{"id":1350,"date":"2026-06-29T17:04:49","date_gmt":"2026-06-29T20:04:49","guid":{"rendered":"https:\/\/www.leloir.org.ar\/research\/?page_id=1350"},"modified":"2026-08-06T15:48:35","modified_gmt":"2026-08-06T18:48:35","slug":"developmental-neurogenetics","status":"publish","type":"page","link":"https:\/\/www.leloir.org.ar\/research\/developmental-neurogenetics\/","title":{"rendered":"developmental neurogenetics"},"content":{"rendered":"\n<div class=\"wp-block-stackable-spacer stk-block-spacer stk--no-padding stk-block stk-5bf724e\" data-block-id=\"5bf724e\"><style>.stk-5bf724e {height:20px !important;}<\/style><\/div>\n\n\n\n<div class=\"wp-block-greenshift-blocks-row alignfull gspb_row gspb_row-id-gsbp-5a0b21f\" id=\"gspb_row-id-gsbp-5a0b21f\"><div class=\"gspb_row__content\"> \n<div class=\"wp-block-greenshift-blocks-row-column gspb_row__col--4 gspb_row__col--xs-12 gspb_col-id-gsbp-184ece8\" id=\"gspb_col-id-gsbp-184ece8\">\n<h6 id=\"gspb_heading-id-gsbp-6cea568\" class=\"gspb_heading gspb_heading-id-gsbp-6cea568 \"><strong>Research area<\/strong><\/h6>\n\n\n\n<h5 id=\"gspb_heading-id-gsbp-5187666\" class=\"gspb_heading gspb_heading-id-gsbp-5187666 \"><strong>Cell and developmental biology<\/strong><br><strong><strong><strong>Neuroscience<\/strong><\/strong><\/strong><\/h5>\n<\/div>\n\n\n\n<div class=\"wp-block-greenshift-blocks-row-column gspb_row__col--8 gspb_row__col--xs-12 gspb_col-id-gsbp-0b7cdeb\" id=\"gspb_col-id-gsbp-0b7cdeb\">\n<div class=\"wp-block-greenshift-blocks-container gspb_container gspb_container-gsbp-3fa2f65\" id=\"gspb_container-id-gsbp-3fa2f65\">\n<div class=\"wp-block-greenshift-blocks-iconbox gspb_iconBox gspb_iconBox-id-gsbp-c5db4cd\" id=\"gspb_iconBox-id-gsbp-c5db4cd\"><div class=\"gspb_iconBox__wrapper\" style=\"display:inline-flex\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" style=\"width:5rem;height:5rem;margin:10px\" id=\"a\" dataname=\"Capa 1\" viewBox=\"0 0 75 75\">  <path 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d=\"M45.68,26.84c.29,0,.58-.14.76-.4l3.26-4.66c.3-.42.19-1-.23-1.3-.42-.3-1.01-.19-1.3.23l-3.26,4.66c-.3.42-.19,1,.23,1.3.16.11.35.17.53.17\" fill=\"#a7a04d\"><\/path>\n  <path d=\"M23.89,36.22c-.45-.25-1.02-.09-1.27.36l-3.42,6.14c-.25.45-.09,1.02.36,1.27.14.08.3.12.45.12.33,0,.64-.17.82-.48l3.42-6.14c.25-.45.09-1.02-.36-1.27\" fill=\"#a7a04d\"><\/path>\n  <path d=\"M54.19,29.98l-6.52-1.09c-.5-.08-.99.26-1.07.77-.08.51.26.99.77,1.07l6.53,1.09c.05,0,.1.01.15.01.45,0,.84-.32.92-.78.08-.51-.26-.99-.77-1.07\" fill=\"#a7a04d\"><\/path>\n  <path d=\"M32.73,51.85l-6.37-1.32c-.51-.1-1,.22-1.1.72-.1.51.22,1,.72,1.1l6.37,1.32c.06.01.13.02.19.02.43,0,.82-.3.91-.74.1-.5-.22-1-.72-1.1\" fill=\"#a7a04d\"><\/path>\n  <path d=\"M56.91,35.42c-.08-.51-.56-.85-1.07-.77-.51.08-.85.56-.77,1.07l1.01,6.21c.07.46.47.78.92.78.05,0,.1,0,.15-.01.51-.08.85-.56.77-1.07l-1.01-6.21Z\" fill=\"#a7a04d\"><\/path>\n  <path d=\"M22.9,25.12c.11,0,.22-.02.33-.06l6.68-2.49c.48-.18.73-.72.55-1.2-.18-.48-.72-.73-1.2-.55l-6.68,2.49c-.48.18-.73.72-.55,1.2.14.38.5.61.87.61\" fill=\"#a7a04d\"><\/path>\n  <path d=\"M31.81,27.87l6.06,3.11c.14.07.28.1.42.1.34,0,.67-.18.83-.51.23-.46.05-1.02-.4-1.25l-6.06-3.11c-.46-.23-1.02-.06-1.25.4-.24.46-.05,1.02.4,1.25\" fill=\"#a7a04d\"><\/path>\n  <path d=\"M28.9,46.07c-.47-.47-.73-1.11-.73-1.78s.26-1.31.73-1.78l6.84-6.84c.47-.47,1.11-.74,1.78-.74s1.31.26,1.78.74c.48.48.74,1.11.74,1.78s-.26,1.31-.74,1.78l-6.84,6.83c-.95.95-2.61.95-3.56,0M34.36,34.3l-6.83,6.84c-.84.84-1.31,1.96-1.31,3.15s.46,2.31,1.31,3.15c.84.84,1.96,1.31,3.15,1.31s2.31-.46,3.15-1.31l6.83-6.83c.84-.84,1.31-1.96,1.31-3.15s-.46-2.31-1.31-3.15c-1.68-1.68-4.62-1.68-6.3,0\" fill=\"#a7a04d\"><\/path>\n<\/svg><\/div><\/div>\n<\/div>\n<\/div>\n <\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-spacer stk-block-spacer stk--no-padding stk-block stk-e4a0b9e\" data-block-id=\"e4a0b9e\"><style>.stk-e4a0b9e {height:30px !important;}<\/style><\/div>\n\n\n\n<div class=\"wp-block-greenshift-blocks-row alignwide gspb_row gspb_row-id-gsbp-22b4991 gspb_row--gutter-20\" id=\"gspb_row-id-gsbp-22b4991\">\n<div class=\"wp-block-greenshift-blocks-row-column gspb_row__col--9 gspb_col-id-gsbp-c9b3f6b\" id=\"gspb_col-id-gsbp-c9b3f6b\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-104d4ac\" id=\"developmental-neurogenetics\" data-block-id=\"104d4ac\"><style>.stk-104d4ac {margin-bottom:40px !important;}.stk-104d4ac .stk-block-heading__text{color:var(--theme-palette-color-3, #a7a04d) !important;}<\/style><h2 class=\"stk-block-heading__text has-text-color\">DEVELOPMENTAL NEUROGENETICS<\/h2><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-41b44af\" id=\"strong-research-strong\" data-block-id=\"41b44af\"><style>.stk-41b44af .stk-block-heading__text{color:var(--theme-palette-color-1, #164193) !important;}<\/style><h3 class=\"stk-block-heading__text has-text-color\"><strong>Research<\/strong><\/h3><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-bf578d0\" data-block-id=\"bf578d0\"><p class=\"stk-block-text__text\">The development of a functional nervous system critically depends on the production of a diverse array of neuronal and glial cell types at the correct locations, at the right time and in appropriate numbers. This cellular diversity arises through a coordinated series of steps that regulate neural progenitor differentiation, identity specification, axonal outgrowth and synapse formation. We have employed developmental genetics to characterize and manipulate specific neuronal populations in the spinal cord that serve dedicated roles in sensory and motor circuits. Our recent work has delineated the transcriptional program that drives late neurogenesis in the spinal cord and specifies sensory cerebrospinal fluid-contacting neurons during embryonic stages previously thought to be exclusively gliogenic. We have also investigated the ontogenetic mechanisms underlying astrocyte heterogeneity and provided strong evidence for the existence of region-specific astrocytic subtypes whose allocation depends on progenitor identity.<\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-bef9c0d\" id=\"strong-skills-amp-tools-strong\" data-block-id=\"bef9c0d\"><style>.stk-bef9c0d .stk-block-heading__text{color:var(--theme-palette-color-1, #164193) !important;}<\/style><h3 class=\"stk-block-heading__text has-text-color\"><strong>Skills &amp; tools<\/strong><\/h3><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-6f973a4\" data-block-id=\"6f973a4\"><p class=\"stk-block-text__text\">Our lab has developed strong expertise in mouse molecular genetics to manipulate gene expression in a temporally and spatially controlled manner, and to perform in vivo cell fate mapping and clonal lineage tracing. We use in ovo electroporation in the chick and in utero electroporation in the mouse embryo to assess candidate gene functions. To map neural circuits and connectivity, we take advantage of axonal and synaptic terminal reporter labeling as well as viral trans-synaptic tracing techniques. These approaches are combined with confocal microscopy, immunohistochemistry and high-resolution imaging. Functional studies are complemented by phenotypic analysis of mutants and expression profiling of developing neural tissues.<\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-8fb662c\" id=\"strong-collaboration-interests-strong\" data-block-id=\"8fb662c\"><style>.stk-8fb662c {margin-bottom:3px !important;}.stk-8fb662c .stk-block-heading__text{color:var(--theme-palette-color-1, #164193) !important;}<\/style><h3 class=\"stk-block-heading__text has-text-color\"><strong>Collaboration interests<\/strong><\/h3><\/div>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Single cell transcriptomics and bioinformatics<\/li>\n\n\n\n<li>Physiology of motor and respiratory circuits<\/li>\n\n\n\n<li style=\"margin-bottom:24px\">Live imaging for cell migration<\/li>\n<\/ul>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-fb4e260\" id=\"strong-selected-publications-strong\" data-block-id=\"fb4e260\"><style>.stk-fb4e260 {margin-bottom:3px !important;}.stk-fb4e260 .stk-block-heading__text{color:var(--theme-palette-color-1, #164193) !important;}<\/style><h3 class=\"stk-block-heading__text has-text-color\"><strong>Selected publications<\/strong><\/h3><\/div>\n\n\n\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-6b0f0e9\" data-block-id=\"6b0f0e9\"><style>.stk-6b0f0e9 {padding-left:0px !important;margin-bottom:var(--stk--preset--spacing--none, 0px) !important;}.stk-6b0f0e9-column{--stk-column-gap:var(--stk--preset--spacing--20, 0.44rem) !important;justify-content:flex-start !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-6b0f0e9-column stk--flex\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-051e83d\" data-v=\"4\" data-block-id=\"051e83d\"><style>.stk-051e83d {min-height:var(--stk--preset--block-height--none, 0px) !important;max-width:1500px !important;min-width:auto !important;padding-left:var(--stk--preset--spacing--none, 0px) !important;margin-right:auto !important;margin-left:var(--stk--preset--spacing--none, 0px) !important;}@media screen and (min-width:690px){.stk-051e83d {flex:var(--stk-flex-grow, 1) 1 calc(82% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-051e83d-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-051e83d-inner-blocks\">\n<ul class=\"wp-block-list\">\n<li style=\"margin-left:0\">SARTORETTI, Maria Micaela; CAMPETELLA, Carla A.; LANUZA, Guillermo M. Dbx1 controls the development of astrocytes of the intermediate spinal cord by modulating Notch signaling. Development, 2022, vol. 149, no 15, p. dev200750.<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-3edd196\" data-v=\"4\" data-block-id=\"3edd196\"><style>@media screen and (min-width:690px){.stk-3edd196 {flex:var(--stk-flex-grow, 1) 1 calc(18% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}@media screen and (max-width:689px){.stk-3edd196-container{margin-left:30px !important;}.stk-3edd196 {align-self:center !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-3edd196-container stk--no-background stk--no-padding\"><div class=\"has-text-align-left-mobile stk-block-content stk-inner-blocks stk-3edd196-inner-blocks\">\n<div class=\"wp-block-stackable-button-group stk-block-button-group stk-block stk-12c0695\" data-block-id=\"12c0695\"><div class=\"stk-row stk-inner-blocks stk-block-content stk-button-group\">\n<div class=\"wp-block-stackable-icon-button stk-block-icon-button stk-block stk-5f4831a\" data-block-id=\"5f4831a\"><style>.stk-5f4831a .stk-button{background:var(--theme-palette-color-1, #164193) !important;}.stk-5f4831a .stk-button:hover{background:var(--theme-palette-color-2, #312a74) !important;opacity:1 !important;}<\/style><a class=\"stk-link stk-button stk--hover-effect-darken\" href=\"https:\/\/journals.biologists.com\/dev\/article-abstract\/149\/15\/dev200750\/276178\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 640 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M579.8 267.7c56.5-56.5 56.5-148 0-204.5c-50-50-128.8-56.5-186.3-15.4l-1.6 1.1c-14.4 10.3-17.7 30.3-7.4 44.6s30.3 17.7 44.6 7.4l1.6-1.1c32.1-22.9 76-19.3 103.8 8.6c31.5 31.5 31.5 82.5 0 114L422.3 334.8c-31.5 31.5-82.5 31.5-114 0c-27.9-27.9-31.5-71.8-8.6-103.8l1.1-1.6c10.3-14.4 6.9-34.4-7.4-44.6s-34.4-6.9-44.6 7.4l-1.1 1.6C206.5 251.2 213 330 263 380c56.5 56.5 148 56.5 204.5 0L579.8 267.7zM60.2 244.3c-56.5 56.5-56.5 148 0 204.5c50 50 128.8 56.5 186.3 15.4l1.6-1.1c14.4-10.3 17.7-30.3 7.4-44.6s-30.3-17.7-44.6-7.4l-1.6 1.1c-32.1 22.9-76 19.3-103.8-8.6C74 372 74 321 105.5 289.5L217.7 177.2c31.5-31.5 82.5-31.5 114 0c27.9 27.9 31.5 71.8 8.6 103.9l-1.1 1.6c-10.3 14.4-6.9 34.4 7.4 44.6s34.4 6.9 44.6-7.4l1.1-1.6C433.5 260.8 427 182 377 132c-56.5-56.5-148-56.5-204.5 0L60.2 244.3z\"\/><\/svg><\/div><\/span><\/a><\/div>\n<\/div><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-divider alignfull stk-block-divider stk--hide-desktop has-text-align-center stk-block stk-397def0\" data-block-id=\"397def0\"><style>.stk-397def0 hr.stk-block-divider__hr{background:#abb8c3 !important;}@media screen and (max-width:689px){.stk-397def0 {align-items:center !important;margin-bottom:0px !important;display:flex !important;}}<\/style><hr class=\"stk-block-divider__hr\"\/><\/div>\n\n\n\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-bf15457\" data-block-id=\"bf15457\"><style>.stk-bf15457 {padding-left:0px !important;margin-bottom:var(--stk--preset--spacing--none, 0px) !important;}.stk-bf15457-column{--stk-column-gap:var(--stk--preset--spacing--20, 0.44rem) !important;justify-content:flex-start !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-bf15457-column stk--flex\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-82616a0\" data-v=\"4\" data-block-id=\"82616a0\"><style>.stk-82616a0 {min-height:var(--stk--preset--block-height--none, 0px) !important;max-width:1500px !important;min-width:auto !important;padding-left:var(--stk--preset--spacing--none, 0px) !important;margin-right:auto !important;margin-left:var(--stk--preset--spacing--none, 0px) !important;}@media screen and (min-width:690px){.stk-82616a0 {flex:var(--stk-flex-grow, 1) 1 calc(82% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-82616a0-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-82616a0-inner-blocks\">\n<ul class=\"wp-block-list\">\n<li style=\"margin-left:0\">DI BELLA, Daniela J., et al. Ascl1 balances neuronal versus ependymal fate in the spinal cord central canal. Cell reports, 2019, vol. 28, no 9, p. 2264-2274. e3.<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-8f43baf\" data-v=\"4\" data-block-id=\"8f43baf\"><style>@media screen and (min-width:690px){.stk-8f43baf {flex:var(--stk-flex-grow, 1) 1 calc(18% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}@media screen and (max-width:689px){.stk-8f43baf-container{margin-left:30px !important;}.stk-8f43baf {align-self:center !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-8f43baf-container stk--no-background stk--no-padding\"><div class=\"has-text-align-left-mobile stk-block-content stk-inner-blocks stk-8f43baf-inner-blocks\">\n<div class=\"wp-block-stackable-button-group stk-block-button-group stk-block stk-361a94b\" data-block-id=\"361a94b\"><div class=\"stk-row stk-inner-blocks stk-block-content stk-button-group\">\n<div class=\"wp-block-stackable-icon-button stk-block-icon-button stk-block stk-b97f828\" data-block-id=\"b97f828\"><style>.stk-b97f828 .stk-button{background:var(--theme-palette-color-1, #164193) !important;}.stk-b97f828 .stk-button:hover{background:var(--theme-palette-color-2, #312a74) !important;opacity:1 !important;}<\/style><a class=\"stk-link stk-button stk--hover-effect-darken\" href=\"https:\/\/www.cell.com\/cell-reports\/fulltext\/S2211-1247(19)31003-4\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 640 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M579.8 267.7c56.5-56.5 56.5-148 0-204.5c-50-50-128.8-56.5-186.3-15.4l-1.6 1.1c-14.4 10.3-17.7 30.3-7.4 44.6s30.3 17.7 44.6 7.4l1.6-1.1c32.1-22.9 76-19.3 103.8 8.6c31.5 31.5 31.5 82.5 0 114L422.3 334.8c-31.5 31.5-82.5 31.5-114 0c-27.9-27.9-31.5-71.8-8.6-103.8l1.1-1.6c10.3-14.4 6.9-34.4-7.4-44.6s-34.4-6.9-44.6 7.4l-1.1 1.6C206.5 251.2 213 330 263 380c56.5 56.5 148 56.5 204.5 0L579.8 267.7zM60.2 244.3c-56.5 56.5-56.5 148 0 204.5c50 50 128.8 56.5 186.3 15.4l1.6-1.1c14.4-10.3 17.7-30.3 7.4-44.6s-30.3-17.7-44.6-7.4l-1.6 1.1c-32.1 22.9-76 19.3-103.8-8.6C74 372 74 321 105.5 289.5L217.7 177.2c31.5-31.5 82.5-31.5 114 0c27.9 27.9 31.5 71.8 8.6 103.9l-1.1 1.6c-10.3 14.4-6.9 34.4 7.4 44.6s34.4 6.9 44.6-7.4l1.1-1.6C433.5 260.8 427 182 377 132c-56.5-56.5-148-56.5-204.5 0L60.2 244.3z\"\/><\/svg><\/div><\/span><\/a><\/div>\n<\/div><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-divider alignfull stk-block-divider stk--hide-desktop has-text-align-center stk-block stk-108ef6b\" data-block-id=\"108ef6b\"><style>.stk-108ef6b hr.stk-block-divider__hr{background:#abb8c3 !important;}@media screen and (max-width:689px){.stk-108ef6b {align-items:center !important;margin-bottom:0px !important;display:flex !important;}}<\/style><hr class=\"stk-block-divider__hr\"\/><\/div>\n\n\n\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-a2d56a6\" data-block-id=\"a2d56a6\"><style>.stk-a2d56a6 {padding-left:0px !important;margin-bottom:var(--stk--preset--spacing--none, 0px) !important;}.stk-a2d56a6-column{--stk-column-gap:var(--stk--preset--spacing--20, 0.44rem) !important;justify-content:flex-start !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-a2d56a6-column stk--flex\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-4b33d14\" data-v=\"4\" data-block-id=\"4b33d14\"><style>.stk-4b33d14 {min-height:var(--stk--preset--block-height--none, 0px) !important;max-width:1500px !important;min-width:auto !important;padding-left:var(--stk--preset--spacing--none, 0px) !important;margin-right:auto !important;margin-left:var(--stk--preset--spacing--none, 0px) !important;}@media screen and (min-width:690px){.stk-4b33d14 {flex:var(--stk-flex-grow, 1) 1 calc(82% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-4b33d14-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-4b33d14-inner-blocks\">\n<ul class=\"wp-block-list\">\n<li style=\"margin-left:0\">PETRACCA, Yanina L., et al. The late and dual origin of cerebrospinal fluid-contacting neurons in the mouse spinal cord. Development, 2016, vol. 143, no 5, p. 880-891.<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-84af16c\" data-v=\"4\" data-block-id=\"84af16c\"><style>@media screen and (min-width:690px){.stk-84af16c {flex:var(--stk-flex-grow, 1) 1 calc(18% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}@media screen and (max-width:689px){.stk-84af16c-container{margin-left:30px !important;}.stk-84af16c {align-self:center !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-84af16c-container stk--no-background stk--no-padding\"><div class=\"has-text-align-left-mobile stk-block-content stk-inner-blocks stk-84af16c-inner-blocks\">\n<div class=\"wp-block-stackable-button-group stk-block-button-group stk-block stk-ffe44e6\" data-block-id=\"ffe44e6\"><div class=\"stk-row stk-inner-blocks stk-block-content stk-button-group\">\n<div class=\"wp-block-stackable-icon-button stk-block-icon-button stk-block stk-4553922\" data-block-id=\"4553922\"><style>.stk-4553922 .stk-button{background:var(--theme-palette-color-1, #164193) !important;}.stk-4553922 .stk-button:hover{background:var(--theme-palette-color-2, #312a74) !important;opacity:1 !important;}<\/style><a class=\"stk-link stk-button stk--hover-effect-darken\" href=\"https:\/\/journals.biologists.com\/dev\/article-abstract\/143\/5\/880\/47731\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 640 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M579.8 267.7c56.5-56.5 56.5-148 0-204.5c-50-50-128.8-56.5-186.3-15.4l-1.6 1.1c-14.4 10.3-17.7 30.3-7.4 44.6s30.3 17.7 44.6 7.4l1.6-1.1c32.1-22.9 76-19.3 103.8 8.6c31.5 31.5 31.5 82.5 0 114L422.3 334.8c-31.5 31.5-82.5 31.5-114 0c-27.9-27.9-31.5-71.8-8.6-103.8l1.1-1.6c10.3-14.4 6.9-34.4-7.4-44.6s-34.4-6.9-44.6 7.4l-1.1 1.6C206.5 251.2 213 330 263 380c56.5 56.5 148 56.5 204.5 0L579.8 267.7zM60.2 244.3c-56.5 56.5-56.5 148 0 204.5c50 50 128.8 56.5 186.3 15.4l1.6-1.1c14.4-10.3 17.7-30.3 7.4-44.6s-30.3-17.7-44.6-7.4l-1.6 1.1c-32.1 22.9-76 19.3-103.8-8.6C74 372 74 321 105.5 289.5L217.7 177.2c31.5-31.5 82.5-31.5 114 0c27.9 27.9 31.5 71.8 8.6 103.9l-1.1 1.6c-10.3 14.4-6.9 34.4 7.4 44.6s34.4 6.9 44.6-7.4l1.1-1.6C433.5 260.8 427 182 377 132c-56.5-56.5-148-56.5-204.5 0L60.2 244.3z\"\/><\/svg><\/div><\/span><\/a><\/div>\n<\/div><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-divider alignfull stk-block-divider stk--hide-desktop has-text-align-center stk-block stk-00e5827\" data-block-id=\"00e5827\"><style>.stk-00e5827 hr.stk-block-divider__hr{background:#abb8c3 !important;}@media screen and (max-width:689px){.stk-00e5827 {align-items:center !important;margin-bottom:0px !important;display:flex !important;}}<\/style><hr class=\"stk-block-divider__hr\"\/><\/div>\n\n\n\n<div class=\"wp-block-stackable-spacer stk-block-spacer stk--no-padding stk-block stk-a00a56c\" data-block-id=\"a00a56c\"><style>.stk-a00a56c {height:30px !important;}<\/style><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-greenshift-blocks-row-column gspb_row__col--3 gspb_col-id-gsbp-f78c24f\" id=\"gspb_col-id-gsbp-f78c24f\">\n<div class=\"wp-block-stackable-image stk-block-image stk-block stk-f475dab\" data-block-id=\"f475dab\"><style>.stk-f475dab .stk-img-wrapper{width:80% !important;}<\/style><figure><span class=\"stk-img-wrapper stk-image--shape-stretch\"><img loading=\"lazy\" decoding=\"async\" class=\"stk-img wp-image-1154\" src=\"https:\/\/www.leloir.org.ar\/research\/wp-content\/uploads\/2026\/06\/Fil__Lanuza.png\" width=\"400\" height=\"400\" srcset=\"https:\/\/www.leloir.org.ar\/research\/wp-content\/uploads\/2026\/06\/Fil__Lanuza.png 400w, https:\/\/www.leloir.org.ar\/research\/wp-content\/uploads\/2026\/06\/Fil__Lanuza-300x300.png 300w, https:\/\/www.leloir.org.ar\/research\/wp-content\/uploads\/2026\/06\/Fil__Lanuza-150x150.png 150w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/span><\/figure><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-b236174\" data-block-id=\"b236174\"><style>.stk-b236174 {margin-bottom:0px !important;}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #ffffff;\" class=\"stk-highlight\">Principal investigator<\/span><\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-c6eea5f\" id=\"guillermo-lanuza-ph-d\" data-block-id=\"c6eea5f\"><style>.stk-c6eea5f .stk-block-heading__text{line-height:1.2em !important;}<\/style><h4 class=\"stk-block-heading__text\">Guillermo Lanuza, PhD<\/h4><\/div>\n\n\n\n<div class=\"wp-block-stackable-icon-label stk-block-icon-label stk-block stk-920abd0\" data-block-id=\"920abd0\"><style>.stk-920abd0 .stk-inner-blocks{gap:10px !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content\">\n<div class=\"wp-block-stackable-icon stk-block-icon has-text-align-left stk-block stk-dd29c01\" data-block-id=\"dd29c01\"><style>.stk-dd29c01 .stk--svg-wrapper .stk--inner-svg svg:last-child{height:22px !important;width:22px !important;}.stk-dd29c01 .stk--svg-wrapper .stk--inner-svg svg:last-child, .stk-dd29c01 .stk--svg-wrapper .stk--inner-svg svg:last-child :is(g, path, rect, polygon, ellipse){fill:var(--theme-palette-color-5, #35b6b4) !important;}<\/style><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg style=\"height:0;width:0\"><defs><linearGradient id=\"linear-gradient-dd29c01\" x1=\"0\" x2=\"100%\" y1=\"0\" y2=\"0\"><stop offset=\"0%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-dd-29-c-01-color-1)\"><\/stop><stop offset=\"100%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-dd-29-c-01-color-2)\"><\/stop><\/linearGradient><\/defs><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M64 112c-8.8 0-16 7.2-16 16v22.1L220.5 291.7c20.7 17 50.4 17 71.1 0L464 150.1V128c0-8.8-7.2-16-16-16H64zM48 212.2V384c0 8.8 7.2 16 16 16H448c8.8 0 16-7.2 16-16V212.2L322 328.8c-38.4 31.5-93.7 31.5-132 0L48 212.2zM0 128C0 92.7 28.7 64 64 64H448c35.3 0 64 28.7 64 64V384c0 35.3-28.7 64-64 64H64c-35.3 0-64-28.7-64-64V128z\"\/><\/svg><\/div><\/span><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-7b80074\" id=\"a-href-mailto-glanuza-leloir-org-ar-glanuza-leloir-org-ar-a\" data-block-id=\"7b80074\"><style>.stk-7b80074 .stk-block-heading__text{font-size:1.2rem !important;color:var(--theme-palette-color-5, #35b6b4) !important;}@media screen and (max-width:999px){.stk-7b80074 .stk-block-heading__text{font-size:1.2rem !important;}}<\/style><p class=\"stk-block-heading__text has-text-color\"><a href=\"mailto:glanuza@leloir.org.ar\">glanuza@leloir.org.ar<\/a><\/p><\/div>\n<\/div><\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-a0e1fa3\" data-block-id=\"a0e1fa3\"><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-a0e1fa3-column\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-8ec3b2b\" data-v=\"4\" data-block-id=\"8ec3b2b\"><style>@media screen and (min-width:690px){.stk-8ec3b2b {flex:var(--stk-flex-grow, 1) 1 calc(20% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-8ec3b2b-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-8ec3b2b-inner-blocks\">\n<div class=\"wp-block-stackable-icon stk-block-icon stk-block stk-cacdf15\" data-block-id=\"cacdf15\"><style>.stk-cacdf15 .stk--svg-wrapper .stk--inner-svg svg:last-child{height:18px !important;width:18px !important;}.stk-cacdf15 .stk--svg-wrapper .stk--inner-svg svg:last-child, .stk-cacdf15 .stk--svg-wrapper .stk--inner-svg svg:last-child :is(g, path, rect, polygon, ellipse){fill:var(--theme-palette-color-3, #a7a04d) !important;}<\/style><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg style=\"height:0;width:0\"><defs><linearGradient id=\"linear-gradient-cacdf15\" x1=\"0\" x2=\"100%\" y1=\"0\" y2=\"0\"><stop offset=\"0%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-cacdf-15-color-1)\"><\/stop><stop offset=\"100%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-cacdf-15-color-2)\"><\/stop><\/linearGradient><\/defs><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M336 352c97.2 0 176-78.8 176-176S433.2 0 336 0S160 78.8 160 176c0 18.7 2.9 36.8 8.3 53.7L7 391c-4.5 4.5-7 10.6-7 17v80c0 13.3 10.7 24 24 24h80c13.3 0 24-10.7 24-24V448h40c13.3 0 24-10.7 24-24V384h40c6.4 0 12.5-2.5 17-7l33.3-33.3c16.9 5.4 35 8.3 53.7 8.3zM376 96a40 40 0 1 1 0 80 40 40 0 1 1 0-80z\"\/><\/svg><\/div><\/span><\/div>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-0ccde29\" data-v=\"4\" data-block-id=\"0ccde29\"><style>@media screen and (min-width:690px){.stk-0ccde29 {flex:var(--stk-flex-grow, 1) 1 calc(80% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-0ccde29-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-0ccde29-inner-blocks\">\n<ul style=\"padding-right:0;padding-left:0\" class=\"wp-block-list\">\n<li class=\"has-palette-color-3-color has-text-color has-link-color wp-elements-1\" style=\"line-height:1.3\">neuronal and glial specification<br> <\/li>\n\n\n\n<li 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