{"id":1305,"date":"2026-06-29T12:36:15","date_gmt":"2026-06-29T15:36:15","guid":{"rendered":"https:\/\/www.leloir.org.ar\/research\/?page_id=1305"},"modified":"2026-07-07T11:56:14","modified_gmt":"2026-07-07T14:56:14","slug":"protein-structure-function-and-engineering-laboratory","status":"publish","type":"page","link":"https:\/\/www.leloir.org.ar\/research\/protein-structure-function-and-engineering-laboratory\/","title":{"rendered":"protein structure-function and engineering laboratory"},"content":{"rendered":"\n<div class=\"wp-block-stackable-spacer stk-block-spacer stk--no-padding stk-block stk-66162b7\" id=\"strong-research-area-strong\" data-block-id=\"66162b7\"><style>.stk-66162b7 {height:20px !important;}<\/style><\/div>\n\n\n\n<div class=\"wp-block-greenshift-blocks-container alignfull gspb_container gspb_container-gsbp-c15c419\" id=\"gspb_container-id-gsbp-c15c419\">\n<div class=\"wp-block-greenshift-blocks-row gspb_row gspb_row-id-gsbp-18a8bbc\" id=\"gspb_row-id-gsbp-18a8bbc\"><div class=\"gspb_row__content\"> \n<div class=\"wp-block-greenshift-blocks-row-column gspb_row__col--6 gspb_row__col--xs-9 gspb_col-id-gsbp-1de9e8b\" id=\"gspb_col-id-gsbp-1de9e8b\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-fe81fce\" id=\"strong-research-area-strong\" data-block-id=\"fe81fce\"><style>.stk-fe81fce .stk-block-heading__text{color:var(--theme-palette-color-3, #a7a04d) !important;}@media screen and (max-width:689px){.stk-fe81fce {padding-bottom:0px !important;margin-bottom:0px !important;}}<\/style><h6 class=\"stk-block-heading__text has-text-color\"><strong>Research area<\/strong><\/h6><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-f5d6339\" id=\"strong-research-area-strong\" data-block-id=\"f5d6339\"><style>@media screen and (max-width:689px){.stk-f5d6339 {align-items:flex-start !important;padding-top:0px !important;padding-right:0px !important;padding-bottom:0px !important;padding-left:0px !important;margin-bottom:0px !important;display:flex !important;}}<\/style><h5 class=\"stk-block-heading__text has-text-align-left-mobile\"><strong><strong>Biochemistry and structural biology<\/strong><\/strong><\/h5><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-greenshift-blocks-row-column gspb_row__col--6 gspb_row__col--xs-3 gspb_col-id-gsbp-643144c\" id=\"gspb_col-id-gsbp-643144c\">\n<div class=\"wp-block-stackable-image stk-block-image stk-block stk-aaae08c\" data-block-id=\"aaae08c\"><style>@media screen and (max-width:689px){.stk-aaae08c .stk-img-wrapper{width:70% !important;}}<\/style><figure><span class=\"stk-img-wrapper stk-image--shape-stretch\"><img loading=\"lazy\" decoding=\"async\" class=\"stk-img wp-image-1063\" src=\"https:\/\/www.leloir.org.ar\/research\/wp-content\/uploads\/2026\/06\/Biochemistry.png\" width=\"100\" height=\"100\"\/><\/span><\/figure><\/div>\n<\/div>\n <\/div><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-stackable-columns alignfull stk-block-columns stk--hide-mobile stk-block stk-5e5bfe3\" data-block-id=\"5e5bfe3\"><style>.stk-5e5bfe3 {top:0px !important;left:0px !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-5e5bfe3-column alignfull\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-4ef4e82 stk-block-background\" data-v=\"4\" data-block-id=\"4ef4e82\"><style>.stk-4ef4e82-container{margin-top:var(--stk--preset--spacing--none, 0px) !important;margin-right:var(--stk--preset--spacing--none, 0px) !important;margin-bottom:var(--stk--preset--spacing--none, 0px) !important;margin-left:var(--stk--preset--spacing--none, 0px) !important;min-height:var(--stk--preset--block-height--none, 0px) !important;}.stk-4ef4e82 {align-self:center !important;background-color:var(--theme-palette-color-1, #164193) !important;border-top-right-radius:var(--stk--preset--border-radius--full, 9999px) !important;border-bottom-right-radius:var(--stk--preset--border-radius--full, 9999px) !important;border-bottom-left-radius:var(--stk--preset--border-radius--none, 0px) !important;overflow:hidden !important;min-height:var(--stk--preset--block-height--none, 0px) !important;align-items:center !important;max-width:525px !important;min-width:auto !important;padding-top:var(--stk--preset--spacing--none, 0px) !important;padding-bottom:var(--stk--preset--spacing--none, 0px) !important;padding-left:60px !important;margin-top:var(--stk--preset--spacing--none, 0px) !important;margin-left:0px !important;display:flex !important;}.stk-4ef4e82:before{background-color:var(--theme-palette-color-1, #164193) !important;}@media screen and (min-width:690px){.stk-4ef4e82 {flex:var(--stk-flex-grow, 1) 1 calc(56% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-4ef4e82-container stk--no-background stk--no-padding\"><div class=\"has-text-align-left stk--block-horizontal-flex stk-block-content stk-inner-blocks stk-4ef4e82-inner-blocks\">\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-5ee0490\" data-block-id=\"5ee0490\"><style>.stk-5ee0490 {padding-top:var(--stk--preset--spacing--none, 0px) !important;padding-right:0px !important;padding-bottom:var(--stk--preset--spacing--none, 0px) !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-5ee0490-column\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-c7a375f\" data-v=\"4\" data-block-id=\"c7a375f\"><style>.stk-c7a375f {padding-left:var(--stk--preset--spacing--none, 0px) !important;margin-right:var(--stk--preset--spacing--none, 0px) !important;margin-left:var(--stk--preset--spacing--none, 0px) !important;}.stk-c7a375f-container{padding-left:var(--stk--preset--spacing--none, 0px) !important;}@media screen and (min-width:690px){.stk-c7a375f {flex:var(--stk-flex-grow, 1) 1 calc(81.1% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-c7a375f-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-c7a375f-inner-blocks\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-dd4c5d4\" id=\"strong-research-area-strong\" data-block-id=\"dd4c5d4\"><style>.stk-dd4c5d4 {margin-bottom:0px !important;}.stk-dd4c5d4 .stk-block-heading__text{color:var(--theme-palette-color-3, #a7a04d) !important;}<\/style><h6 class=\"stk-block-heading__text has-text-color\"><strong>Research area<\/strong><\/h6><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-9644f8c\" id=\"strong-biochemistry-and-structural-biology-strong\" data-block-id=\"9644f8c\"><style>.stk-9644f8c {align-items:flex-start !important;padding-top:var(--stk--preset--spacing--none, 0px) !important;padding-bottom:var(--stk--preset--spacing--none, 0px) !important;margin-top:var(--stk--preset--spacing--none, 0px) !important;margin-bottom:var(--stk--preset--spacing--none, 0px) !important;margin-left:var(--stk--preset--spacing--none, 0px) !important;display:flex !important;}<\/style><h5 class=\"stk-block-heading__text\"><strong>Biochemistry and structural biology<\/strong><\/h5><\/div>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-09bc26b\" data-v=\"4\" data-block-id=\"09bc26b\"><style>.stk-09bc26b {align-self:center !important;padding-top:var(--stk--preset--spacing--none, 0px) !important;padding-right:var(--stk--preset--spacing--none, 0px) !important;padding-bottom:var(--stk--preset--spacing--none, 0px) !important;padding-left:var(--stk--preset--spacing--none, 0px) !important;margin-right:var(--stk--preset--spacing--none, 0px) !important;}.stk-09bc26b-inner-blocks{align-items:center !important;}@media screen and (min-width:690px){.stk-09bc26b {flex:var(--stk-flex-grow, 1) 1 calc(18.9% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-09bc26b-container stk--no-background stk--no-padding\"><div class=\"stk--block-horizontal-flex stk--column-flex stk-block-content stk-inner-blocks stk-09bc26b-inner-blocks\">\n<div class=\"wp-block-stackable-image stk-block-image stk-block stk-f3f39b4\" data-block-id=\"f3f39b4\"><style>.stk-f3f39b4 .stk-img-wrapper{width:100% !important;}<\/style><figure><span class=\"stk-img-wrapper stk-image--shape-stretch\"><img loading=\"lazy\" decoding=\"async\" class=\"stk-img wp-image-1063\" src=\"https:\/\/www.leloir.org.ar\/research\/wp-content\/uploads\/2026\/06\/Biochemistry.png\" width=\"100\" height=\"100\"\/><\/span><\/figure><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-091b9de\" data-v=\"4\" data-block-id=\"091b9de\"><style>@media screen and (min-width:690px){.stk-091b9de {flex:var(--stk-flex-grow, 1) 1 calc(44% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-091b9de-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-091b9de-inner-blocks\"><\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-spacer stk-block-spacer stk--no-padding stk-block stk-af0c2a1\" id=\"strong-research-area-strong\" data-block-id=\"af0c2a1\"><style>.stk-af0c2a1 {height:30px !important;}<\/style><\/div>\n\n\n\n<div class=\"wp-block-greenshift-blocks-row alignwide gspb_row gspb_row-id-gsbp-2a38c9f gspb_row--gutter-20\" id=\"gspb_row-id-gsbp-2a38c9f\">\n<div class=\"wp-block-greenshift-blocks-row-column gspb_row__col--9 gspb_col-id-gsbp-2fbf50f\" id=\"gspb_col-id-gsbp-2fbf50f\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-133764c\" id=\"protein-structure-function-and-engineering-laboratory\" data-block-id=\"133764c\"><style>.stk-133764c {margin-bottom:40px !important;}.stk-133764c .stk-block-heading__text{color:var(--theme-palette-color-3, #a7a04d) !important;}<\/style><h2 class=\"stk-block-heading__text has-text-color\">PROTEIN STRUCTURE-FUNCTION AND ENGINEERING LABORATORY<\/h2><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-28e8a58\" id=\"strong-research-strong\" data-block-id=\"28e8a58\"><style>.stk-28e8a58 .stk-block-heading__text{color:var(--theme-palette-color-1, #164193) !important;}<\/style><h3 class=\"stk-block-heading__text has-text-color\"><strong>Research<\/strong><\/h3><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-b332380\" data-block-id=\"b332380\"><p class=\"stk-block-text__text\">Our group has been investigating the molecular mechanisms involving proteins and nucleic acids in two virus models representative of DNA and RNA viruses and both of strong public health impact, and also selected for being minimal biological pathogenic entities. The human papillomavirus (HPV, 8 kbp DNA genome) was the first virus to be associated with cancer and partakes in uterine and oropharyngeal cancers. We have been addressing the biochemical mechanisms involved in oncogenesis (E6 and E7), transcription regulation (E2) and capsid assembly (L1). The respiratory syncytial virus (RSV, 15 kb RNA genome) is responsible for bronchiolitis in infants, immunocompromised and elderly patients. We have been investigating how the key replication proteins (N, P, M2-1, and L) interact and assemble in replication complexes, and the protein responsible for it s anti-interferon activity (NS1). During the last five years both systems led us to investigate their properties to form biomolecular condensates, recently discovered dynamic membraneless structures based on a chemical principle of liquid-liquid phase separation (LLPS), a field that revolutionized our understanding of cellular biochemistry, function and pathology, present in all kingdoms of life. We have dissected the main players and the accessory roles of the viral proteins involved in the assembly of RSV condensates, while other groups showed that viral replication and assembly factories are indeed liquid membraneless condensates. We also investigated the condensation mechanism of the nucleoprotein of SARS CoV2 with RNA. On the HPV front we established a condensation mechanism between the master regulator E2 and the transcriptional regulator p53 related to a replication inhibition mechanism. In doing so, we also determined a strong tendency of p53 itself to form condensates and entering an amyloid pathway, similar to neuropathies, that is being the focus of study as a likely cause of the gain-of-function activity of p53 in triggering cancer, given that it is the most mutated protein in cancer, in 50% of all tumors. We are focusing on p53 amyloids as neoantigens and aim at producing selective antibody tools for the clinic. Current understanding of assembly and modulation of condensates is at the center of fundamental understanding behind physiology and pathology, and provides novel platforms for drug discovery only beginning to emerge.<\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-a654e8d\" id=\"strong-skills-amp-tools-strong\" data-block-id=\"a654e8d\"><style>.stk-a654e8d .stk-block-heading__text{color:var(--theme-palette-color-1, #164193) !important;}<\/style><h3 class=\"stk-block-heading__text has-text-color\"><strong>Skills &amp; tools<\/strong><\/h3><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-260d7c4\" data-block-id=\"260d7c4\"><p class=\"stk-block-text__text\">Our lab is multidisciplinary covering from biochemistry and biophysics to cellular work. We have expertise in high yield expression of recombinant proteins in bacteria, engineering, purification, fragmentation, chemical modification, and peptides. Analytical tools include UV, fluorescence, circular dichroism, stopped-flow and NMR spectroscopies. In addition, reversed phase HPLC, SEC-MALS, dynamic light scattering (DLS), Isothermal titration calorimetry (ITC). We also have expertise in murine monoclonal antibody production, fine screening, high yield purification, analytical development, immunochemistry, immunohistochemistry, ELISA and so forth. We also work with eukaryotic transfection models, virus titration, infection (RSV), and immunofluorescence as well as quantitative advanced fluorescence and brightfield microscopy.<\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-5168ba6\" id=\"strong-collaboration-interests-strong\" data-block-id=\"5168ba6\"><style>.stk-5168ba6 {margin-bottom:3px !important;}.stk-5168ba6 .stk-block-heading__text{color:var(--theme-palette-color-1, #164193) !important;}<\/style><h3 class=\"stk-block-heading__text has-text-color\"><strong>Collaboration interests<\/strong><\/h3><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-cecdfaf\" id=\"strong-span-style-color-var-theme-palette-color-6-4-d-4-d-4-d-class-stk-highlight-academia-span-strong\" data-block-id=\"cecdfaf\"><style>.stk-cecdfaf {margin-bottom:0px !important;}.stk-cecdfaf .stk-block-heading__text{color:var(--theme-palette-color-1, #164193) !important;}<\/style><h5 class=\"stk-block-heading__text has-text-color\"><strong><span style=\"color: var(--theme-palette-color-6, #4d4d4d);\" class=\"stk-highlight\">Academia<\/span><\/strong><\/h5><\/div>\n\n\n\n<ul id=\"strong-span-style-color-var-theme-palette-color-6-4-d-4-d-4-d-class-stk-highlight-academia-span-strong\" class=\"wp-block-list\">\n<li>Transmission and cryoelectron microscopy<\/li>\n\n\n\n<li>Virus biology<\/li>\n\n\n\n<li>p53 cancer models<\/li>\n\n\n\n<li>Physics of biomolecular condensation<\/li>\n<\/ul>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-f495b7f\" id=\"strong-span-style-color-var-theme-palette-color-6-4-d-4-d-4-d-class-stk-highlight-industry-span-strong\" data-block-id=\"f495b7f\"><style>.stk-f495b7f {margin-bottom:0px !important;}.stk-f495b7f .stk-block-heading__text{color:var(--theme-palette-color-1, #164193) !important;}<\/style><h5 class=\"stk-block-heading__text has-text-color\"><strong><span style=\"color: var(--theme-palette-color-6, #4d4d4d);\" class=\"stk-highlight\">Industry<\/span><\/strong><\/h5><\/div>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Protein, enzyme, peptide and nucleic acid related projects with the biotech sector<\/li>\n\n\n\n<li>Services for protein and biomolecule analysis<\/li>\n\n\n\n<li>Novel antibody developments for diagnostics<\/li>\n\n\n\n<li>Biomolecular condensates based drug discovery platforms<\/li>\n<\/ul>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-341a9f4\" id=\"strong-selected-publications-strong\" data-block-id=\"341a9f4\"><style>.stk-341a9f4 {margin-bottom:3px !important;}.stk-341a9f4 .stk-block-heading__text{color:var(--theme-palette-color-1, #164193) !important;}<\/style><h3 class=\"stk-block-heading__text has-text-color\"><strong>Selected publications<\/strong><\/h3><\/div>\n\n\n\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-193dbfa\" data-block-id=\"193dbfa\"><style>.stk-193dbfa {padding-left:0px !important;margin-bottom:var(--stk--preset--spacing--none, 0px) !important;}.stk-193dbfa-column{--stk-column-gap:var(--stk--preset--spacing--20, 0.44rem) !important;justify-content:flex-start !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-193dbfa-column stk--flex\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-f6f2387\" data-v=\"4\" data-block-id=\"f6f2387\"><style>.stk-f6f2387 {min-height:var(--stk--preset--block-height--none, 0px) !important;max-width:1500px !important;min-width:auto !important;padding-left:var(--stk--preset--spacing--none, 0px) !important;margin-right:auto !important;margin-left:var(--stk--preset--spacing--none, 0px) !important;}@media screen and (min-width:690px){.stk-f6f2387 {flex:var(--stk-flex-grow, 1) 1 calc(82% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-f6f2387-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-f6f2387-inner-blocks\">\n<ul class=\"wp-block-list\">\n<li style=\"margin-left:0\">BORKOSKY, Silvia S., et al. Experimental kinetic mechanism of P53 condensation-amyloid aggregation. Biophysical Journal, 2025, vol. 124, no 10, p. 1658-1673.<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-5a33621\" data-v=\"4\" data-block-id=\"5a33621\"><style>@media screen and (min-width:690px){.stk-5a33621 {flex:var(--stk-flex-grow, 1) 1 calc(18% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-5a33621-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-5a33621-inner-blocks\">\n<div class=\"wp-block-stackable-button-group stk-block-button-group stk-block stk-b873c6a\" data-block-id=\"b873c6a\"><div class=\"stk-row stk-inner-blocks stk-block-content stk-button-group\">\n<div class=\"wp-block-stackable-icon-button stk-block-icon-button stk-block stk-776b4f5\" data-block-id=\"776b4f5\"><style>.stk-776b4f5 .stk-button{background:var(--theme-palette-color-1, #164193) !important;}.stk-776b4f5 .stk-button:hover{background:var(--theme-palette-color-2, #312a74) !important;opacity:1 !important;}<\/style><a class=\"stk-link stk-button stk--hover-effect-darken\" href=\"https:\/\/www.cell.com\/biophysj\/abstract\/S0006-3495(25)00236-X\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 640 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M579.8 267.7c56.5-56.5 56.5-148 0-204.5c-50-50-128.8-56.5-186.3-15.4l-1.6 1.1c-14.4 10.3-17.7 30.3-7.4 44.6s30.3 17.7 44.6 7.4l1.6-1.1c32.1-22.9 76-19.3 103.8 8.6c31.5 31.5 31.5 82.5 0 114L422.3 334.8c-31.5 31.5-82.5 31.5-114 0c-27.9-27.9-31.5-71.8-8.6-103.8l1.1-1.6c10.3-14.4 6.9-34.4-7.4-44.6s-34.4-6.9-44.6 7.4l-1.1 1.6C206.5 251.2 213 330 263 380c56.5 56.5 148 56.5 204.5 0L579.8 267.7zM60.2 244.3c-56.5 56.5-56.5 148 0 204.5c50 50 128.8 56.5 186.3 15.4l1.6-1.1c14.4-10.3 17.7-30.3 7.4-44.6s-30.3-17.7-44.6-7.4l-1.6 1.1c-32.1 22.9-76 19.3-103.8-8.6C74 372 74 321 105.5 289.5L217.7 177.2c31.5-31.5 82.5-31.5 114 0c27.9 27.9 31.5 71.8 8.6 103.9l-1.1 1.6c-10.3 14.4-6.9 34.4 7.4 44.6s34.4 6.9 44.6-7.4l1.1-1.6C433.5 260.8 427 182 377 132c-56.5-56.5-148-56.5-204.5 0L60.2 244.3z\"\/><\/svg><\/div><\/span><\/a><\/div>\n<\/div><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-divider alignfull stk-block-divider stk--hide-desktop has-text-align-center stk-block stk-504829f\" data-block-id=\"504829f\"><style>.stk-504829f hr.stk-block-divider__hr{background:#abb8c3 !important;}@media screen and (max-width:689px){.stk-504829f {align-items:center !important;margin-bottom:0px !important;display:flex !important;}}<\/style><hr class=\"stk-block-divider__hr\"\/><\/div>\n\n\n\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-5a54113\" data-block-id=\"5a54113\"><style>.stk-5a54113 {padding-left:0px !important;margin-bottom:var(--stk--preset--spacing--none, 0px) !important;}.stk-5a54113-column{--stk-column-gap:var(--stk--preset--spacing--20, 0.44rem) !important;justify-content:flex-start !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-5a54113-column stk--flex\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-4e5e1c5\" data-v=\"4\" data-block-id=\"4e5e1c5\"><style>.stk-4e5e1c5 {min-height:var(--stk--preset--block-height--none, 0px) !important;max-width:1500px !important;min-width:auto !important;padding-left:var(--stk--preset--spacing--none, 0px) !important;margin-right:auto !important;margin-left:var(--stk--preset--spacing--none, 0px) !important;}@media screen and (min-width:690px){.stk-4e5e1c5 {flex:var(--stk-flex-grow, 1) 1 calc(82% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-4e5e1c5-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-4e5e1c5-inner-blocks\">\n<ul class=\"wp-block-list\">\n<li style=\"margin-left:0\">PERALTA\u2010MARTINEZ, Ramon, et al. Protein\u2013RNA condensation kinetics via filamentous nanoclusters. Protein Science, 2025, vol. 34, no 6, p. e70136.<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-ef8479e\" data-v=\"4\" data-block-id=\"ef8479e\"><style>@media screen and (min-width:690px){.stk-ef8479e {flex:var(--stk-flex-grow, 1) 1 calc(18% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-ef8479e-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-ef8479e-inner-blocks\">\n<div class=\"wp-block-stackable-button-group stk-block-button-group stk-block stk-98399e6\" data-block-id=\"98399e6\"><div class=\"stk-row stk-inner-blocks stk-block-content stk-button-group\">\n<div class=\"wp-block-stackable-icon-button stk-block-icon-button stk-block stk-edb2ba1\" data-block-id=\"edb2ba1\"><style>.stk-edb2ba1 .stk-button{background:var(--theme-palette-color-1, #164193) !important;}.stk-edb2ba1 .stk-button:hover{background:var(--theme-palette-color-2, #312a74) !important;opacity:1 !important;}<\/style><a class=\"stk-link stk-button stk--hover-effect-darken\" href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1002\/pro.70136\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 640 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M579.8 267.7c56.5-56.5 56.5-148 0-204.5c-50-50-128.8-56.5-186.3-15.4l-1.6 1.1c-14.4 10.3-17.7 30.3-7.4 44.6s30.3 17.7 44.6 7.4l1.6-1.1c32.1-22.9 76-19.3 103.8 8.6c31.5 31.5 31.5 82.5 0 114L422.3 334.8c-31.5 31.5-82.5 31.5-114 0c-27.9-27.9-31.5-71.8-8.6-103.8l1.1-1.6c10.3-14.4 6.9-34.4-7.4-44.6s-34.4-6.9-44.6 7.4l-1.1 1.6C206.5 251.2 213 330 263 380c56.5 56.5 148 56.5 204.5 0L579.8 267.7zM60.2 244.3c-56.5 56.5-56.5 148 0 204.5c50 50 128.8 56.5 186.3 15.4l1.6-1.1c14.4-10.3 17.7-30.3 7.4-44.6s-30.3-17.7-44.6-7.4l-1.6 1.1c-32.1 22.9-76 19.3-103.8-8.6C74 372 74 321 105.5 289.5L217.7 177.2c31.5-31.5 82.5-31.5 114 0c27.9 27.9 31.5 71.8 8.6 103.9l-1.1 1.6c-10.3 14.4-6.9 34.4 7.4 44.6s34.4 6.9 44.6-7.4l1.1-1.6C433.5 260.8 427 182 377 132c-56.5-56.5-148-56.5-204.5 0L60.2 244.3z\"\/><\/svg><\/div><\/span><\/a><\/div>\n<\/div><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-divider alignfull stk-block-divider stk--hide-desktop has-text-align-center stk-block stk-43e3259\" data-block-id=\"43e3259\"><style>.stk-43e3259 hr.stk-block-divider__hr{background:#abb8c3 !important;}@media screen and (max-width:689px){.stk-43e3259 {align-items:center !important;margin-bottom:0px !important;display:flex !important;}}<\/style><hr class=\"stk-block-divider__hr\"\/><\/div>\n\n\n\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-2cc98fc\" data-block-id=\"2cc98fc\"><style>.stk-2cc98fc {padding-left:0px !important;margin-bottom:var(--stk--preset--spacing--none, 0px) !important;}.stk-2cc98fc-column{--stk-column-gap:var(--stk--preset--spacing--20, 0.44rem) !important;justify-content:flex-start !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-2cc98fc-column stk--flex\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-2d73e22\" data-v=\"4\" data-block-id=\"2d73e22\"><style>.stk-2d73e22 {min-height:var(--stk--preset--block-height--none, 0px) !important;max-width:1500px !important;min-width:auto !important;padding-left:var(--stk--preset--spacing--none, 0px) !important;margin-right:auto !important;margin-left:var(--stk--preset--spacing--none, 0px) !important;}@media screen and (min-width:690px){.stk-2d73e22 {flex:var(--stk-flex-grow, 1) 1 calc(82% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-2d73e22-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-2d73e22-inner-blocks\">\n<ul class=\"wp-block-list\">\n<li style=\"margin-left:0\">VISENTIN, Araceli, et al. Assembly of the tripartite and RNA condensates of the respiratory syncytial virus factory proteins in vitro: role of the transcription antiterminator M2-1. Viruses, 2023, vol. 15, no 6, p. 1329<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-7f13117\" data-v=\"4\" data-block-id=\"7f13117\"><style>@media screen and (min-width:690px){.stk-7f13117 {flex:var(--stk-flex-grow, 1) 1 calc(18% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-7f13117-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-7f13117-inner-blocks\">\n<div class=\"wp-block-stackable-button-group stk-block-button-group stk-block stk-d13ba5c\" data-block-id=\"d13ba5c\"><div class=\"stk-row stk-inner-blocks stk-block-content stk-button-group\">\n<div class=\"wp-block-stackable-icon-button stk-block-icon-button stk-block stk-043b817\" data-block-id=\"043b817\"><style>.stk-043b817 .stk-button{background:var(--theme-palette-color-1, #164193) !important;}.stk-043b817 .stk-button:hover{background:var(--theme-palette-color-2, #312a74) !important;opacity:1 !important;}<\/style><a class=\"stk-link stk-button stk--hover-effect-darken\" href=\"https:\/\/www.mdpi.com\/1999-4915\/15\/6\/1329\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 640 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M579.8 267.7c56.5-56.5 56.5-148 0-204.5c-50-50-128.8-56.5-186.3-15.4l-1.6 1.1c-14.4 10.3-17.7 30.3-7.4 44.6s30.3 17.7 44.6 7.4l1.6-1.1c32.1-22.9 76-19.3 103.8 8.6c31.5 31.5 31.5 82.5 0 114L422.3 334.8c-31.5 31.5-82.5 31.5-114 0c-27.9-27.9-31.5-71.8-8.6-103.8l1.1-1.6c10.3-14.4 6.9-34.4-7.4-44.6s-34.4-6.9-44.6 7.4l-1.1 1.6C206.5 251.2 213 330 263 380c56.5 56.5 148 56.5 204.5 0L579.8 267.7zM60.2 244.3c-56.5 56.5-56.5 148 0 204.5c50 50 128.8 56.5 186.3 15.4l1.6-1.1c14.4-10.3 17.7-30.3 7.4-44.6s-30.3-17.7-44.6-7.4l-1.6 1.1c-32.1 22.9-76 19.3-103.8-8.6C74 372 74 321 105.5 289.5L217.7 177.2c31.5-31.5 82.5-31.5 114 0c27.9 27.9 31.5 71.8 8.6 103.9l-1.1 1.6c-10.3 14.4-6.9 34.4 7.4 44.6s34.4 6.9 44.6-7.4l1.1-1.6C433.5 260.8 427 182 377 132c-56.5-56.5-148-56.5-204.5 0L60.2 244.3z\"\/><\/svg><\/div><\/span><\/a><\/div>\n<\/div><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-divider alignfull stk-block-divider stk--hide-desktop has-text-align-center stk-block stk-f9149a7\" data-block-id=\"f9149a7\"><style>.stk-f9149a7 hr.stk-block-divider__hr{background:#abb8c3 !important;}@media screen and (max-width:689px){.stk-f9149a7 {align-items:center !important;margin-bottom:0px !important;display:flex !important;}}<\/style><hr class=\"stk-block-divider__hr\"\/><\/div>\n\n\n\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-678ef06\" data-block-id=\"678ef06\"><style>.stk-678ef06 {padding-left:0px !important;margin-bottom:var(--stk--preset--spacing--none, 0px) !important;}.stk-678ef06-column{--stk-column-gap:var(--stk--preset--spacing--20, 0.44rem) !important;justify-content:flex-start !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-678ef06-column stk--flex\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-03b41f2\" data-v=\"4\" data-block-id=\"03b41f2\"><style>.stk-03b41f2 {min-height:var(--stk--preset--block-height--none, 0px) !important;max-width:1500px !important;min-width:auto !important;padding-left:var(--stk--preset--spacing--none, 0px) !important;margin-right:auto !important;margin-left:var(--stk--preset--spacing--none, 0px) !important;}@media screen and (min-width:690px){.stk-03b41f2 {flex:var(--stk-flex-grow, 1) 1 calc(82% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-03b41f2-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-03b41f2-inner-blocks\">\n<ul class=\"wp-block-list\">\n<li style=\"margin-left:0\">SALGUEIRO, Mariano, et al. Molten globule driven and self-downmodulated phase separation of a viral factory scaffold. Journal of Molecular Biology, 2023, vol. 435, no 16, p. 168153.<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-f5e8620\" data-v=\"4\" data-block-id=\"f5e8620\"><style>@media screen and (min-width:690px){.stk-f5e8620 {flex:var(--stk-flex-grow, 1) 1 calc(18% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}@media screen and (max-width:689px){.stk-f5e8620-container{margin-left:30px !important;}.stk-f5e8620 {align-self:center !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-f5e8620-container stk--no-background stk--no-padding\"><div class=\"has-text-align-left-mobile stk-block-content stk-inner-blocks stk-f5e8620-inner-blocks\">\n<div class=\"wp-block-stackable-button-group stk-block-button-group stk-block stk-7bc69c2\" data-block-id=\"7bc69c2\"><div class=\"stk-row stk-inner-blocks stk-block-content stk-button-group\">\n<div class=\"wp-block-stackable-icon-button stk-block-icon-button stk-block stk-493f343\" data-block-id=\"493f343\"><style>.stk-493f343 .stk-button{background:var(--theme-palette-color-1, #164193) !important;}.stk-493f343 .stk-button:hover{background:var(--theme-palette-color-2, #312a74) !important;opacity:1 !important;}<\/style><a class=\"stk-link stk-button stk--hover-effect-darken\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0022283623002383\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 640 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M579.8 267.7c56.5-56.5 56.5-148 0-204.5c-50-50-128.8-56.5-186.3-15.4l-1.6 1.1c-14.4 10.3-17.7 30.3-7.4 44.6s30.3 17.7 44.6 7.4l1.6-1.1c32.1-22.9 76-19.3 103.8 8.6c31.5 31.5 31.5 82.5 0 114L422.3 334.8c-31.5 31.5-82.5 31.5-114 0c-27.9-27.9-31.5-71.8-8.6-103.8l1.1-1.6c10.3-14.4 6.9-34.4-7.4-44.6s-34.4-6.9-44.6 7.4l-1.1 1.6C206.5 251.2 213 330 263 380c56.5 56.5 148 56.5 204.5 0L579.8 267.7zM60.2 244.3c-56.5 56.5-56.5 148 0 204.5c50 50 128.8 56.5 186.3 15.4l1.6-1.1c14.4-10.3 17.7-30.3 7.4-44.6s-30.3-17.7-44.6-7.4l-1.6 1.1c-32.1 22.9-76 19.3-103.8-8.6C74 372 74 321 105.5 289.5L217.7 177.2c31.5-31.5 82.5-31.5 114 0c27.9 27.9 31.5 71.8 8.6 103.9l-1.1 1.6c-10.3 14.4-6.9 34.4 7.4 44.6s34.4 6.9 44.6-7.4l1.1-1.6C433.5 260.8 427 182 377 132c-56.5-56.5-148-56.5-204.5 0L60.2 244.3z\"\/><\/svg><\/div><\/span><\/a><\/div>\n<\/div><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-divider alignfull stk-block-divider stk--hide-desktop has-text-align-center stk-block stk-542184a\" data-block-id=\"542184a\"><style>.stk-542184a hr.stk-block-divider__hr{background:#abb8c3 !important;}@media screen and (max-width:689px){.stk-542184a {align-items:center !important;margin-bottom:0px !important;display:flex !important;}}<\/style><hr class=\"stk-block-divider__hr\"\/><\/div>\n\n\n\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-ed5566f\" data-block-id=\"ed5566f\"><style>.stk-ed5566f {padding-left:0px !important;margin-bottom:var(--stk--preset--spacing--none, 0px) !important;}.stk-ed5566f-column{--stk-column-gap:var(--stk--preset--spacing--20, 0.44rem) !important;justify-content:flex-start !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-ed5566f-column stk--flex\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-09dc175\" data-v=\"4\" data-block-id=\"09dc175\"><style>.stk-09dc175 {min-height:var(--stk--preset--block-height--none, 0px) !important;max-width:1500px !important;min-width:auto !important;padding-left:var(--stk--preset--spacing--none, 0px) !important;margin-right:auto !important;margin-left:var(--stk--preset--spacing--none, 0px) !important;}@media screen and (min-width:690px){.stk-09dc175 {flex:var(--stk-flex-grow, 1) 1 calc(82% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-09dc175-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-09dc175-inner-blocks\">\n<ul class=\"wp-block-list\">\n<li style=\"margin-left:0\">SUSANA BORKOSKY, Silvia, et al. Biomolecular Condensation of the Human Papillomavirus E2 Master Regulator with p53: Implications in Viral Replication. Journal of Molecular Biology.<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-4d244bb\" data-v=\"4\" data-block-id=\"4d244bb\"><style>@media screen and (min-width:690px){.stk-4d244bb {flex:var(--stk-flex-grow, 1) 1 calc(18% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}@media screen and (max-width:689px){.stk-4d244bb-container{margin-left:30px !important;}.stk-4d244bb {align-self:center !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-4d244bb-container stk--no-background stk--no-padding\"><div class=\"has-text-align-left-mobile stk-block-content stk-inner-blocks stk-4d244bb-inner-blocks\">\n<div class=\"wp-block-stackable-button-group stk-block-button-group stk-block stk-b19f698\" data-block-id=\"b19f698\"><div class=\"stk-row stk-inner-blocks stk-block-content stk-button-group\">\n<div class=\"wp-block-stackable-icon-button stk-block-icon-button stk-block stk-3c609b6\" data-block-id=\"3c609b6\"><style>.stk-3c609b6 .stk-button{background:var(--theme-palette-color-1, #164193) !important;}.stk-3c609b6 .stk-button:hover{background:var(--theme-palette-color-2, #312a74) !important;opacity:1 !important;}<\/style><a class=\"stk-link stk-button stk--hover-effect-darken\" href=\"https:\/\/nottingham-repository.worktribe.com\/output\/14587983\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 640 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M579.8 267.7c56.5-56.5 56.5-148 0-204.5c-50-50-128.8-56.5-186.3-15.4l-1.6 1.1c-14.4 10.3-17.7 30.3-7.4 44.6s30.3 17.7 44.6 7.4l1.6-1.1c32.1-22.9 76-19.3 103.8 8.6c31.5 31.5 31.5 82.5 0 114L422.3 334.8c-31.5 31.5-82.5 31.5-114 0c-27.9-27.9-31.5-71.8-8.6-103.8l1.1-1.6c10.3-14.4 6.9-34.4-7.4-44.6s-34.4-6.9-44.6 7.4l-1.1 1.6C206.5 251.2 213 330 263 380c56.5 56.5 148 56.5 204.5 0L579.8 267.7zM60.2 244.3c-56.5 56.5-56.5 148 0 204.5c50 50 128.8 56.5 186.3 15.4l1.6-1.1c14.4-10.3 17.7-30.3 7.4-44.6s-30.3-17.7-44.6-7.4l-1.6 1.1c-32.1 22.9-76 19.3-103.8-8.6C74 372 74 321 105.5 289.5L217.7 177.2c31.5-31.5 82.5-31.5 114 0c27.9 27.9 31.5 71.8 8.6 103.9l-1.1 1.6c-10.3 14.4-6.9 34.4 7.4 44.6s34.4 6.9 44.6-7.4l1.1-1.6C433.5 260.8 427 182 377 132c-56.5-56.5-148-56.5-204.5 0L60.2 244.3z\"\/><\/svg><\/div><\/span><\/a><\/div>\n<\/div><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-divider alignfull stk-block-divider stk--hide-desktop has-text-align-center stk-block stk-c1a95fa\" data-block-id=\"c1a95fa\"><style>.stk-c1a95fa hr.stk-block-divider__hr{background:#abb8c3 !important;}@media screen and (max-width:689px){.stk-c1a95fa {align-items:center !important;margin-bottom:0px !important;display:flex !important;}}<\/style><hr class=\"stk-block-divider__hr\"\/><\/div>\n\n\n\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-884dd1d\" data-block-id=\"884dd1d\"><style>.stk-884dd1d {padding-left:0px !important;margin-bottom:var(--stk--preset--spacing--none, 0px) !important;}.stk-884dd1d-column{--stk-column-gap:var(--stk--preset--spacing--20, 0.44rem) !important;justify-content:flex-start !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-884dd1d-column stk--flex\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-375bbe9\" data-v=\"4\" data-block-id=\"375bbe9\"><style>.stk-375bbe9 {min-height:var(--stk--preset--block-height--none, 0px) !important;max-width:1500px !important;min-width:auto !important;padding-left:var(--stk--preset--spacing--none, 0px) !important;margin-right:auto !important;margin-left:var(--stk--preset--spacing--none, 0px) !important;}@media screen and (min-width:690px){.stk-375bbe9 {flex:var(--stk-flex-grow, 1) 1 calc(82% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-375bbe9-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-375bbe9-inner-blocks\">\n<ul class=\"wp-block-list\">\n<li style=\"margin-left:0\">LOPEZ, Nora, et al. Deconstructing virus condensation. PLoS pathogens, 2021, vol. 17, no 10, p. e1009926.<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-292a269\" data-v=\"4\" data-block-id=\"292a269\"><style>@media screen and (min-width:690px){.stk-292a269 {flex:var(--stk-flex-grow, 1) 1 calc(18% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}@media screen and (max-width:689px){.stk-292a269-container{margin-left:30px !important;}.stk-292a269 {align-self:center !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-292a269-container stk--no-background stk--no-padding\"><div class=\"has-text-align-left-mobile stk-block-content stk-inner-blocks stk-292a269-inner-blocks\">\n<div class=\"wp-block-stackable-button-group stk-block-button-group stk-block stk-a644aea\" data-block-id=\"a644aea\"><div class=\"stk-row stk-inner-blocks stk-block-content stk-button-group\">\n<div class=\"wp-block-stackable-icon-button stk-block-icon-button stk-block stk-fe1cba9\" data-block-id=\"fe1cba9\"><style>.stk-fe1cba9 .stk-button{background:var(--theme-palette-color-1, #164193) !important;}.stk-fe1cba9 .stk-button:hover{background:var(--theme-palette-color-2, #312a74) !important;opacity:1 !important;}<\/style><a class=\"stk-link stk-button stk--hover-effect-darken\" href=\"https:\/\/journals.plos.org\/plospathogens\/article?id=10.1371\/journal.ppat.1009926\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 640 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M579.8 267.7c56.5-56.5 56.5-148 0-204.5c-50-50-128.8-56.5-186.3-15.4l-1.6 1.1c-14.4 10.3-17.7 30.3-7.4 44.6s30.3 17.7 44.6 7.4l1.6-1.1c32.1-22.9 76-19.3 103.8 8.6c31.5 31.5 31.5 82.5 0 114L422.3 334.8c-31.5 31.5-82.5 31.5-114 0c-27.9-27.9-31.5-71.8-8.6-103.8l1.1-1.6c10.3-14.4 6.9-34.4-7.4-44.6s-34.4-6.9-44.6 7.4l-1.1 1.6C206.5 251.2 213 330 263 380c56.5 56.5 148 56.5 204.5 0L579.8 267.7zM60.2 244.3c-56.5 56.5-56.5 148 0 204.5c50 50 128.8 56.5 186.3 15.4l1.6-1.1c14.4-10.3 17.7-30.3 7.4-44.6s-30.3-17.7-44.6-7.4l-1.6 1.1c-32.1 22.9-76 19.3-103.8-8.6C74 372 74 321 105.5 289.5L217.7 177.2c31.5-31.5 82.5-31.5 114 0c27.9 27.9 31.5 71.8 8.6 103.9l-1.1 1.6c-10.3 14.4-6.9 34.4 7.4 44.6s34.4 6.9 44.6-7.4l1.1-1.6C433.5 260.8 427 182 377 132c-56.5-56.5-148-56.5-204.5 0L60.2 244.3z\"\/><\/svg><\/div><\/span><\/a><\/div>\n<\/div><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-divider alignfull stk-block-divider stk--hide-desktop has-text-align-center stk-block stk-5749c12\" data-block-id=\"5749c12\"><style>.stk-5749c12 hr.stk-block-divider__hr{background:#abb8c3 !important;}@media screen and (max-width:689px){.stk-5749c12 {align-items:center !important;margin-bottom:0px !important;display:flex !important;}}<\/style><hr class=\"stk-block-divider__hr\"\/><\/div>\n\n\n\n<div class=\"wp-block-stackable-spacer stk-block-spacer stk--no-padding stk-block stk-d155756\" data-block-id=\"d155756\"><style>.stk-d155756 {height:30px !important;}<\/style><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-greenshift-blocks-row-column gspb_row__col--3 gspb_col-id-gsbp-6a5e99e\" id=\"gspb_col-id-gsbp-6a5e99e\">\n<div class=\"wp-block-stackable-image stk-block-image stk-block stk-30062fb\" data-block-id=\"30062fb\"><style>.stk-30062fb .stk-img-wrapper{width:80% !important;}<\/style><figure><span class=\"stk-img-wrapper stk-image--shape-stretch\"><img loading=\"lazy\" decoding=\"async\" class=\"stk-img wp-image-1159\" src=\"https:\/\/www.leloir.org.ar\/research\/wp-content\/uploads\/2026\/06\/Fil__Prat-Gay.png\" width=\"400\" height=\"400\" srcset=\"https:\/\/www.leloir.org.ar\/research\/wp-content\/uploads\/2026\/06\/Fil__Prat-Gay.png 400w, https:\/\/www.leloir.org.ar\/research\/wp-content\/uploads\/2026\/06\/Fil__Prat-Gay-300x300.png 300w, https:\/\/www.leloir.org.ar\/research\/wp-content\/uploads\/2026\/06\/Fil__Prat-Gay-150x150.png 150w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/span><\/figure><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-2075d5d\" data-block-id=\"2075d5d\"><style>.stk-2075d5d {margin-bottom:0px !important;}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #ffffff;\" class=\"stk-highlight\">Principal investigator<\/span><\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-b752a64\" id=\"gonzalo-prat-gay-ph-d\" data-block-id=\"b752a64\"><style>.stk-b752a64 .stk-block-heading__text{line-height:1.2em !important;}<\/style><h4 class=\"stk-block-heading__text\">Gonzalo Prat Gay, PhD<\/h4><\/div>\n\n\n\n<div class=\"wp-block-stackable-icon-label stk-block-icon-label stk-block stk-b51f5e0\" data-block-id=\"b51f5e0\"><style>.stk-b51f5e0 .stk-inner-blocks{gap:10px !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content\">\n<div class=\"wp-block-stackable-icon stk-block-icon has-text-align-left stk-block stk-e43d088\" data-block-id=\"e43d088\"><style>.stk-e43d088 .stk--svg-wrapper .stk--inner-svg svg:last-child{height:22px !important;width:22px !important;}.stk-e43d088 .stk--svg-wrapper .stk--inner-svg svg:last-child, .stk-e43d088 .stk--svg-wrapper .stk--inner-svg svg:last-child :is(g, path, rect, polygon, ellipse){fill:var(--theme-palette-color-5, #35b6b4) !important;}<\/style><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg style=\"height:0;width:0\"><defs><linearGradient id=\"linear-gradient-e43d088\" x1=\"0\" x2=\"100%\" y1=\"0\" y2=\"0\"><stop offset=\"0%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-e-43-d-088-color-1)\"><\/stop><stop offset=\"100%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-e-43-d-088-color-2)\"><\/stop><\/linearGradient><\/defs><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M64 112c-8.8 0-16 7.2-16 16v22.1L220.5 291.7c20.7 17 50.4 17 71.1 0L464 150.1V128c0-8.8-7.2-16-16-16H64zM48 212.2V384c0 8.8 7.2 16 16 16H448c8.8 0 16-7.2 16-16V212.2L322 328.8c-38.4 31.5-93.7 31.5-132 0L48 212.2zM0 128C0 92.7 28.7 64 64 64H448c35.3 0 64 28.7 64 64V384c0 35.3-28.7 64-64 64H64c-35.3 0-64-28.7-64-64V128z\"\/><\/svg><\/div><\/span><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-09109d8\" id=\"a-href-mailto-gpg-leloir-org-ar-gpg-leloir-org-ar-a\" data-block-id=\"09109d8\"><style>.stk-09109d8 .stk-block-heading__text{font-size:1.2rem !important;color:var(--theme-palette-color-5, #35b6b4) !important;}@media screen and (max-width:999px){.stk-09109d8 .stk-block-heading__text{font-size:1.2rem !important;}}<\/style><p class=\"stk-block-heading__text has-text-color\"><a href=\"mailto:gpg@leloir.org.ar\">gpg@leloir.org.ar<\/a><\/p><\/div>\n<\/div><\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-11caa78\" data-block-id=\"11caa78\"><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-11caa78-column\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-5123533\" data-v=\"4\" data-block-id=\"5123533\"><style>@media screen and (min-width:690px){.stk-5123533 {flex:var(--stk-flex-grow, 1) 1 calc(20% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-5123533-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-5123533-inner-blocks\">\n<div class=\"wp-block-stackable-icon stk-block-icon stk-block stk-6a46513\" data-block-id=\"6a46513\"><style>.stk-6a46513 .stk--svg-wrapper .stk--inner-svg svg:last-child{height:18px !important;width:18px !important;}.stk-6a46513 .stk--svg-wrapper .stk--inner-svg svg:last-child, .stk-6a46513 .stk--svg-wrapper .stk--inner-svg svg:last-child :is(g, path, rect, polygon, ellipse){fill:var(--theme-palette-color-3, #a7a04d) !important;}<\/style><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg style=\"height:0;width:0\"><defs><linearGradient id=\"linear-gradient-6a46513\" x1=\"0\" x2=\"100%\" y1=\"0\" y2=\"0\"><stop offset=\"0%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-6-a-46513-color-1)\"><\/stop><stop offset=\"100%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-6-a-46513-color-2)\"><\/stop><\/linearGradient><\/defs><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M336 352c97.2 0 176-78.8 176-176S433.2 0 336 0S160 78.8 160 176c0 18.7 2.9 36.8 8.3 53.7L7 391c-4.5 4.5-7 10.6-7 17v80c0 13.3 10.7 24 24 24h80c13.3 0 24-10.7 24-24V448h40c13.3 0 24-10.7 24-24V384h40c6.4 0 12.5-2.5 17-7l33.3-33.3c16.9 5.4 35 8.3 53.7 8.3zM376 96a40 40 0 1 1 0 80 40 40 0 1 1 0-80z\"\/><\/svg><\/div><\/span><\/div>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-566cc73\" data-v=\"4\" data-block-id=\"566cc73\"><style>@media screen and (min-width:690px){.stk-566cc73 {flex:var(--stk-flex-grow, 1) 1 calc(80% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-566cc73-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-566cc73-inner-blocks\">\n<ul style=\"padding-right:0;padding-left:0\" class=\"wp-block-list\">\n<li class=\"has-palette-color-3-color has-text-color has-link-color wp-elements-3b640a13091951095d8e482c84a346a9\" style=\"line-height:1.3\">Virus, cancer<br><\/li>\n\n\n\n<li class=\"has-palette-color-3-color has-text-color has-link-color wp-elements-f72828dd92a8a877cdd429472113a55a\" style=\"line-height:1.3\">protein biophysics<br><\/li>\n\n\n\n<li class=\"has-palette-color-3-color has-text-color has-link-color wp-elements-ca9fdf8b6c5340a1764b1d5e898251b4\" style=\"line-height:1.3\">biomolecular condensation<br><\/li>\n\n\n\n<li class=\"has-palette-color-3-color has-text-color has-link-color wp-elements-9fbe40ab31b079f9607c2e727206f8ef\" style=\"line-height:1.3\">p53<br><\/li>\n\n\n\n<li class=\"has-palette-color-3-color has-text-color has-link-color wp-elements-120dd5e1c445612f3ff726be5b88b23b\" style=\"line-height:1.3\">protein-RNA<br><\/li>\n\n\n\n<li class=\"has-palette-color-3-color has-text-color has-link-color wp-elements-1f7a63cc75671a90cb9b1559ae058ab0\" style=\"line-height:1.3\">antibodies<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n<\/div><\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Research area Biochemistry and structural biology<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_gspb_post_css":"#gspb_row-id-gsbp-2a38c9f{justify-content:space-between;margin-top:0;display:flex;flex-wrap:wrap;margin-bottom:0}#gspb_row-id-gsbp-2a38c9f>.gspb_row__content{display:flex;justify-content:space-between;margin:0 auto;width:100%;flex-wrap:wrap}div[id^=gspb_col-id]{box-sizing:border-box;position:relative;padding:var(--gs-row-column-padding, 15px min(3vw, 20px))}#gspb_col-id-gsbp-2fbf50f.gspb_row__col--9{width:calc(75% - 10px)}@media (max-width:991.98px){#gspb_col-id-gsbp-2fbf50f.gspb_row__col--9{width:calc(75% - 10px)}}@media (max-width:767.98px){#gspb_col-id-gsbp-2fbf50f.gspb_row__col--9{width:calc(75% - 10px)}}@media (max-width:575.98px){#gspb_col-id-gsbp-2fbf50f.gspb_row__col--9{width:100%}}#gspb_col-id-gsbp-6a5e99e.gspb_row__col--3{width:calc(25% - 10px)}@media 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