{"id":1344,"date":"2026-06-29T16:46:43","date_gmt":"2026-06-29T19:46:43","guid":{"rendered":"https:\/\/www.leloir.org.ar\/research\/?page_id=1344"},"modified":"2026-07-08T09:18:07","modified_gmt":"2026-07-08T12:18:07","slug":"identity-and-neural-development","status":"publish","type":"page","link":"https:\/\/www.leloir.org.ar\/research\/identity-and-neural-development\/","title":{"rendered":"identity and neural  development"},"content":{"rendered":"\n<div class=\"wp-block-stackable-spacer stk-block-spacer stk--no-padding stk-block stk-5bf724e\" data-block-id=\"5bf724e\"><style>.stk-5bf724e {height:20px !important;}<\/style><\/div>\n\n\n\n<div class=\"wp-block-greenshift-blocks-container alignfull gspb_container gspb_container-gsbp-c15c419\" id=\"gspb_container-id-gsbp-c15c419\">\n<div class=\"wp-block-greenshift-blocks-row gspb_row gspb_row-id-gsbp-18a8bbc\" id=\"gspb_row-id-gsbp-18a8bbc\"><div class=\"gspb_row__content\"> \n<div class=\"wp-block-greenshift-blocks-row-column gspb_row__col--6 gspb_row__col--xs-9 gspb_col-id-gsbp-1de9e8b\" id=\"gspb_col-id-gsbp-1de9e8b\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-fe81fce\" id=\"strong-research-area-strong\" data-block-id=\"fe81fce\"><style>.stk-fe81fce .stk-block-heading__text{color:var(--theme-palette-color-3, #a7a04d) !important;}@media screen and (max-width:689px){.stk-fe81fce {padding-bottom:0px !important;margin-bottom:0px !important;}}<\/style><h6 class=\"stk-block-heading__text has-text-color\"><strong>Research area<\/strong><\/h6><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-f5d6339\" id=\"strong-research-area-strong\" data-block-id=\"f5d6339\"><style>@media screen and (max-width:689px){.stk-f5d6339 {align-items:flex-start !important;padding-top:0px !important;padding-right:0px !important;padding-bottom:0px !important;padding-left:0px !important;margin-bottom:0px !important;display:flex !important;}}<\/style><h5 class=\"stk-block-heading__text has-text-align-left-mobile\"><strong><strong><strong><strong>Neuroscience<\/strong><\/strong><\/strong><\/strong><\/h5><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-greenshift-blocks-row-column gspb_row__col--6 gspb_row__col--xs-3 gspb_col-id-gsbp-643144c\" id=\"gspb_col-id-gsbp-643144c\">\n<div class=\"wp-block-stackable-image stk-block-image stk-block stk-aaae08c\" data-block-id=\"aaae08c\"><style>@media screen and (max-width:689px){.stk-aaae08c .stk-img-wrapper{width:80% !important;}}<\/style><figure><span class=\"stk-img-wrapper stk-image--shape-stretch\"><img loading=\"lazy\" decoding=\"async\" class=\"stk-img wp-image-1066\" src=\"https:\/\/www.leloir.org.ar\/research\/wp-content\/uploads\/2026\/06\/neuro.png\" width=\"100\" height=\"100\"\/><\/span><\/figure><\/div>\n<\/div>\n <\/div><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-stackable-columns alignfull stk-block-columns stk--hide-mobile stk-block stk-efbfbbe\" data-block-id=\"efbfbbe\"><style>.stk-efbfbbe {margin-bottom:0px !important;top:0px !important;left:0px !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-efbfbbe-column alignfull\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-095be29 stk-block-background\" data-v=\"4\" data-block-id=\"095be29\"><style>.stk-095be29-container{margin-top:var(--stk--preset--spacing--none, 0px) !important;margin-right:var(--stk--preset--spacing--none, 0px) !important;margin-bottom:var(--stk--preset--spacing--none, 0px) !important;margin-left:var(--stk--preset--spacing--none, 0px) !important;min-height:var(--stk--preset--block-height--none, 0px) !important;}.stk-095be29 {align-self:center !important;background-color:var(--theme-palette-color-1, #164193) !important;border-top-right-radius:var(--stk--preset--border-radius--full, 9999px) !important;border-bottom-right-radius:var(--stk--preset--border-radius--full, 9999px) !important;border-bottom-left-radius:var(--stk--preset--border-radius--none, 0px) !important;overflow:hidden !important;min-height:var(--stk--preset--block-height--none, 0px) !important;align-items:center !important;max-width:350px !important;min-width:auto !important;padding-top:var(--stk--preset--spacing--none, 0px) !important;padding-bottom:var(--stk--preset--spacing--none, 0px) !important;padding-left:60px !important;margin-top:var(--stk--preset--spacing--none, 0px) !important;margin-left:0px !important;display:flex !important;}.stk-095be29:before{background-color:var(--theme-palette-color-1, #164193) !important;}@media screen and (min-width:690px){.stk-095be29 {flex:var(--stk-flex-grow, 1) 1 calc(56% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-095be29-container stk--no-background stk--no-padding\"><div class=\"has-text-align-left stk--block-horizontal-flex stk-block-content stk-inner-blocks stk-095be29-inner-blocks\">\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-a3b5388\" data-block-id=\"a3b5388\"><style>.stk-a3b5388 {padding-top:var(--stk--preset--spacing--none, 0px) !important;padding-right:0px !important;padding-bottom:var(--stk--preset--spacing--none, 0px) !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-a3b5388-column\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-ec743fe\" data-v=\"4\" data-block-id=\"ec743fe\"><style>.stk-ec743fe {padding-left:var(--stk--preset--spacing--none, 0px) !important;margin-right:var(--stk--preset--spacing--none, 0px) !important;margin-left:var(--stk--preset--spacing--none, 0px) !important;}.stk-ec743fe-container{padding-left:var(--stk--preset--spacing--none, 0px) !important;}@media screen and (min-width:690px){.stk-ec743fe {flex:var(--stk-flex-grow, 1) 1 calc(66.667% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-ec743fe-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-ec743fe-inner-blocks\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-0108191\" id=\"strong-research-area-strong\" data-block-id=\"0108191\"><style>.stk-0108191 {margin-bottom:0px !important;}.stk-0108191 .stk-block-heading__text{color:var(--theme-palette-color-3, #a7a04d) !important;}<\/style><h6 class=\"stk-block-heading__text has-text-color\"><strong>Research area<\/strong><\/h6><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-0b4b126\" id=\"strong-neuroscience-strong\" data-block-id=\"0b4b126\"><style>.stk-0b4b126 {align-items:flex-start !important;padding-top:var(--stk--preset--spacing--none, 0px) !important;padding-bottom:var(--stk--preset--spacing--none, 0px) !important;margin-top:var(--stk--preset--spacing--none, 0px) !important;margin-bottom:var(--stk--preset--spacing--none, 0px) !important;margin-left:var(--stk--preset--spacing--none, 0px) !important;display:flex !important;}<\/style><h5 class=\"stk-block-heading__text\"><strong>Neuroscience<\/strong><\/h5><\/div>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-4110096\" data-v=\"4\" data-block-id=\"4110096\"><style>.stk-4110096 {align-self:center !important;padding-top:var(--stk--preset--spacing--none, 0px) !important;padding-right:var(--stk--preset--spacing--none, 0px) !important;padding-bottom:var(--stk--preset--spacing--none, 0px) !important;padding-left:var(--stk--preset--spacing--none, 0px) !important;margin-right:var(--stk--preset--spacing--none, 0px) !important;}.stk-4110096-inner-blocks{align-items:center !important;}@media screen and (min-width:690px){.stk-4110096 {flex:var(--stk-flex-grow, 1) 1 calc(33.333% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-4110096-container stk--no-background stk--no-padding\"><div class=\"stk--block-horizontal-flex stk--column-flex stk-block-content stk-inner-blocks stk-4110096-inner-blocks\">\n<div class=\"wp-block-stackable-image stk-block-image stk-block stk-5f46d71\" data-block-id=\"5f46d71\"><style>.stk-5f46d71 .stk-img-wrapper{width:100% !important;}<\/style><figure><span class=\"stk-img-wrapper stk-image--shape-stretch\"><img loading=\"lazy\" decoding=\"async\" class=\"stk-img wp-image-1066\" src=\"https:\/\/www.leloir.org.ar\/research\/wp-content\/uploads\/2026\/06\/neuro.png\" width=\"100\" height=\"100\"\/><\/span><\/figure><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-9284d94\" data-v=\"4\" data-block-id=\"9284d94\"><style>@media screen and (min-width:690px){.stk-9284d94 {flex:var(--stk-flex-grow, 1) 1 calc(44% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-9284d94-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-9284d94-inner-blocks\"><\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-spacer stk-block-spacer stk--no-padding stk-block stk-e4a0b9e\" data-block-id=\"e4a0b9e\"><style>.stk-e4a0b9e {height:30px !important;}<\/style><\/div>\n\n\n\n<div class=\"wp-block-greenshift-blocks-row alignwide gspb_row gspb_row-id-gsbp-22b4991 gspb_row--gutter-20\" id=\"gspb_row-id-gsbp-22b4991\">\n<div class=\"wp-block-greenshift-blocks-row-column gspb_row__col--9 gspb_col-id-gsbp-c9b3f6b\" id=\"gspb_col-id-gsbp-c9b3f6b\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-104d4ac\" id=\"identity-and-neural-development\" data-block-id=\"104d4ac\"><style>.stk-104d4ac {margin-bottom:40px !important;}.stk-104d4ac .stk-block-heading__text{color:var(--theme-palette-color-3, #a7a04d) !important;}<\/style><h2 class=\"stk-block-heading__text has-text-color\">IDENTITY AND NEURAL DEVELOPMENT<\/h2><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-41b44af\" id=\"strong-research-strong\" data-block-id=\"41b44af\"><style>.stk-41b44af .stk-block-heading__text{color:var(--theme-palette-color-1, #164193) !important;}<\/style><h3 class=\"stk-block-heading__text has-text-color\"><strong>Research<\/strong><\/h3><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-bf578d0\" data-block-id=\"bf578d0\"><p class=\"stk-block-text__text\">Neurons in the mammalian brain are a diverse and heterogenous population, critical to the execution of the most sophisticated functions. Their diversity underlies the complexity of the cerebral function, as well as distinct susceptibilities to disease and neurodevelopmental disorders. Our lab is interested in understanding how the collection of different excitatory neurons in the cerebral cortex are generated and how their specificity is established. To address this big and fundamental question we are first focusing on inter and extracellular mechanisms. In one of our new projects we have identified that different classes of neurons express distinct extracellular matrix (ECM) genes and modifiers. We are working to characterize this specificity and its role in the establishment of neuronal identity and the correct neuronal circuits. Given that some of these genes have been associated to neurodevelopmental disorders, such as Autism Spectrum Disorder (ASD), we will also study cell type-specific production of ECM in the context of ASD models. We use the laboratory mouse as our main model system, as it shares with humans most of the processes and cell types occurring during development. We are now incorporating in vitro models of human brain development (organoids), as well as work with human samples to complement and validate our work. Our approaches combine the use of classic and solid developmental neuroscience tools with the use of high-throughput single cell genomics.<\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-bef9c0d\" id=\"strong-skills-amp-tools-strong\" data-block-id=\"bef9c0d\"><style>.stk-bef9c0d .stk-block-heading__text{color:var(--theme-palette-color-1, #164193) !important;}<\/style><h3 class=\"stk-block-heading__text has-text-color\"><strong>Skills &amp; tools<\/strong><\/h3><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-6f973a4\" data-block-id=\"6f973a4\"><p class=\"stk-block-text__text\">We have a strong background in developmental neuroscience using a diverse array of tools and techniques. We have developed a strong expertise on single cell genomics, including single cell RNA sequencing, ATAC sequencing and shared RNA-ATAC sequencing, from tissue preparation, data and library generation, sequencing and data analysis and interpretation. We combine mouse genetics and in utero electroporations to specifically label and perturb cell types and gene expression in vivo in the mouse brain, with temporal and spatial control. Bringing together in vivo perturbations with high-throughput genomic tools, we develop and apply in vivo screening strategies (CRISPR, overexpression) to address questions related to brain development and function. We are implementing the use of human brain organoids, an in vitro model of the developing human brain, for the study of human cortical development and neuronal heterogeneity.<\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-8fb662c\" id=\"strong-collaboration-interests-strong\" data-block-id=\"8fb662c\"><style>.stk-8fb662c {margin-bottom:3px !important;}.stk-8fb662c .stk-block-heading__text{color:var(--theme-palette-color-1, #164193) !important;}<\/style><h3 class=\"stk-block-heading__text has-text-color\"><strong>Collaboration interests<\/strong><\/h3><\/div>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Spatial transcriptomics<\/li>\n\n\n\n<li>Proteomics and glycomics<\/li>\n\n\n\n<li>Human brain genomics and development<\/li>\n\n\n\n<li style=\"margin-bottom:24px\">Live imaging<\/li>\n<\/ul>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-fb4e260\" id=\"strong-selected-publications-strong\" data-block-id=\"fb4e260\"><style>.stk-fb4e260 {margin-bottom:3px !important;}.stk-fb4e260 .stk-block-heading__text{color:var(--theme-palette-color-1, #164193) !important;}<\/style><h3 class=\"stk-block-heading__text has-text-color\"><strong>Selected publications<\/strong><\/h3><\/div>\n\n\n\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-6b0f0e9\" data-block-id=\"6b0f0e9\"><style>.stk-6b0f0e9 {padding-left:0px !important;margin-bottom:var(--stk--preset--spacing--none, 0px) !important;}.stk-6b0f0e9-column{--stk-column-gap:var(--stk--preset--spacing--20, 0.44rem) !important;justify-content:flex-start !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-6b0f0e9-column stk--flex\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-051e83d\" data-v=\"4\" data-block-id=\"051e83d\"><style>.stk-051e83d {min-height:var(--stk--preset--block-height--none, 0px) !important;max-width:1500px !important;min-width:auto !important;padding-left:var(--stk--preset--spacing--none, 0px) !important;margin-right:auto !important;margin-left:var(--stk--preset--spacing--none, 0px) !important;}@media screen and (min-width:690px){.stk-051e83d {flex:var(--stk-flex-grow, 1) 1 calc(82% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-051e83d-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-051e83d-inner-blocks\">\n<ul class=\"wp-block-list\">\n<li style=\"margin-left:0\">DI BELLA, Daniela J., et al. Molecular logic of cellular diversification in the mouse cerebral cortex. Nature, 2021, vol. 595, no 7868, p. 554-559.<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-3edd196\" data-v=\"4\" data-block-id=\"3edd196\"><style>@media screen and (min-width:690px){.stk-3edd196 {flex:var(--stk-flex-grow, 1) 1 calc(18% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}@media screen and (max-width:689px){.stk-3edd196-container{margin-left:30px !important;}.stk-3edd196 {align-self:center !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-3edd196-container stk--no-background stk--no-padding\"><div class=\"has-text-align-left-mobile stk-block-content stk-inner-blocks stk-3edd196-inner-blocks\">\n<div class=\"wp-block-stackable-button-group stk-block-button-group stk-block stk-12c0695\" data-block-id=\"12c0695\"><div class=\"stk-row stk-inner-blocks stk-block-content stk-button-group\">\n<div class=\"wp-block-stackable-icon-button stk-block-icon-button stk-block stk-5f4831a\" data-block-id=\"5f4831a\"><style>.stk-5f4831a .stk-button{background:var(--theme-palette-color-1, #164193) !important;}.stk-5f4831a .stk-button:hover{background:var(--theme-palette-color-2, #312a74) !important;opacity:1 !important;}<\/style><a class=\"stk-link stk-button stk--hover-effect-darken\" href=\"https:\/\/www.nature.com\/articles\/s41586-021-03670-5\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 640 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M579.8 267.7c56.5-56.5 56.5-148 0-204.5c-50-50-128.8-56.5-186.3-15.4l-1.6 1.1c-14.4 10.3-17.7 30.3-7.4 44.6s30.3 17.7 44.6 7.4l1.6-1.1c32.1-22.9 76-19.3 103.8 8.6c31.5 31.5 31.5 82.5 0 114L422.3 334.8c-31.5 31.5-82.5 31.5-114 0c-27.9-27.9-31.5-71.8-8.6-103.8l1.1-1.6c10.3-14.4 6.9-34.4-7.4-44.6s-34.4-6.9-44.6 7.4l-1.1 1.6C206.5 251.2 213 330 263 380c56.5 56.5 148 56.5 204.5 0L579.8 267.7zM60.2 244.3c-56.5 56.5-56.5 148 0 204.5c50 50 128.8 56.5 186.3 15.4l1.6-1.1c14.4-10.3 17.7-30.3 7.4-44.6s-30.3-17.7-44.6-7.4l-1.6 1.1c-32.1 22.9-76 19.3-103.8-8.6C74 372 74 321 105.5 289.5L217.7 177.2c31.5-31.5 82.5-31.5 114 0c27.9 27.9 31.5 71.8 8.6 103.9l-1.1 1.6c-10.3 14.4-6.9 34.4 7.4 44.6s34.4 6.9 44.6-7.4l1.1-1.6C433.5 260.8 427 182 377 132c-56.5-56.5-148-56.5-204.5 0L60.2 244.3z\"\/><\/svg><\/div><\/span><\/a><\/div>\n<\/div><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-divider alignfull stk-block-divider stk--hide-desktop has-text-align-center stk-block stk-6eca555\" data-block-id=\"6eca555\"><style>.stk-6eca555 hr.stk-block-divider__hr{background:#abb8c3 !important;}@media screen and (max-width:689px){.stk-6eca555 {align-items:center !important;margin-bottom:0px !important;display:flex !important;}}<\/style><hr class=\"stk-block-divider__hr\"\/><\/div>\n\n\n\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-bf15457\" data-block-id=\"bf15457\"><style>.stk-bf15457 {padding-left:0px !important;margin-bottom:var(--stk--preset--spacing--none, 0px) !important;}.stk-bf15457-column{--stk-column-gap:var(--stk--preset--spacing--20, 0.44rem) !important;justify-content:flex-start !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-bf15457-column stk--flex\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-82616a0\" data-v=\"4\" data-block-id=\"82616a0\"><style>.stk-82616a0 {min-height:var(--stk--preset--block-height--none, 0px) !important;max-width:1500px !important;min-width:auto !important;padding-left:var(--stk--preset--spacing--none, 0px) !important;margin-right:auto !important;margin-left:var(--stk--preset--spacing--none, 0px) !important;}@media screen and (min-width:690px){.stk-82616a0 {flex:var(--stk-flex-grow, 1) 1 calc(82% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-82616a0-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-82616a0-inner-blocks\">\n<ul class=\"wp-block-list\">\n<li style=\"margin-left:0\">MATHO, Katherine S., et al. Genetic dissection of the glutamatergic neuron system in cerebral cortex. Nature, 2021, vol. 598, no 7879, p. 182-187.<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-8f43baf\" data-v=\"4\" data-block-id=\"8f43baf\"><style>@media screen and (min-width:690px){.stk-8f43baf {flex:var(--stk-flex-grow, 1) 1 calc(18% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}@media screen and (max-width:689px){.stk-8f43baf-container{margin-left:30px !important;}.stk-8f43baf {align-self:center !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-8f43baf-container stk--no-background stk--no-padding\"><div class=\"has-text-align-left-mobile stk-block-content stk-inner-blocks stk-8f43baf-inner-blocks\">\n<div class=\"wp-block-stackable-button-group stk-block-button-group stk-block stk-361a94b\" data-block-id=\"361a94b\"><div class=\"stk-row stk-inner-blocks stk-block-content stk-button-group\">\n<div class=\"wp-block-stackable-icon-button stk-block-icon-button stk-block stk-b97f828\" data-block-id=\"b97f828\"><style>.stk-b97f828 .stk-button{background:var(--theme-palette-color-1, #164193) !important;}.stk-b97f828 .stk-button:hover{background:var(--theme-palette-color-2, #312a74) !important;opacity:1 !important;}<\/style><a class=\"stk-link stk-button stk--hover-effect-darken\" href=\"https:\/\/www.nature.com\/articles\/s41586-021-03955-9\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 640 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M579.8 267.7c56.5-56.5 56.5-148 0-204.5c-50-50-128.8-56.5-186.3-15.4l-1.6 1.1c-14.4 10.3-17.7 30.3-7.4 44.6s30.3 17.7 44.6 7.4l1.6-1.1c32.1-22.9 76-19.3 103.8 8.6c31.5 31.5 31.5 82.5 0 114L422.3 334.8c-31.5 31.5-82.5 31.5-114 0c-27.9-27.9-31.5-71.8-8.6-103.8l1.1-1.6c10.3-14.4 6.9-34.4-7.4-44.6s-34.4-6.9-44.6 7.4l-1.1 1.6C206.5 251.2 213 330 263 380c56.5 56.5 148 56.5 204.5 0L579.8 267.7zM60.2 244.3c-56.5 56.5-56.5 148 0 204.5c50 50 128.8 56.5 186.3 15.4l1.6-1.1c14.4-10.3 17.7-30.3 7.4-44.6s-30.3-17.7-44.6-7.4l-1.6 1.1c-32.1 22.9-76 19.3-103.8-8.6C74 372 74 321 105.5 289.5L217.7 177.2c31.5-31.5 82.5-31.5 114 0c27.9 27.9 31.5 71.8 8.6 103.9l-1.1 1.6c-10.3 14.4-6.9 34.4 7.4 44.6s34.4 6.9 44.6-7.4l1.1-1.6C433.5 260.8 427 182 377 132c-56.5-56.5-148-56.5-204.5 0L60.2 244.3z\"\/><\/svg><\/div><\/span><\/a><\/div>\n<\/div><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-divider alignfull stk-block-divider stk--hide-desktop has-text-align-center stk-block stk-00e5827\" data-block-id=\"00e5827\"><style>.stk-00e5827 hr.stk-block-divider__hr{background:#abb8c3 !important;}@media screen and (max-width:689px){.stk-00e5827 {align-items:center !important;margin-bottom:0px !important;display:flex !important;}}<\/style><hr class=\"stk-block-divider__hr\"\/><\/div>\n\n\n\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-a2d56a6\" data-block-id=\"a2d56a6\"><style>.stk-a2d56a6 {padding-left:0px !important;margin-bottom:var(--stk--preset--spacing--none, 0px) !important;}.stk-a2d56a6-column{--stk-column-gap:var(--stk--preset--spacing--20, 0.44rem) !important;justify-content:flex-start !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-a2d56a6-column stk--flex\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-4b33d14\" data-v=\"4\" data-block-id=\"4b33d14\"><style>.stk-4b33d14 {min-height:var(--stk--preset--block-height--none, 0px) !important;max-width:1500px !important;min-width:auto !important;padding-left:var(--stk--preset--spacing--none, 0px) !important;margin-right:auto !important;margin-left:var(--stk--preset--spacing--none, 0px) !important;}@media screen and (min-width:690px){.stk-4b33d14 {flex:var(--stk-flex-grow, 1) 1 calc(82% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-4b33d14-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-4b33d14-inner-blocks\">\n<ul class=\"wp-block-list\">\n<li style=\"margin-left:0\">DI BELLA, Daniela J., et al. Making Ram\u00f3n y Cajal proud: Development of cell identity and diversity in the cerebral cortex. Neuron, 2024, vol. 112, no 13, p. 2091-2111.<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-84af16c\" data-v=\"4\" data-block-id=\"84af16c\"><style>@media screen and (min-width:690px){.stk-84af16c {flex:var(--stk-flex-grow, 1) 1 calc(18% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}@media screen and (max-width:689px){.stk-84af16c-container{margin-left:30px !important;}.stk-84af16c {align-self:center !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-84af16c-container stk--no-background stk--no-padding\"><div class=\"has-text-align-left-mobile stk-block-content stk-inner-blocks stk-84af16c-inner-blocks\">\n<div class=\"wp-block-stackable-button-group stk-block-button-group stk-block stk-ffe44e6\" data-block-id=\"ffe44e6\"><div class=\"stk-row stk-inner-blocks stk-block-content stk-button-group\">\n<div class=\"wp-block-stackable-icon-button stk-block-icon-button stk-block stk-4553922\" data-block-id=\"4553922\"><style>.stk-4553922 .stk-button{background:var(--theme-palette-color-1, #164193) !important;}.stk-4553922 .stk-button:hover{background:var(--theme-palette-color-2, #312a74) !important;opacity:1 !important;}<\/style><a class=\"stk-link stk-button stk--hover-effect-darken\" href=\"https:\/\/www.cell.com\/neuron\/abstract\/S0896-6273(24)00282-4\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 640 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M579.8 267.7c56.5-56.5 56.5-148 0-204.5c-50-50-128.8-56.5-186.3-15.4l-1.6 1.1c-14.4 10.3-17.7 30.3-7.4 44.6s30.3 17.7 44.6 7.4l1.6-1.1c32.1-22.9 76-19.3 103.8 8.6c31.5 31.5 31.5 82.5 0 114L422.3 334.8c-31.5 31.5-82.5 31.5-114 0c-27.9-27.9-31.5-71.8-8.6-103.8l1.1-1.6c10.3-14.4 6.9-34.4-7.4-44.6s-34.4-6.9-44.6 7.4l-1.1 1.6C206.5 251.2 213 330 263 380c56.5 56.5 148 56.5 204.5 0L579.8 267.7zM60.2 244.3c-56.5 56.5-56.5 148 0 204.5c50 50 128.8 56.5 186.3 15.4l1.6-1.1c14.4-10.3 17.7-30.3 7.4-44.6s-30.3-17.7-44.6-7.4l-1.6 1.1c-32.1 22.9-76 19.3-103.8-8.6C74 372 74 321 105.5 289.5L217.7 177.2c31.5-31.5 82.5-31.5 114 0c27.9 27.9 31.5 71.8 8.6 103.9l-1.1 1.6c-10.3 14.4-6.9 34.4 7.4 44.6s34.4 6.9 44.6-7.4l1.1-1.6C433.5 260.8 427 182 377 132c-56.5-56.5-148-56.5-204.5 0L60.2 244.3z\"\/><\/svg><\/div><\/span><\/a><\/div>\n<\/div><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-divider alignfull stk-block-divider stk--hide-desktop has-text-align-center stk-block stk-eed0992\" data-block-id=\"eed0992\"><style>.stk-eed0992 hr.stk-block-divider__hr{background:#abb8c3 !important;}@media screen and (max-width:689px){.stk-eed0992 {align-items:center !important;margin-bottom:0px !important;display:flex !important;}}<\/style><hr class=\"stk-block-divider__hr\"\/><\/div>\n\n\n\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-c7d591a\" data-block-id=\"c7d591a\"><style>.stk-c7d591a {padding-left:0px !important;margin-bottom:var(--stk--preset--spacing--none, 0px) !important;}.stk-c7d591a-column{--stk-column-gap:var(--stk--preset--spacing--20, 0.44rem) !important;justify-content:flex-start !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-c7d591a-column stk--flex\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-04a249c\" data-v=\"4\" data-block-id=\"04a249c\"><style>.stk-04a249c {min-height:var(--stk--preset--block-height--none, 0px) !important;max-width:1500px !important;min-width:auto !important;padding-left:var(--stk--preset--spacing--none, 0px) !important;margin-right:auto !important;margin-left:var(--stk--preset--spacing--none, 0px) !important;}@media screen and (min-width:690px){.stk-04a249c {flex:var(--stk-flex-grow, 1) 1 calc(82% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-04a249c-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-04a249c-inner-blocks\">\n<ul class=\"wp-block-list\">\n<li style=\"margin-left:0\">ANT\u00d3N-BOLA\u00d1OS, Noelia, et al. Brain Chimeroids reveal individual susceptibility to neurotoxic triggers. Nature, 2024, vol. 631, no 8019, p. 142-149.<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-6350c81\" data-v=\"4\" data-block-id=\"6350c81\"><style>@media screen and (min-width:690px){.stk-6350c81 {flex:var(--stk-flex-grow, 1) 1 calc(18% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-6350c81-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-6350c81-inner-blocks\">\n<div class=\"wp-block-stackable-button-group stk-block-button-group stk-block stk-08577ff\" data-block-id=\"08577ff\"><div class=\"stk-row stk-inner-blocks stk-block-content stk-button-group\">\n<div class=\"wp-block-stackable-icon-button stk-block-icon-button stk-block stk-40f70e0\" data-block-id=\"40f70e0\"><style>.stk-40f70e0 .stk-button{background:var(--theme-palette-color-1, #164193) !important;}.stk-40f70e0 .stk-button:hover{background:var(--theme-palette-color-2, #312a74) !important;opacity:1 !important;}<\/style><a class=\"stk-link stk-button stk--hover-effect-darken\" href=\"https:\/\/www.nature.com\/articles\/s41586-024-07578-8\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 640 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M579.8 267.7c56.5-56.5 56.5-148 0-204.5c-50-50-128.8-56.5-186.3-15.4l-1.6 1.1c-14.4 10.3-17.7 30.3-7.4 44.6s30.3 17.7 44.6 7.4l1.6-1.1c32.1-22.9 76-19.3 103.8 8.6c31.5 31.5 31.5 82.5 0 114L422.3 334.8c-31.5 31.5-82.5 31.5-114 0c-27.9-27.9-31.5-71.8-8.6-103.8l1.1-1.6c10.3-14.4 6.9-34.4-7.4-44.6s-34.4-6.9-44.6 7.4l-1.1 1.6C206.5 251.2 213 330 263 380c56.5 56.5 148 56.5 204.5 0L579.8 267.7zM60.2 244.3c-56.5 56.5-56.5 148 0 204.5c50 50 128.8 56.5 186.3 15.4l1.6-1.1c14.4-10.3 17.7-30.3 7.4-44.6s-30.3-17.7-44.6-7.4l-1.6 1.1c-32.1 22.9-76 19.3-103.8-8.6C74 372 74 321 105.5 289.5L217.7 177.2c31.5-31.5 82.5-31.5 114 0c27.9 27.9 31.5 71.8 8.6 103.9l-1.1 1.6c-10.3 14.4-6.9 34.4 7.4 44.6s34.4 6.9 44.6-7.4l1.1-1.6C433.5 260.8 427 182 377 132c-56.5-56.5-148-56.5-204.5 0L60.2 244.3z\"\/><\/svg><\/div><\/span><\/a><\/div>\n<\/div><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-divider alignfull stk-block-divider stk--hide-desktop has-text-align-center stk-block stk-fafee08\" data-block-id=\"fafee08\"><style>.stk-fafee08 hr.stk-block-divider__hr{background:#abb8c3 !important;}@media screen and (max-width:689px){.stk-fafee08 {align-items:center !important;margin-bottom:0px !important;display:flex !important;}}<\/style><hr class=\"stk-block-divider__hr\"\/><\/div>\n\n\n\n<div class=\"wp-block-stackable-spacer stk-block-spacer stk--no-padding stk-block stk-a00a56c\" data-block-id=\"a00a56c\"><style>.stk-a00a56c {height:30px !important;}<\/style><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-greenshift-blocks-row-column gspb_row__col--3 gspb_col-id-gsbp-f78c24f\" id=\"gspb_col-id-gsbp-f78c24f\">\n<div class=\"wp-block-stackable-image stk-block-image stk-block stk-f475dab\" data-block-id=\"f475dab\"><style>.stk-f475dab .stk-img-wrapper{width:80% !important;}<\/style><figure><span class=\"stk-img-wrapper stk-image--shape-stretch\"><img loading=\"lazy\" decoding=\"async\" class=\"stk-img wp-image-1148\" src=\"https:\/\/www.leloir.org.ar\/research\/wp-content\/uploads\/2026\/06\/Fil__Di-Bella.png\" width=\"400\" height=\"400\" srcset=\"https:\/\/www.leloir.org.ar\/research\/wp-content\/uploads\/2026\/06\/Fil__Di-Bella.png 400w, https:\/\/www.leloir.org.ar\/research\/wp-content\/uploads\/2026\/06\/Fil__Di-Bella-300x300.png 300w, https:\/\/www.leloir.org.ar\/research\/wp-content\/uploads\/2026\/06\/Fil__Di-Bella-150x150.png 150w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/span><\/figure><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-b236174\" data-block-id=\"b236174\"><style>.stk-b236174 {margin-bottom:0px !important;}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #ffffff;\" class=\"stk-highlight\">Principal investigator<\/span><\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-c6eea5f\" id=\"daniela-di-bella\" data-block-id=\"c6eea5f\"><style>.stk-c6eea5f .stk-block-heading__text{line-height:1.2em !important;}<\/style><h4 class=\"stk-block-heading__text\">Daniela Di Bella<\/h4><\/div>\n\n\n\n<div class=\"wp-block-stackable-icon-label stk-block-icon-label stk-block stk-920abd0\" data-block-id=\"920abd0\"><style>.stk-920abd0 .stk-inner-blocks{gap:10px !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content\">\n<div class=\"wp-block-stackable-icon stk-block-icon has-text-align-left stk-block stk-dd29c01\" 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150.1V128c0-8.8-7.2-16-16-16H64zM48 212.2V384c0 8.8 7.2 16 16 16H448c8.8 0 16-7.2 16-16V212.2L322 328.8c-38.4 31.5-93.7 31.5-132 0L48 212.2zM0 128C0 92.7 28.7 64 64 64H448c35.3 0 64 28.7 64 64V384c0 35.3-28.7 64-64 64H64c-35.3 0-64-28.7-64-64V128z\"\/><\/svg><\/div><\/span><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-7b80074\" id=\"a-href-mailto-ddibella-leloir-org-ar-ddibella-leloir-org-ar-a\" data-block-id=\"7b80074\"><style>.stk-7b80074 .stk-block-heading__text{font-size:1.2rem !important;color:var(--theme-palette-color-5, #35b6b4) !important;}@media screen and (max-width:999px){.stk-7b80074 .stk-block-heading__text{font-size:1.2rem !important;}}<\/style><p class=\"stk-block-heading__text has-text-color\"><a href=\"mailto:ddibella@leloir.org.ar\">ddibella@leloir.org.ar<\/a><\/p><\/div>\n<\/div><\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<div class=\"wp-block-stackable-columns 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Neuroscience<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_gspb_post_css":"#gspb_row-id-gsbp-22b4991{justify-content:space-between;margin-top:0;display:flex;flex-wrap:wrap;margin-bottom:0;margin-left:0;padding-left:0}#gspb_row-id-gsbp-22b4991>.gspb_row__content{display:flex;justify-content:space-between;margin:0 auto;width:100%;flex-wrap:wrap}div[id^=gspb_col-id]{box-sizing:border-box;position:relative;padding:var(--gs-row-column-padding, 15px min(3vw, 20px))}#gspb_col-id-gsbp-c9b3f6b.gspb_row__col--9{width:calc(75% - 10px)}@media (max-width:991.98px){#gspb_col-id-gsbp-c9b3f6b.gspb_row__col--9{width:calc(75% - 10px)}}@media (max-width:767.98px){#gspb_col-id-gsbp-c9b3f6b.gspb_row__col--9{width:calc(75% - 10px)}}@media (max-width:575.98px){#gspb_col-id-gsbp-c9b3f6b.gspb_row__col--9{width:100%}}#gspb_col-id-gsbp-f78c24f.gspb_row__col--3{width:calc(25% - 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