{"id":1300,"date":"2026-06-29T12:25:45","date_gmt":"2026-06-29T15:25:45","guid":{"rendered":"https:\/\/www.leloir.org.ar\/research\/?page_id=1300"},"modified":"2026-07-07T11:49:21","modified_gmt":"2026-07-07T14:49:21","slug":"structural-cell-biology","status":"publish","type":"page","link":"https:\/\/www.leloir.org.ar\/research\/structural-cell-biology\/","title":{"rendered":"structural cell biology"},"content":{"rendered":"\n<div class=\"wp-block-stackable-spacer stk-block-spacer stk--no-padding stk-block stk-66162b7\" id=\"strong-research-area-strong\" data-block-id=\"66162b7\"><style>.stk-66162b7 {height:20px !important;}<\/style><\/div>\n\n\n\n<div class=\"wp-block-stackable-columns alignfull stk-block-columns stk--hide-mobile stk-block stk-5e5bfe3\" data-block-id=\"5e5bfe3\"><style>.stk-5e5bfe3 {top:0px !important;left:0px !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-5e5bfe3-column alignfull\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-4ef4e82 stk-block-background\" data-v=\"4\" data-block-id=\"4ef4e82\"><style>.stk-4ef4e82-container{margin-top:var(--stk--preset--spacing--none, 0px) !important;margin-right:var(--stk--preset--spacing--none, 0px) !important;margin-bottom:var(--stk--preset--spacing--none, 0px) !important;margin-left:var(--stk--preset--spacing--none, 0px) !important;min-height:var(--stk--preset--block-height--none, 0px) !important;}.stk-4ef4e82 {align-self:center !important;background-color:var(--theme-palette-color-1, #164193) !important;border-top-right-radius:var(--stk--preset--border-radius--full, 9999px) !important;border-bottom-right-radius:var(--stk--preset--border-radius--full, 9999px) !important;border-bottom-left-radius:var(--stk--preset--border-radius--none, 0px) !important;overflow:hidden !important;min-height:var(--stk--preset--block-height--none, 0px) !important;align-items:center !important;max-width:525px !important;min-width:auto !important;padding-top:var(--stk--preset--spacing--none, 0px) !important;padding-bottom:var(--stk--preset--spacing--none, 0px) !important;padding-left:60px !important;margin-top:var(--stk--preset--spacing--none, 0px) !important;margin-left:0px !important;display:flex !important;}.stk-4ef4e82:before{background-color:var(--theme-palette-color-1, #164193) !important;}@media screen and (min-width:690px){.stk-4ef4e82 {flex:var(--stk-flex-grow, 1) 1 calc(56% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-4ef4e82-container stk--no-background stk--no-padding\"><div class=\"has-text-align-left stk--block-horizontal-flex stk-block-content stk-inner-blocks stk-4ef4e82-inner-blocks\">\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-5ee0490\" data-block-id=\"5ee0490\"><style>.stk-5ee0490 {padding-top:var(--stk--preset--spacing--none, 0px) !important;padding-right:0px !important;padding-bottom:var(--stk--preset--spacing--none, 0px) !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-5ee0490-column\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-c7a375f\" data-v=\"4\" data-block-id=\"c7a375f\"><style>.stk-c7a375f {padding-left:var(--stk--preset--spacing--none, 0px) !important;margin-right:var(--stk--preset--spacing--none, 0px) !important;margin-left:var(--stk--preset--spacing--none, 0px) !important;}.stk-c7a375f-container{padding-left:var(--stk--preset--spacing--none, 0px) !important;}@media screen and (min-width:690px){.stk-c7a375f {flex:var(--stk-flex-grow, 1) 1 calc(81.1% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-c7a375f-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-c7a375f-inner-blocks\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-dd4c5d4\" id=\"strong-research-area-strong\" data-block-id=\"dd4c5d4\"><style>.stk-dd4c5d4 {margin-bottom:0px !important;}.stk-dd4c5d4 .stk-block-heading__text{color:var(--theme-palette-color-3, #a7a04d) !important;}<\/style><h6 class=\"stk-block-heading__text has-text-color\"><strong>Research area<\/strong><\/h6><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-9644f8c\" id=\"strong-biochemistry-and-structural-biology-strong\" data-block-id=\"9644f8c\"><style>.stk-9644f8c {align-items:flex-start !important;padding-top:var(--stk--preset--spacing--none, 0px) !important;padding-bottom:var(--stk--preset--spacing--none, 0px) !important;margin-top:var(--stk--preset--spacing--none, 0px) !important;margin-bottom:var(--stk--preset--spacing--none, 0px) !important;margin-left:var(--stk--preset--spacing--none, 0px) !important;display:flex !important;}<\/style><h5 class=\"stk-block-heading__text\"><strong>Biochemistry and structural biology<\/strong><\/h5><\/div>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-09bc26b\" data-v=\"4\" data-block-id=\"09bc26b\"><style>.stk-09bc26b {align-self:center !important;padding-top:var(--stk--preset--spacing--none, 0px) !important;padding-right:var(--stk--preset--spacing--none, 0px) !important;padding-bottom:var(--stk--preset--spacing--none, 0px) !important;padding-left:var(--stk--preset--spacing--none, 0px) !important;margin-right:var(--stk--preset--spacing--none, 0px) !important;}.stk-09bc26b-inner-blocks{align-items:center !important;}@media screen and (min-width:690px){.stk-09bc26b {flex:var(--stk-flex-grow, 1) 1 calc(18.9% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-09bc26b-container stk--no-background stk--no-padding\"><div class=\"stk--block-horizontal-flex stk--column-flex stk-block-content stk-inner-blocks stk-09bc26b-inner-blocks\">\n<div class=\"wp-block-stackable-image stk-block-image stk-block stk-f3f39b4\" data-block-id=\"f3f39b4\"><style>.stk-f3f39b4 .stk-img-wrapper{width:100% !important;}<\/style><figure><span class=\"stk-img-wrapper stk-image--shape-stretch\"><img loading=\"lazy\" decoding=\"async\" class=\"stk-img wp-image-1063\" src=\"https:\/\/www.leloir.org.ar\/research\/wp-content\/uploads\/2026\/06\/Biochemistry.png\" width=\"100\" height=\"100\"\/><\/span><\/figure><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-091b9de\" data-v=\"4\" data-block-id=\"091b9de\"><style>@media screen and (min-width:690px){.stk-091b9de {flex:var(--stk-flex-grow, 1) 1 calc(44% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-091b9de-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-091b9de-inner-blocks\"><\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-greenshift-blocks-container alignfull gspb_container gspb_container-gsbp-c15c419\" id=\"gspb_container-id-gsbp-c15c419\">\n<div class=\"wp-block-greenshift-blocks-row gspb_row gspb_row-id-gsbp-18a8bbc\" id=\"gspb_row-id-gsbp-18a8bbc\"><div class=\"gspb_row__content\"> \n<div class=\"wp-block-greenshift-blocks-row-column gspb_row__col--6 gspb_row__col--xs-9 gspb_col-id-gsbp-1de9e8b\" id=\"gspb_col-id-gsbp-1de9e8b\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-fe81fce\" id=\"strong-research-area-strong\" data-block-id=\"fe81fce\"><style>.stk-fe81fce .stk-block-heading__text{color:var(--theme-palette-color-3, #a7a04d) !important;}@media screen and (max-width:689px){.stk-fe81fce {padding-bottom:0px !important;margin-bottom:0px !important;}}<\/style><h6 class=\"stk-block-heading__text has-text-color\"><strong>Research area<\/strong><\/h6><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-f5d6339\" id=\"strong-research-area-strong\" data-block-id=\"f5d6339\"><style>@media screen and (max-width:689px){.stk-f5d6339 {align-items:flex-start !important;padding-top:0px !important;padding-right:0px !important;padding-bottom:0px !important;padding-left:0px !important;margin-bottom:0px !important;display:flex !important;}}<\/style><h5 class=\"stk-block-heading__text has-text-align-left-mobile\"><strong><strong>Biochemistry and structural biology<\/strong><\/strong><\/h5><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-greenshift-blocks-row-column gspb_row__col--6 gspb_row__col--xs-3 gspb_col-id-gsbp-643144c\" id=\"gspb_col-id-gsbp-643144c\">\n<div class=\"wp-block-stackable-image stk-block-image stk-block stk-aaae08c\" data-block-id=\"aaae08c\"><style>@media screen and (max-width:689px){.stk-aaae08c .stk-img-wrapper{width:70% !important;}}<\/style><figure><span class=\"stk-img-wrapper stk-image--shape-stretch\"><img loading=\"lazy\" decoding=\"async\" class=\"stk-img wp-image-1063\" src=\"https:\/\/www.leloir.org.ar\/research\/wp-content\/uploads\/2026\/06\/Biochemistry.png\" width=\"100\" height=\"100\"\/><\/span><\/figure><\/div>\n<\/div>\n <\/div><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-stackable-spacer stk-block-spacer stk--no-padding stk-block stk-af0c2a1\" id=\"strong-research-area-strong\" data-block-id=\"af0c2a1\"><style>.stk-af0c2a1 {height:30px !important;}<\/style><\/div>\n\n\n\n<div class=\"wp-block-greenshift-blocks-row alignwide gspb_row gspb_row-id-gsbp-2a38c9f gspb_row--gutter-20\" id=\"gspb_row-id-gsbp-2a38c9f\">\n<div class=\"wp-block-greenshift-blocks-row-column gspb_row__col--9 gspb_col-id-gsbp-2fbf50f\" id=\"gspb_col-id-gsbp-2fbf50f\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-133764c\" id=\"structural-cell-biology\" data-block-id=\"133764c\"><style>.stk-133764c {margin-bottom:40px !important;}.stk-133764c .stk-block-heading__text{color:var(--theme-palette-color-3, #a7a04d) !important;}<\/style><h2 class=\"stk-block-heading__text has-text-color\">STRUCTURAL CELL BIOLOGY<\/h2><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-28e8a58\" id=\"strong-research-strong\" data-block-id=\"28e8a58\"><style>.stk-28e8a58 .stk-block-heading__text{color:var(--theme-palette-color-1, #164193) !important;}<\/style><h3 class=\"stk-block-heading__text has-text-color\"><strong>Research<\/strong><\/h3><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-b332380\" data-block-id=\"b332380\"><p class=\"stk-block-text__text\">The final step in the protein biogenesis pathway is the acquisition of the native, biologically active conformation. Failures in this complex process or in the maintenance of the native conformation can trigger the formation of toxic protein aggregates, which are the underlying cause of some of the most devastating human diseases, such as Parkinson&#8217;s disease, Alzheimer&#8217;s disease, and Creutzfeldt-Jakob disease. Our research focuses on the molecular mechanisms that ensure the efficiency of this process in the secretory pathway of eukaryotic cells. Approximately one-third of the eukaryotic proteome belongs to the secretory pathway. These proteins enter the endoplasmic reticulum (ER) or are inserted into its membrane during their synthesis. In the ER, several molecular chaperones and folding-facilitating enzymes assist in the folding process of thousands of different proteins. In addition, most of these proteins undergo post-translational chemical modifications, with the addition of N-glycans being the most common and drastic. Frequently, this modification is necessary to acquire a correct fold and\/or to properly target these proteins to their final destination. Our aim is to understand how these intricate proteostasis systems coordinate their activities to ensure the efficiency of the folding process in the cells. To this end, we employ diverse molecular, cellular, biophysical, and bioinformatics approaches, combining experiments performed in vivo, in vitro, and in silico.<\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-a654e8d\" id=\"strong-skills-amp-tools-strong\" data-block-id=\"a654e8d\"><style>.stk-a654e8d .stk-block-heading__text{color:var(--theme-palette-color-1, #164193) !important;}<\/style><h3 class=\"stk-block-heading__text has-text-color\"><strong>Skills &amp; tools<\/strong><\/h3><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-260d7c4\" data-block-id=\"260d7c4\"><p class=\"stk-block-text__text\">Our laboratory utilizes a broad spectrum of techniques. On one hand, we express and purify proteins for their biophysical characterization in vitro. On the other hand, we study the biogenesis of these proteins in cell cultures, following their folding maturation in real time and their N-glycosylation status. Finally, we integrate this information using a combination of data analysis and systems biology. This approach allows us to integrate different sources of information into coherent models that explain and predict the behavior of these highly complex systems. We employ a wide range of experimental techniques, such as gene cloning and site-directed mutagenesis, fluorescence and circular dichroism spectroscopies, calorimetry, cell culture, fluorescence confocal microscopy, and Western blotting.<\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-5168ba6\" id=\"strong-collaboration-interests-strong\" data-block-id=\"5168ba6\"><style>.stk-5168ba6 {margin-bottom:3px !important;}.stk-5168ba6 .stk-block-heading__text{color:var(--theme-palette-color-1, #164193) !important;}<\/style><h3 class=\"stk-block-heading__text has-text-color\"><strong>Collaboration interests<\/strong><\/h3><\/div>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Protein biophysics<\/li>\n\n\n\n<li>Recombinant protein expression<\/li>\n\n\n\n<li>Systems biology and data analysis<\/li>\n\n\n\n<li>Fluorescence microscopy and image analysis<\/li>\n<\/ul>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-341a9f4\" id=\"strong-selected-publications-strong\" data-block-id=\"341a9f4\"><style>.stk-341a9f4 {margin-bottom:3px !important;}.stk-341a9f4 .stk-block-heading__text{color:var(--theme-palette-color-1, #164193) !important;}<\/style><h3 class=\"stk-block-heading__text has-text-color\"><strong>Selected publications<\/strong><\/h3><\/div>\n\n\n\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-193dbfa\" data-block-id=\"193dbfa\"><style>.stk-193dbfa {padding-left:0px !important;margin-bottom:var(--stk--preset--spacing--none, 0px) !important;}.stk-193dbfa-column{--stk-column-gap:var(--stk--preset--spacing--20, 0.44rem) !important;justify-content:flex-start !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-193dbfa-column stk--flex\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-f6f2387\" data-v=\"4\" data-block-id=\"f6f2387\"><style>.stk-f6f2387 {min-height:var(--stk--preset--block-height--none, 0px) !important;max-width:1500px !important;min-width:auto !important;padding-left:var(--stk--preset--spacing--none, 0px) !important;margin-right:auto !important;margin-left:var(--stk--preset--spacing--none, 0px) !important;}@media screen and (min-width:690px){.stk-f6f2387 {flex:var(--stk-flex-grow, 1) 1 calc(82% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-f6f2387-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-f6f2387-inner-blocks\">\n<ul class=\"wp-block-list\">\n<li style=\"margin-left:0\">COUTO, Paula M., et al. Acceptors stability modulates the efficiency of post-translational protein N-glycosylation. FASEB journal: official publication of the Federation of American Societies for Experimental Biology, 2024, vol. 38, no 13, p. e23782.<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-5a33621\" data-v=\"4\" data-block-id=\"5a33621\"><style>@media screen and (min-width:690px){.stk-5a33621 {flex:var(--stk-flex-grow, 1) 1 calc(18% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-5a33621-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-5a33621-inner-blocks\">\n<div class=\"wp-block-stackable-button-group stk-block-button-group stk-block stk-b873c6a\" data-block-id=\"b873c6a\"><div class=\"stk-row stk-inner-blocks stk-block-content stk-button-group\">\n<div class=\"wp-block-stackable-icon-button stk-block-icon-button stk-block stk-776b4f5\" data-block-id=\"776b4f5\"><style>.stk-776b4f5 .stk-button{background:var(--theme-palette-color-1, #164193) !important;}.stk-776b4f5 .stk-button:hover{background:var(--theme-palette-color-2, #312a74) !important;opacity:1 !important;}<\/style><a class=\"stk-link stk-button stk--hover-effect-darken\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC11307252\/\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 640 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M579.8 267.7c56.5-56.5 56.5-148 0-204.5c-50-50-128.8-56.5-186.3-15.4l-1.6 1.1c-14.4 10.3-17.7 30.3-7.4 44.6s30.3 17.7 44.6 7.4l1.6-1.1c32.1-22.9 76-19.3 103.8 8.6c31.5 31.5 31.5 82.5 0 114L422.3 334.8c-31.5 31.5-82.5 31.5-114 0c-27.9-27.9-31.5-71.8-8.6-103.8l1.1-1.6c10.3-14.4 6.9-34.4-7.4-44.6s-34.4-6.9-44.6 7.4l-1.1 1.6C206.5 251.2 213 330 263 380c56.5 56.5 148 56.5 204.5 0L579.8 267.7zM60.2 244.3c-56.5 56.5-56.5 148 0 204.5c50 50 128.8 56.5 186.3 15.4l1.6-1.1c14.4-10.3 17.7-30.3 7.4-44.6s-30.3-17.7-44.6-7.4l-1.6 1.1c-32.1 22.9-76 19.3-103.8-8.6C74 372 74 321 105.5 289.5L217.7 177.2c31.5-31.5 82.5-31.5 114 0c27.9 27.9 31.5 71.8 8.6 103.9l-1.1 1.6c-10.3 14.4-6.9 34.4 7.4 44.6s34.4 6.9 44.6-7.4l1.1-1.6C433.5 260.8 427 182 377 132c-56.5-56.5-148-56.5-204.5 0L60.2 244.3z\"\/><\/svg><\/div><\/span><\/a><\/div>\n<\/div><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-divider alignfull stk-block-divider stk--hide-desktop has-text-align-center stk-block stk-a076026\" data-block-id=\"a076026\"><style>.stk-a076026 hr.stk-block-divider__hr{background:#abb8c3 !important;}@media screen and (max-width:689px){.stk-a076026 {align-items:center !important;margin-bottom:0px !important;display:flex !important;}}<\/style><hr class=\"stk-block-divider__hr\"\/><\/div>\n\n\n\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-5a54113\" data-block-id=\"5a54113\"><style>.stk-5a54113 {padding-left:0px !important;margin-bottom:var(--stk--preset--spacing--none, 0px) !important;}.stk-5a54113-column{--stk-column-gap:var(--stk--preset--spacing--20, 0.44rem) !important;justify-content:flex-start !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-5a54113-column stk--flex\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-4e5e1c5\" data-v=\"4\" data-block-id=\"4e5e1c5\"><style>.stk-4e5e1c5 {min-height:var(--stk--preset--block-height--none, 0px) !important;max-width:1500px !important;min-width:auto !important;padding-left:var(--stk--preset--spacing--none, 0px) !important;margin-right:auto !important;margin-left:var(--stk--preset--spacing--none, 0px) !important;}@media screen and (min-width:690px){.stk-4e5e1c5 {flex:var(--stk-flex-grow, 1) 1 calc(82% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-4e5e1c5-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-4e5e1c5-inner-blocks\">\n<ul class=\"wp-block-list\">\n<li style=\"margin-left:0\">MEDUS, M\u00e1ximo Lopez, et al. N-glycosylation triggers a dual selection pressure in eukaryotic secretory proteins. Scientific reports, 2017, vol. 7, no 1, p. 8788.<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-ef8479e\" data-v=\"4\" data-block-id=\"ef8479e\"><style>@media screen and (min-width:690px){.stk-ef8479e {flex:var(--stk-flex-grow, 1) 1 calc(18% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-ef8479e-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-ef8479e-inner-blocks\">\n<div class=\"wp-block-stackable-button-group stk-block-button-group stk-block stk-98399e6\" data-block-id=\"98399e6\"><div class=\"stk-row stk-inner-blocks stk-block-content stk-button-group\">\n<div class=\"wp-block-stackable-icon-button stk-block-icon-button stk-block stk-edb2ba1\" data-block-id=\"edb2ba1\"><style>.stk-edb2ba1 .stk-button{background:var(--theme-palette-color-1, #164193) !important;}.stk-edb2ba1 .stk-button:hover{background:var(--theme-palette-color-2, #312a74) !important;opacity:1 !important;}<\/style><a class=\"stk-link stk-button stk--hover-effect-darken\" href=\"https:\/\/www.nature.com\/articles\/s41598-017-09173-6\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 640 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M579.8 267.7c56.5-56.5 56.5-148 0-204.5c-50-50-128.8-56.5-186.3-15.4l-1.6 1.1c-14.4 10.3-17.7 30.3-7.4 44.6s30.3 17.7 44.6 7.4l1.6-1.1c32.1-22.9 76-19.3 103.8 8.6c31.5 31.5 31.5 82.5 0 114L422.3 334.8c-31.5 31.5-82.5 31.5-114 0c-27.9-27.9-31.5-71.8-8.6-103.8l1.1-1.6c10.3-14.4 6.9-34.4-7.4-44.6s-34.4-6.9-44.6 7.4l-1.1 1.6C206.5 251.2 213 330 263 380c56.5 56.5 148 56.5 204.5 0L579.8 267.7zM60.2 244.3c-56.5 56.5-56.5 148 0 204.5c50 50 128.8 56.5 186.3 15.4l1.6-1.1c14.4-10.3 17.7-30.3 7.4-44.6s-30.3-17.7-44.6-7.4l-1.6 1.1c-32.1 22.9-76 19.3-103.8-8.6C74 372 74 321 105.5 289.5L217.7 177.2c31.5-31.5 82.5-31.5 114 0c27.9 27.9 31.5 71.8 8.6 103.9l-1.1 1.6c-10.3 14.4-6.9 34.4 7.4 44.6s34.4 6.9 44.6-7.4l1.1-1.6C433.5 260.8 427 182 377 132c-56.5-56.5-148-56.5-204.5 0L60.2 244.3z\"\/><\/svg><\/div><\/span><\/a><\/div>\n<\/div><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-divider alignfull stk-block-divider stk--hide-desktop has-text-align-center stk-block stk-5749c12\" data-block-id=\"5749c12\"><style>.stk-5749c12 hr.stk-block-divider__hr{background:#abb8c3 !important;}@media screen and (max-width:689px){.stk-5749c12 {align-items:center !important;margin-bottom:0px !important;display:flex !important;}}<\/style><hr class=\"stk-block-divider__hr\"\/><\/div>\n\n\n\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-2cc98fc\" data-block-id=\"2cc98fc\"><style>.stk-2cc98fc {padding-left:0px !important;margin-bottom:var(--stk--preset--spacing--none, 0px) !important;}.stk-2cc98fc-column{--stk-column-gap:var(--stk--preset--spacing--20, 0.44rem) !important;justify-content:flex-start !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-2cc98fc-column stk--flex\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-2d73e22\" data-v=\"4\" data-block-id=\"2d73e22\"><style>.stk-2d73e22 {min-height:var(--stk--preset--block-height--none, 0px) !important;max-width:1500px !important;min-width:auto !important;padding-left:var(--stk--preset--spacing--none, 0px) !important;margin-right:auto !important;margin-left:var(--stk--preset--spacing--none, 0px) !important;}@media screen and (min-width:690px){.stk-2d73e22 {flex:var(--stk-flex-grow, 1) 1 calc(82% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-2d73e22-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-2d73e22-inner-blocks\">\n<ul class=\"wp-block-list\">\n<li style=\"margin-left:0\">PAGANO, Rodrigo S., et al. Protein fibrillation lag times during kinetic inhibition. Biophysical journal, 2014, vol. 107, no 3, p. 711-720.<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-7f13117\" data-v=\"4\" data-block-id=\"7f13117\"><style>@media screen and (min-width:690px){.stk-7f13117 {flex:var(--stk-flex-grow, 1) 1 calc(18% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-7f13117-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-7f13117-inner-blocks\">\n<div class=\"wp-block-stackable-button-group stk-block-button-group stk-block stk-d13ba5c\" data-block-id=\"d13ba5c\"><div class=\"stk-row stk-inner-blocks stk-block-content stk-button-group\">\n<div class=\"wp-block-stackable-icon-button stk-block-icon-button stk-block stk-043b817\" data-block-id=\"043b817\"><style>.stk-043b817 .stk-button{background:var(--theme-palette-color-1, #164193) !important;}.stk-043b817 .stk-button:hover{background:var(--theme-palette-color-2, #312a74) !important;opacity:1 !important;}<\/style><a class=\"stk-link stk-button stk--hover-effect-darken\" href=\"https:\/\/www.cell.com\/biophysj\/fulltext\/S0006-3495(14)00672-9\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 640 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M579.8 267.7c56.5-56.5 56.5-148 0-204.5c-50-50-128.8-56.5-186.3-15.4l-1.6 1.1c-14.4 10.3-17.7 30.3-7.4 44.6s30.3 17.7 44.6 7.4l1.6-1.1c32.1-22.9 76-19.3 103.8 8.6c31.5 31.5 31.5 82.5 0 114L422.3 334.8c-31.5 31.5-82.5 31.5-114 0c-27.9-27.9-31.5-71.8-8.6-103.8l1.1-1.6c10.3-14.4 6.9-34.4-7.4-44.6s-34.4-6.9-44.6 7.4l-1.1 1.6C206.5 251.2 213 330 263 380c56.5 56.5 148 56.5 204.5 0L579.8 267.7zM60.2 244.3c-56.5 56.5-56.5 148 0 204.5c50 50 128.8 56.5 186.3 15.4l1.6-1.1c14.4-10.3 17.7-30.3 7.4-44.6s-30.3-17.7-44.6-7.4l-1.6 1.1c-32.1 22.9-76 19.3-103.8-8.6C74 372 74 321 105.5 289.5L217.7 177.2c31.5-31.5 82.5-31.5 114 0c27.9 27.9 31.5 71.8 8.6 103.9l-1.1 1.6c-10.3 14.4-6.9 34.4 7.4 44.6s34.4 6.9 44.6-7.4l1.1-1.6C433.5 260.8 427 182 377 132c-56.5-56.5-148-56.5-204.5 0L60.2 244.3z\"\/><\/svg><\/div><\/span><\/a><\/div>\n<\/div><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-divider alignfull stk-block-divider stk--hide-desktop has-text-align-center stk-block stk-94d5b9d\" data-block-id=\"94d5b9d\"><style>.stk-94d5b9d hr.stk-block-divider__hr{background:#abb8c3 !important;}@media screen and (max-width:689px){.stk-94d5b9d {align-items:center !important;margin-bottom:0px !important;display:flex !important;}}<\/style><hr class=\"stk-block-divider__hr\"\/><\/div>\n\n\n\n<div class=\"wp-block-stackable-spacer stk-block-spacer stk--no-padding stk-block stk-9f3d337\" data-block-id=\"9f3d337\"><style>.stk-9f3d337 {height:30px !important;}<\/style><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-greenshift-blocks-row-column gspb_row__col--3 gspb_col-id-gsbp-6a5e99e\" id=\"gspb_col-id-gsbp-6a5e99e\">\n<div class=\"wp-block-stackable-image stk-block-image stk-block stk-30062fb\" data-block-id=\"30062fb\"><style>.stk-30062fb .stk-img-wrapper{width:80% !important;}<\/style><figure><span class=\"stk-img-wrapper stk-image--shape-stretch\"><img loading=\"lazy\" decoding=\"async\" class=\"stk-img wp-image-1142\" src=\"https:\/\/www.leloir.org.ar\/research\/wp-content\/uploads\/2026\/06\/Fil__Caramelo.png\" width=\"400\" height=\"400\" srcset=\"https:\/\/www.leloir.org.ar\/research\/wp-content\/uploads\/2026\/06\/Fil__Caramelo.png 400w, https:\/\/www.leloir.org.ar\/research\/wp-content\/uploads\/2026\/06\/Fil__Caramelo-300x300.png 300w, https:\/\/www.leloir.org.ar\/research\/wp-content\/uploads\/2026\/06\/Fil__Caramelo-150x150.png 150w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/span><\/figure><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-2075d5d\" data-block-id=\"2075d5d\"><style>.stk-2075d5d {margin-bottom:0px !important;}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #ffffff;\" class=\"stk-highlight\">Principal investigator<\/span><\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-b752a64\" id=\"julio-caramelo-ph-d\" data-block-id=\"b752a64\"><style>.stk-b752a64 .stk-block-heading__text{line-height:1.2em !important;}<\/style><h4 class=\"stk-block-heading__text\">Julio Caramelo, PhD<\/h4><\/div>\n\n\n\n<div class=\"wp-block-stackable-icon-label stk-block-icon-label stk-block stk-b51f5e0\" data-block-id=\"b51f5e0\"><style>.stk-b51f5e0 .stk-inner-blocks{gap:10px !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content\">\n<div class=\"wp-block-stackable-icon stk-block-icon has-text-align-left stk-block stk-e43d088\" data-block-id=\"e43d088\"><style>.stk-e43d088 .stk--svg-wrapper .stk--inner-svg svg:last-child{height:22px !important;width:22px !important;}.stk-e43d088 .stk--svg-wrapper .stk--inner-svg svg:last-child, .stk-e43d088 .stk--svg-wrapper .stk--inner-svg svg:last-child :is(g, path, rect, polygon, ellipse){fill:var(--theme-palette-color-5, #35b6b4) !important;}<\/style><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg style=\"height:0;width:0\"><defs><linearGradient id=\"linear-gradient-e43d088\" x1=\"0\" x2=\"100%\" y1=\"0\" y2=\"0\"><stop offset=\"0%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-e-43-d-088-color-1)\"><\/stop><stop offset=\"100%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-e-43-d-088-color-2)\"><\/stop><\/linearGradient><\/defs><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M64 112c-8.8 0-16 7.2-16 16v22.1L220.5 291.7c20.7 17 50.4 17 71.1 0L464 150.1V128c0-8.8-7.2-16-16-16H64zM48 212.2V384c0 8.8 7.2 16 16 16H448c8.8 0 16-7.2 16-16V212.2L322 328.8c-38.4 31.5-93.7 31.5-132 0L48 212.2zM0 128C0 92.7 28.7 64 64 64H448c35.3 0 64 28.7 64 64V384c0 35.3-28.7 64-64 64H64c-35.3 0-64-28.7-64-64V128z\"\/><\/svg><\/div><\/span><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-09109d8\" id=\"a-href-mailto-jcaramelo-leloir-org-ar-jcaramelo-leloir-org-ar-a\" data-block-id=\"09109d8\"><style>.stk-09109d8 .stk-block-heading__text{font-size:1.2rem !important;color:var(--theme-palette-color-5, #35b6b4) !important;}@media screen and (max-width:999px){.stk-09109d8 .stk-block-heading__text{font-size:1.2rem !important;}}<\/style><p class=\"stk-block-heading__text has-text-color\"><a href=\"mailto:jcaramelo@leloir.org.ar\">jcaramelo@leloir.org.ar<\/a><\/p><\/div>\n<\/div><\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-11caa78\" data-block-id=\"11caa78\"><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-11caa78-column\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-5123533\" data-v=\"4\" data-block-id=\"5123533\"><style>@media screen and (min-width:690px){.stk-5123533 {flex:var(--stk-flex-grow, 1) 1 calc(20% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-5123533-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-5123533-inner-blocks\">\n<div class=\"wp-block-stackable-icon stk-block-icon stk-block stk-6a46513\" data-block-id=\"6a46513\"><style>.stk-6a46513 .stk--svg-wrapper .stk--inner-svg svg:last-child{height:18px !important;width:18px !important;}.stk-6a46513 .stk--svg-wrapper .stk--inner-svg svg:last-child, .stk-6a46513 .stk--svg-wrapper .stk--inner-svg svg:last-child :is(g, path, rect, polygon, ellipse){fill:var(--theme-palette-color-3, #a7a04d) !important;}<\/style><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg style=\"height:0;width:0\"><defs><linearGradient id=\"linear-gradient-6a46513\" x1=\"0\" x2=\"100%\" y1=\"0\" y2=\"0\"><stop offset=\"0%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-6-a-46513-color-1)\"><\/stop><stop offset=\"100%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-6-a-46513-color-2)\"><\/stop><\/linearGradient><\/defs><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M336 352c97.2 0 176-78.8 176-176S433.2 0 336 0S160 78.8 160 176c0 18.7 2.9 36.8 8.3 53.7L7 391c-4.5 4.5-7 10.6-7 17v80c0 13.3 10.7 24 24 24h80c13.3 0 24-10.7 24-24V448h40c13.3 0 24-10.7 24-24V384h40c6.4 0 12.5-2.5 17-7l33.3-33.3c16.9 5.4 35 8.3 53.7 8.3zM376 96a40 40 0 1 1 0 80 40 40 0 1 1 0-80z\"\/><\/svg><\/div><\/span><\/div>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-566cc73\" data-v=\"4\" data-block-id=\"566cc73\"><style>@media screen and (min-width:690px){.stk-566cc73 {flex:var(--stk-flex-grow, 1) 1 calc(80% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-566cc73-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-566cc73-inner-blocks\">\n<ul style=\"padding-right:0;padding-left:0\" class=\"wp-block-list\">\n<li class=\"has-palette-color-3-color has-text-color has-link-color wp-elements-a6763776ea04aa356cb0aeb90b9376a1\" style=\"line-height:1.3\">protein folding<br><\/li>\n\n\n\n<li class=\"has-palette-color-3-color has-text-color has-link-color wp-elements-45c0cad6f4dbd382725d1de01702d3af\" style=\"line-height:1.3\">endoplasmic reticulum<br><\/li>\n\n\n\n<li class=\"has-palette-color-3-color has-text-color has-link-color wp-elements-35d7fb9c877a5099e20fedc674168ee0\" style=\"line-height:1.3\">N-glycosylation<br><\/li>\n\n\n\n<li class=\"has-palette-color-3-color has-text-color has-link-color wp-elements-e18967c8039df6e699a9836ac01013e2\" style=\"line-height:1.3\">proteostasis<br><\/li>\n\n\n\n<li class=\"has-palette-color-3-color has-text-color has-link-color wp-elements-d13aad37ce8e381efc2b56d7670ef23e\" style=\"line-height:1.3\">neurodegenerative diseases<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n<\/div><\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Research area Biochemistry and structural biology<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_gspb_post_css":"#gspb_row-id-gsbp-2a38c9f{justify-content:space-between;margin-top:0;display:flex;flex-wrap:wrap;margin-bottom:0}#gspb_row-id-gsbp-2a38c9f>.gspb_row__content{display:flex;justify-content:space-between;margin:0 auto;width:100%;flex-wrap:wrap}div[id^=gspb_col-id]{box-sizing:border-box;position:relative;padding:var(--gs-row-column-padding, 15px min(3vw, 20px))}#gspb_col-id-gsbp-2fbf50f.gspb_row__col--9{width:calc(75% - 10px)}@media (max-width:991.98px){#gspb_col-id-gsbp-2fbf50f.gspb_row__col--9{width:calc(75% - 10px)}}@media (max-width:767.98px){#gspb_col-id-gsbp-2fbf50f.gspb_row__col--9{width:calc(75% - 10px)}}@media (max-width:575.98px){#gspb_col-id-gsbp-2fbf50f.gspb_row__col--9{width:100%}}#gspb_col-id-gsbp-6a5e99e.gspb_row__col--3{width:calc(25% - 10px)}@media 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