d\" data-block-id=\"c6eea5f\"><style>.stk-c6eea5f .stk-block-heading__text{line-height:1.2em !important;}<\/style><h4 class=\"stk-block-heading__text\">Alejandro F. Schinder, PhD<\/h4><\/div>\n\n\n\n<div class=\"wp-block-stackable-icon-label stk-block-icon-label stk-block stk-920abd0\" data-block-id=\"920abd0\"><style>.stk-920abd0 .stk-inner-blocks{gap:10px !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content\">\n<div class=\"wp-block-stackable-icon stk-block-icon has-text-align-left stk-block stk-dd29c01\" data-block-id=\"dd29c01\"><style>.stk-dd29c01 .stk--svg-wrapper .stk--inner-svg svg:last-child{height:22px !important;width:22px !important;}.stk-dd29c01 .stk--svg-wrapper .stk--inner-svg svg:last-child, .stk-dd29c01 .stk--svg-wrapper .stk--inner-svg svg:last-child :is(g, path, rect, polygon, ellipse){fill:var(--theme-palette-color-5, #35b6b4) !important;}<\/style><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg style=\"height:0;width:0\"><defs><linearGradient id=\"linear-gradient-dd29c01\" x1=\"0\" x2=\"100%\" y1=\"0\" y2=\"0\"><stop offset=\"0%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-dd-29-c-01-color-1)\"><\/stop><stop offset=\"100%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-dd-29-c-01-color-2)\"><\/stop><\/linearGradient><\/defs><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M64 112c-8.8 0-16 7.2-16 16v22.1L220.5 291.7c20.7 17 50.4 17 71.1 0L464 150.1V128c0-8.8-7.2-16-16-16H64zM48 212.2V384c0 8.8 7.2 16 16 16H448c8.8 0 16-7.2 16-16V212.2L322 328.8c-38.4 31.5-93.7 31.5-132 0L48 212.2zM0 128C0 92.7 28.7 64 64 64H448c35.3 0 64 28.7 64 64V384c0 35.3-28.7 64-64 64H64c-35.3 0-64-28.7-64-64V128z\"\/><\/svg><\/div><\/span><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-7b80074\" id=\"a-href-mailto-aschinder-leloir-org-ar-aschinder-leloir-org-ar-a\" data-block-id=\"7b80074\"><style>.stk-7b80074 .stk-block-heading__text{font-size:1.2rem !important;color:var(--theme-palette-color-5, #35b6b4) !important;}@media screen and (max-width:999px){.stk-7b80074 .stk-block-heading__text{font-size:1.2rem !important;}}<\/style><p class=\"stk-block-heading__text has-text-color\"><a href=\"mailto:aschinder@leloir.org.ar\">aschinder@leloir.org.ar<\/a><\/p><\/div>\n<\/div><\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-a0e1fa3\" data-block-id=\"a0e1fa3\"><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-a0e1fa3-column\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-8ec3b2b\" data-v=\"4\" data-block-id=\"8ec3b2b\"><style>@media screen and (min-width:690px){.stk-8ec3b2b {flex:var(--stk-flex-grow, 1) 1 calc(20% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-8ec3b2b-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-8ec3b2b-inner-blocks\">\n<div class=\"wp-block-stackable-icon stk-block-icon stk-block stk-cacdf15\" data-block-id=\"cacdf15\"><style>.stk-cacdf15 .stk--svg-wrapper .stk--inner-svg svg:last-child{height:18px !important;width:18px !important;}.stk-cacdf15 .stk--svg-wrapper .stk--inner-svg svg:last-child, .stk-cacdf15 .stk--svg-wrapper .stk--inner-svg svg:last-child :is(g, path, rect, polygon, ellipse){fill:var(--theme-palette-color-3, #a7a04d) !important;}<\/style><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg style=\"height:0;width:0\"><defs><linearGradient id=\"linear-gradient-cacdf15\" x1=\"0\" x2=\"100%\" y1=\"0\" y2=\"0\"><stop offset=\"0%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-cacdf-15-color-1)\"><\/stop><stop offset=\"100%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-cacdf-15-color-2)\"><\/stop><\/linearGradient><\/defs><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M336 352c97.2 0 176-78.8 176-176S433.2 0 336 0S160 78.8 160 176c0 18.7 2.9 36.8 8.3 53.7L7 391c-4.5 4.5-7 10.6-7 17v80c0 13.3 10.7 24 24 24h80c13.3 0 24-10.7 24-24V448h40c13.3 0 24-10.7 24-24V384h40c6.4 0 12.5-2.5 17-7l33.3-33.3c16.9 5.4 35 8.3 53.7 8.3zM376 96a40 40 0 1 1 0 80 40 40 0 1 1 0-80z\"\/><\/svg><\/div><\/span><\/div>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-0ccde29\" data-v=\"4\" data-block-id=\"0ccde29\"><style>@media screen and (min-width:690px){.stk-0ccde29 {flex:var(--stk-flex-grow, 1) 1 calc(80% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-0ccde29-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-0ccde29-inner-blocks\">\n<ul style=\"padding-right:0;padding-left:0\" class=\"wp-block-list\">\n<li class=\"has-palette-color-3-color has-text-color has-link-color wp-elements-8af141783d391bca85af45ef9fa8ae17\" style=\"line-height:1.3\">adult neurogenesis<br><\/li>\n\n\n\n<li class=\"has-palette-color-3-color has-text-color has-link-color wp-elements-cf73a2bb2d020d732110281cca0fa7a0\" style=\"line-height:1.3\">hippocampal plasticity<br><\/li>\n\n\n\n<li class=\"has-palette-color-3-color has-text-color has-link-color wp-elements-0224d2de3a035bca303620428861a35b\" style=\"line-height:1.3\">stem cell integration<br><\/li>\n\n\n\n<li class=\"has-palette-color-3-color has-text-color has-link-color wp-elements-6f73e92b2ee054f1e3b4082d46d0b207\" style=\"line-height:1.3\">learning and memory<br><\/li>\n\n\n\n<li class=\"has-palette-color-3-color has-text-color has-link-color wp-elements-66a978a42dc81b8f20801811dbfe2a4f\" style=\"line-height:1.3\">aging brain<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n<\/div><\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Research area Neuroscience<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_gspb_post_css":"#gspb_row-id-gsbp-22b4991{justify-content:space-between;margin-top:0;display:flex;flex-wrap:wrap;margin-bottom:0;margin-left:0;padding-left:0}#gspb_row-id-gsbp-22b4991>.gspb_row__content{display:flex;justify-content:space-between;margin:0 auto;width:100%;flex-wrap:wrap}div[id^=gspb_col-id]{box-sizing:border-box;position:relative;padding:var(--gs-row-column-padding, 15px min(3vw, 20px))}#gspb_col-id-gsbp-c9b3f6b.gspb_row__col--9{width:calc(75% - 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