{"id":1298,"date":"2026-06-29T12:14:08","date_gmt":"2026-06-29T15:14:08","guid":{"rendered":"https:\/\/www.leloir.org.ar\/research\/?page_id=1298"},"modified":"2026-08-06T15:15:02","modified_gmt":"2026-08-06T18:15:02","slug":"molecular-and-cellular-therapy","status":"publish","type":"page","link":"https:\/\/www.leloir.org.ar\/research\/molecular-and-cellular-therapy\/","title":{"rendered":"molecular and cellular  therapy"},"content":{"rendered":"\n<div class=\"wp-block-stackable-spacer stk-block-spacer stk--no-padding stk-block stk-66162b7\" id=\"strong-research-area-strong\" data-block-id=\"66162b7\"><style>.stk-66162b7 {height:20px !important;}<\/style><\/div>\n\n\n\n<div class=\"wp-block-greenshift-blocks-row alignfull gspb_row gspb_row-id-gsbp-5a0b21f\" id=\"gspb_row-id-gsbp-5a0b21f\"><div class=\"gspb_row__content\"> \n<div class=\"wp-block-greenshift-blocks-row-column gspb_row__col--4 gspb_row__col--xs-12 gspb_col-id-gsbp-184ece8\" id=\"gspb_col-id-gsbp-184ece8\">\n<h6 id=\"gspb_heading-id-gsbp-6cea568\" class=\"gspb_heading gspb_heading-id-gsbp-6cea568 \"><strong>Research area<\/strong><\/h6>\n\n\n\n<h5 id=\"gspb_heading-id-gsbp-5187666\" class=\"gspb_heading gspb_heading-id-gsbp-5187666 \"><strong>Cancer<\/strong><br><strong>Microbiology and infectious diseases<\/strong><\/h5>\n<\/div>\n\n\n\n<div class=\"wp-block-greenshift-blocks-row-column gspb_row__col--8 gspb_row__col--xs-12 gspb_col-id-gsbp-0b7cdeb\" id=\"gspb_col-id-gsbp-0b7cdeb\">\n<div class=\"wp-block-greenshift-blocks-container gspb_container gspb_container-gsbp-3fa2f65\" id=\"gspb_container-id-gsbp-3fa2f65\">\n<div class=\"wp-block-greenshift-blocks-iconbox gspb_iconBox gspb_iconBox-id-gsbp-c5db4cd\" id=\"gspb_iconBox-id-gsbp-c5db4cd\"><div class=\"gspb_iconBox__wrapper\" style=\"display:inline-flex\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" style=\"width:5rem;height:5rem;margin:10px\" id=\"a\" dataname=\"Capa 1\" viewBox=\"0 0 75 75\">  <path 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d=\"M45.68,26.84c.29,0,.58-.14.76-.4l3.26-4.66c.3-.42.19-1-.23-1.3-.42-.3-1.01-.19-1.3.23l-3.26,4.66c-.3.42-.19,1,.23,1.3.16.11.35.17.53.17\" fill=\"#a7a04d\"><\/path>\n  <path d=\"M23.89,36.22c-.45-.25-1.02-.09-1.27.36l-3.42,6.14c-.25.45-.09,1.02.36,1.27.14.08.3.12.45.12.33,0,.64-.17.82-.48l3.42-6.14c.25-.45.09-1.02-.36-1.27\" fill=\"#a7a04d\"><\/path>\n  <path d=\"M54.19,29.98l-6.52-1.09c-.5-.08-.99.26-1.07.77-.08.51.26.99.77,1.07l6.53,1.09c.05,0,.1.01.15.01.45,0,.84-.32.92-.78.08-.51-.26-.99-.77-1.07\" fill=\"#a7a04d\"><\/path>\n  <path d=\"M32.73,51.85l-6.37-1.32c-.51-.1-1,.22-1.1.72-.1.51.22,1,.72,1.1l6.37,1.32c.06.01.13.02.19.02.43,0,.82-.3.91-.74.1-.5-.22-1-.72-1.1\" fill=\"#a7a04d\"><\/path>\n  <path d=\"M56.91,35.42c-.08-.51-.56-.85-1.07-.77-.51.08-.85.56-.77,1.07l1.01,6.21c.07.46.47.78.92.78.05,0,.1,0,.15-.01.51-.08.85-.56.77-1.07l-1.01-6.21Z\" fill=\"#a7a04d\"><\/path>\n  <path d=\"M22.9,25.12c.11,0,.22-.02.33-.06l6.68-2.49c.48-.18.73-.72.55-1.2-.18-.48-.72-.73-1.2-.55l-6.68,2.49c-.48.18-.73.72-.55,1.2.14.38.5.61.87.61\" fill=\"#a7a04d\"><\/path>\n  <path d=\"M31.81,27.87l6.06,3.11c.14.07.28.1.42.1.34,0,.67-.18.83-.51.23-.46.05-1.02-.4-1.25l-6.06-3.11c-.46-.23-1.02-.06-1.25.4-.24.46-.05,1.02.4,1.25\" fill=\"#a7a04d\"><\/path>\n  <path d=\"M28.9,46.07c-.47-.47-.73-1.11-.73-1.78s.26-1.31.73-1.78l6.84-6.84c.47-.47,1.11-.74,1.78-.74s1.31.26,1.78.74c.48.48.74,1.11.74,1.78s-.26,1.31-.74,1.78l-6.84,6.83c-.95.95-2.61.95-3.56,0M34.36,34.3l-6.83,6.84c-.84.84-1.31,1.96-1.31,3.15s.46,2.31,1.31,3.15c.84.84,1.96,1.31,3.15,1.31s2.31-.46,3.15-1.31l6.83-6.83c.84-.84,1.31-1.96,1.31-3.15s-.46-2.31-1.31-3.15c-1.68-1.68-4.62-1.68-6.3,0\" fill=\"#a7a04d\"><\/path>\n<\/svg><\/div><\/div>\n<\/div>\n<\/div>\n <\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-spacer stk-block-spacer stk--no-padding stk-block stk-af0c2a1\" id=\"strong-research-area-strong\" data-block-id=\"af0c2a1\"><style>.stk-af0c2a1 {height:30px !important;}<\/style><\/div>\n\n\n\n<div class=\"wp-block-greenshift-blocks-row alignwide gspb_row gspb_row-id-gsbp-2a38c9f gspb_row--gutter-20\" id=\"gspb_row-id-gsbp-2a38c9f\">\n<div class=\"wp-block-greenshift-blocks-row-column gspb_row__col--9 gspb_col-id-gsbp-2fbf50f\" id=\"gspb_col-id-gsbp-2fbf50f\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-133764c\" id=\"molecular-and-cellular-therapy\" data-block-id=\"133764c\"><style>.stk-133764c {margin-bottom:40px !important;}.stk-133764c .stk-block-heading__text{color:var(--theme-palette-color-3, #a7a04d) !important;}<\/style><h2 class=\"stk-block-heading__text has-text-color\">MOLECULAR AND CELLULAR THERAPY<\/h2><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-28e8a58\" id=\"strong-research-strong\" data-block-id=\"28e8a58\"><style>.stk-28e8a58 .stk-block-heading__text{color:var(--theme-palette-color-1, #164193) !important;}<\/style><h3 class=\"stk-block-heading__text has-text-color\"><strong>Research<\/strong><\/h3><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-b332380\" data-block-id=\"b332380\"><p class=\"stk-block-text__text\">Over the past 20 years, our research program has been guided by two core principles: addressing unmet medical needs and maintaining a strong translational focus. Our work integrates fundamental discovery with clinically oriented innovation, with the overarching goal of generating solutions that are both biologically impactful and medically relevant.<br>&nbsp;<br>Cancer therapy remains limited by tumor heterogeneity, rapid treatment resistance, and the challenges of safely delivering complex biologics. Dense tissue architecture and stromal barriers further restrict the penetration of antibodies, small molecules, and cellular therapies such as CAR-T cells, which also face significant toxicity, manufacturing, and cost challenges. As a result, relapse rates remain high, and the complexity and cost of multi-agent therapies threaten both clinical feasibility and long-term sustainability.<br>&nbsp;<br>To overcome these barriers, our program develops innovative approaches centered on oncolytic adenoviruses, mesenchymal stem cells (MSCs), and targeted CRISPR-Cas13 systems. Oncolytic adenoviruses provide tumor-selective replication, intratumoral amplification, and local release of therapeutic payloads, while MSCs enhance delivery by homing to tumors and protecting vectors from immune clearance. These platforms can be combined with CAR-T therapies for coordinated targeting of tumor cell populations.<br><br>Building on our laboratory long expertise in adenoviral vectors, we are advancing vaccine candidates against four infectious diseases: two for inhalation (SARS-CoV-2 and influenza) and two for intramuscular administration (chikungunya and yellow fever). These programs demonstrate the versatility of our vector platforms and their potential applications.<\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-a654e8d\" id=\"strong-skills-amp-tools-strong\" data-block-id=\"a654e8d\"><style>.stk-a654e8d .stk-block-heading__text{color:var(--theme-palette-color-1, #164193) !important;}<\/style><h3 class=\"stk-block-heading__text has-text-color\"><strong>Skills &amp; tools<\/strong><\/h3><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-260d7c4\" data-block-id=\"260d7c4\"><p class=\"stk-block-text__text\">By integrating those approaches, our strategy concentrates therapeutic activity within tumors, remodels the tumor microenvironment to convert \u201ccold\u201d tumors into \u201chot\u201d ones, reduces systemic toxicity, and aims to replace costly multi-drug regimens with multifunctional, scalable therapies capable of achieving durable cancer control.<br>&nbsp;<br>Our group maintains a strong research program in applied genomics, with a focus on underrepresented populations. A flagship initiative is the Molecular Profile of Breast Cancer Study (MPBCS), conducted within the Latin American Cancer Research Network (LACRN), which collected molecular, clinical, and epidemiological data from over 1,200 patients across Latin America. These studies characterized disease-relevant features including transcriptomic and molecular signatures, genetic ancestry, and socio-economic, clinical, and molecular determinants of disease. Similar approaches have been applied to rectal cancer and extended to a clinical and genetic study of Argentine patients with Stargardt disease.<br><br>We engineered a novel vaccine platform based on a chimeric human adenovirus 5 (hAdV5) vector. The vaccine platform (named CoroVaxG.3) was based on three pillars: (i) high expression of Spike to enhance its immunodominance by using a potent promoter and an mRNA stabilizer; (ii) enhanced infection of muscle and dendritic cells by replacing the fiber knob domain of hAdV5 by hAdV3; (iii) use of Spike stabilized in a prefusion conformation. We observed the development of cellular and humoral response and that nAbs did not wane even after 5 months. Administration of a novel version CorovaxG.3-D.FR in a prime\/boost regimen showed that a booster was able to increase the neutralizing capacity of the sera against all variants and fully protect aged K18-hACE2 mice against Omicron BA.1, as a BA.1-targeted vaccine did (see articles below).<\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-5168ba6\" id=\"strong-collaboration-interests-strong\" data-block-id=\"5168ba6\"><style>.stk-5168ba6 {margin-bottom:3px !important;}.stk-5168ba6 .stk-block-heading__text{color:var(--theme-palette-color-1, #164193) !important;}<\/style><h3 class=\"stk-block-heading__text has-text-color\"><strong>Collaboration interests<\/strong><\/h3><\/div>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Combination Immuno-Therapy Approaches<\/li>\n\n\n\n<li>In Vivo Imaging Studies in Preclinical Models<\/li>\n\n\n\n<li>Accelerating Translational Research to the Clinic<\/li>\n<\/ul>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-341a9f4\" id=\"strong-selected-publications-strong\" data-block-id=\"341a9f4\"><style>.stk-341a9f4 {margin-bottom:3px !important;}.stk-341a9f4 .stk-block-heading__text{color:var(--theme-palette-color-1, #164193) !important;}<\/style><h3 class=\"stk-block-heading__text has-text-color\"><strong>Selected publications<\/strong><\/h3><\/div>\n\n\n\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-193dbfa\" data-block-id=\"193dbfa\"><style>.stk-193dbfa {padding-left:0px !important;margin-bottom:var(--stk--preset--spacing--none, 0px) !important;}.stk-193dbfa-column{--stk-column-gap:var(--stk--preset--spacing--20, 0.44rem) !important;justify-content:flex-start !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-193dbfa-column stk--flex\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-f6f2387\" data-v=\"4\" data-block-id=\"f6f2387\"><style>.stk-f6f2387 {min-height:var(--stk--preset--block-height--none, 0px) !important;max-width:1500px !important;min-width:auto !important;padding-left:var(--stk--preset--spacing--none, 0px) !important;margin-right:auto !important;margin-left:var(--stk--preset--spacing--none, 0px) !important;}@media screen and (min-width:690px){.stk-f6f2387 {flex:var(--stk-flex-grow, 1) 1 calc(82% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-f6f2387-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-f6f2387-inner-blocks\">\n<ul class=\"wp-block-list\">\n<li style=\"margin-left:0\">RUSSO-MAENZA, Maria A., et al. Tackling cancer heterogeneity with systemically delivered oncolytic adenoviruses transcriptionally targeted with hybrid promoters.&nbsp;<em>Molecular Therapy Oncology<\/em>, 2025, vol. 33, no 4.<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-5a33621\" data-v=\"4\" data-block-id=\"5a33621\"><style>@media screen and (min-width:690px){.stk-5a33621 {flex:var(--stk-flex-grow, 1) 1 calc(18% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}@media screen and (max-width:689px){.stk-5a33621-container{margin-left:30px !important;}.stk-5a33621 {align-self:center !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-5a33621-container stk--no-background stk--no-padding\"><div class=\"has-text-align-left-mobile stk-block-content stk-inner-blocks stk-5a33621-inner-blocks\">\n<div class=\"wp-block-stackable-button-group stk-block-button-group stk-block stk-b873c6a\" data-block-id=\"b873c6a\"><div class=\"stk-row stk-inner-blocks stk-block-content stk-button-group\">\n<div class=\"wp-block-stackable-icon-button stk-block-icon-button stk-block stk-776b4f5\" data-block-id=\"776b4f5\"><style>.stk-776b4f5 .stk-button{background:var(--theme-palette-color-1, #164193) !important;}.stk-776b4f5 .stk-button:hover{background:var(--theme-palette-color-2, #312a74) !important;opacity:1 !important;}<\/style><a class=\"stk-link stk-button stk--hover-effect-darken\" href=\"https:\/\/www.cell.com\/molecular-therapy-family\/oncology\/fulltext\/S2950-3299(25)00142-0\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 640 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M579.8 267.7c56.5-56.5 56.5-148 0-204.5c-50-50-128.8-56.5-186.3-15.4l-1.6 1.1c-14.4 10.3-17.7 30.3-7.4 44.6s30.3 17.7 44.6 7.4l1.6-1.1c32.1-22.9 76-19.3 103.8 8.6c31.5 31.5 31.5 82.5 0 114L422.3 334.8c-31.5 31.5-82.5 31.5-114 0c-27.9-27.9-31.5-71.8-8.6-103.8l1.1-1.6c10.3-14.4 6.9-34.4-7.4-44.6s-34.4-6.9-44.6 7.4l-1.1 1.6C206.5 251.2 213 330 263 380c56.5 56.5 148 56.5 204.5 0L579.8 267.7zM60.2 244.3c-56.5 56.5-56.5 148 0 204.5c50 50 128.8 56.5 186.3 15.4l1.6-1.1c14.4-10.3 17.7-30.3 7.4-44.6s-30.3-17.7-44.6-7.4l-1.6 1.1c-32.1 22.9-76 19.3-103.8-8.6C74 372 74 321 105.5 289.5L217.7 177.2c31.5-31.5 82.5-31.5 114 0c27.9 27.9 31.5 71.8 8.6 103.9l-1.1 1.6c-10.3 14.4-6.9 34.4 7.4 44.6s34.4 6.9 44.6-7.4l1.1-1.6C433.5 260.8 427 182 377 132c-56.5-56.5-148-56.5-204.5 0L60.2 244.3z\"\/><\/svg><\/div><\/span><\/a><\/div>\n<\/div><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-divider alignfull stk-block-divider stk--hide-desktop has-text-align-center stk-block stk-a123428\" data-block-id=\"a123428\"><style>.stk-a123428 hr.stk-block-divider__hr{background:#abb8c3 !important;}@media screen and (max-width:689px){.stk-a123428 {align-items:center !important;margin-bottom:0px !important;display:flex !important;}}<\/style><hr class=\"stk-block-divider__hr\"\/><\/div>\n\n\n\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-5a54113\" data-block-id=\"5a54113\"><style>.stk-5a54113 {padding-left:0px !important;margin-bottom:var(--stk--preset--spacing--none, 0px) !important;}.stk-5a54113-column{--stk-column-gap:var(--stk--preset--spacing--20, 0.44rem) !important;justify-content:flex-start !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-5a54113-column stk--flex\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-4e5e1c5\" data-v=\"4\" data-block-id=\"4e5e1c5\"><style>.stk-4e5e1c5 {min-height:var(--stk--preset--block-height--none, 0px) !important;max-width:1500px !important;min-width:auto !important;padding-left:var(--stk--preset--spacing--none, 0px) !important;margin-right:auto !important;margin-left:var(--stk--preset--spacing--none, 0px) !important;}@media screen and (min-width:690px){.stk-4e5e1c5 {flex:var(--stk-flex-grow, 1) 1 calc(82% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-4e5e1c5-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-4e5e1c5-inner-blocks\">\n<ul class=\"wp-block-list\">\n<li style=\"margin-left:0\">QUINTA, Daniela Alves da, et al. Genetic Ancestry, Intrinsic Tumor Subtypes, and Breast Cancer Survival in Latin American Women. 2025.<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-ef8479e\" data-v=\"4\" data-block-id=\"ef8479e\"><style>@media screen and (min-width:690px){.stk-ef8479e {flex:var(--stk-flex-grow, 1) 1 calc(18% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}@media screen and (max-width:689px){.stk-ef8479e-container{margin-left:30px !important;}.stk-ef8479e {align-self:center !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-ef8479e-container stk--no-background stk--no-padding\"><div class=\"has-text-align-left-mobile stk-block-content stk-inner-blocks stk-ef8479e-inner-blocks\">\n<div class=\"wp-block-stackable-button-group stk-block-button-group stk-block stk-98399e6\" data-block-id=\"98399e6\"><div class=\"stk-row stk-inner-blocks stk-block-content stk-button-group\">\n<div class=\"wp-block-stackable-icon-button stk-block-icon-button stk-block stk-edb2ba1\" data-block-id=\"edb2ba1\"><style>.stk-edb2ba1 .stk-button{background:var(--theme-palette-color-1, #164193) !important;}.stk-edb2ba1 .stk-button:hover{background:var(--theme-palette-color-2, #312a74) !important;opacity:1 !important;}<\/style><a class=\"stk-link stk-button stk--hover-effect-darken\" href=\"https:\/\/observatorio.fm.usp.br\/entities\/publication\/0d51e094-44ce-4afa-8adc-c26fe2b65e6f\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 640 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M579.8 267.7c56.5-56.5 56.5-148 0-204.5c-50-50-128.8-56.5-186.3-15.4l-1.6 1.1c-14.4 10.3-17.7 30.3-7.4 44.6s30.3 17.7 44.6 7.4l1.6-1.1c32.1-22.9 76-19.3 103.8 8.6c31.5 31.5 31.5 82.5 0 114L422.3 334.8c-31.5 31.5-82.5 31.5-114 0c-27.9-27.9-31.5-71.8-8.6-103.8l1.1-1.6c10.3-14.4 6.9-34.4-7.4-44.6s-34.4-6.9-44.6 7.4l-1.1 1.6C206.5 251.2 213 330 263 380c56.5 56.5 148 56.5 204.5 0L579.8 267.7zM60.2 244.3c-56.5 56.5-56.5 148 0 204.5c50 50 128.8 56.5 186.3 15.4l1.6-1.1c14.4-10.3 17.7-30.3 7.4-44.6s-30.3-17.7-44.6-7.4l-1.6 1.1c-32.1 22.9-76 19.3-103.8-8.6C74 372 74 321 105.5 289.5L217.7 177.2c31.5-31.5 82.5-31.5 114 0c27.9 27.9 31.5 71.8 8.6 103.9l-1.1 1.6c-10.3 14.4-6.9 34.4 7.4 44.6s34.4 6.9 44.6-7.4l1.1-1.6C433.5 260.8 427 182 377 132c-56.5-56.5-148-56.5-204.5 0L60.2 244.3z\"\/><\/svg><\/div><\/span><\/a><\/div>\n<\/div><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-divider alignfull stk-block-divider stk--hide-desktop has-text-align-center stk-block stk-429f817\" data-block-id=\"429f817\"><style>.stk-429f817 hr.stk-block-divider__hr{background:#abb8c3 !important;}@media screen and (max-width:689px){.stk-429f817 {align-items:center !important;margin-bottom:0px !important;display:flex !important;}}<\/style><hr class=\"stk-block-divider__hr\"\/><\/div>\n\n\n\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-2cc98fc\" data-block-id=\"2cc98fc\"><style>.stk-2cc98fc {padding-left:0px !important;margin-bottom:var(--stk--preset--spacing--none, 0px) !important;}.stk-2cc98fc-column{--stk-column-gap:var(--stk--preset--spacing--20, 0.44rem) !important;justify-content:flex-start !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-2cc98fc-column stk--flex\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-2d73e22\" data-v=\"4\" data-block-id=\"2d73e22\"><style>.stk-2d73e22 {min-height:var(--stk--preset--block-height--none, 0px) !important;max-width:1500px !important;min-width:auto !important;padding-left:var(--stk--preset--spacing--none, 0px) !important;margin-right:auto !important;margin-left:var(--stk--preset--spacing--none, 0px) !important;}@media screen and (min-width:690px){.stk-2d73e22 {flex:var(--stk-flex-grow, 1) 1 calc(82% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-2d73e22-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-2d73e22-inner-blocks\">\n<ul class=\"wp-block-list\">\n<li style=\"margin-left:0\">ALFANO, Ana, et al. In vitro and in vivo efficacy of a stroma-targeted, tumor microenvironment responsive oncolytic adenovirus in different preclinical models of cancer.&nbsp;<em>International journal of molecular sciences<\/em>, 2023, vol. 24, no 12, p. 9992.<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-7f13117\" data-v=\"4\" data-block-id=\"7f13117\"><style>@media screen and (min-width:690px){.stk-7f13117 {flex:var(--stk-flex-grow, 1) 1 calc(18% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}@media screen and (max-width:689px){.stk-7f13117-container{margin-left:30px !important;}.stk-7f13117 {align-self:center !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-7f13117-container stk--no-background stk--no-padding\"><div class=\"has-text-align-left-mobile stk-block-content stk-inner-blocks stk-7f13117-inner-blocks\">\n<div class=\"wp-block-stackable-button-group stk-block-button-group stk-block stk-d13ba5c\" data-block-id=\"d13ba5c\"><div class=\"stk-row stk-inner-blocks stk-block-content stk-button-group\">\n<div class=\"wp-block-stackable-icon-button stk-block-icon-button stk-block stk-043b817\" data-block-id=\"043b817\"><style>.stk-043b817 .stk-button{background:var(--theme-palette-color-1, #164193) !important;}.stk-043b817 .stk-button:hover{background:var(--theme-palette-color-2, #312a74) !important;opacity:1 !important;}<\/style><a class=\"stk-link stk-button stk--hover-effect-darken\" href=\"https:\/\/www.mdpi.com\/1422-0067\/24\/12\/9992\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 640 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M579.8 267.7c56.5-56.5 56.5-148 0-204.5c-50-50-128.8-56.5-186.3-15.4l-1.6 1.1c-14.4 10.3-17.7 30.3-7.4 44.6s30.3 17.7 44.6 7.4l1.6-1.1c32.1-22.9 76-19.3 103.8 8.6c31.5 31.5 31.5 82.5 0 114L422.3 334.8c-31.5 31.5-82.5 31.5-114 0c-27.9-27.9-31.5-71.8-8.6-103.8l1.1-1.6c10.3-14.4 6.9-34.4-7.4-44.6s-34.4-6.9-44.6 7.4l-1.1 1.6C206.5 251.2 213 330 263 380c56.5 56.5 148 56.5 204.5 0L579.8 267.7zM60.2 244.3c-56.5 56.5-56.5 148 0 204.5c50 50 128.8 56.5 186.3 15.4l1.6-1.1c14.4-10.3 17.7-30.3 7.4-44.6s-30.3-17.7-44.6-7.4l-1.6 1.1c-32.1 22.9-76 19.3-103.8-8.6C74 372 74 321 105.5 289.5L217.7 177.2c31.5-31.5 82.5-31.5 114 0c27.9 27.9 31.5 71.8 8.6 103.9l-1.1 1.6c-10.3 14.4-6.9 34.4 7.4 44.6s34.4 6.9 44.6-7.4l1.1-1.6C433.5 260.8 427 182 377 132c-56.5-56.5-148-56.5-204.5 0L60.2 244.3z\"\/><\/svg><\/div><\/span><\/a><\/div>\n<\/div><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-divider alignfull stk-block-divider stk--hide-desktop has-text-align-center stk-block stk-91225dd\" data-block-id=\"91225dd\"><style>.stk-91225dd hr.stk-block-divider__hr{background:#abb8c3 !important;}@media screen and (max-width:689px){.stk-91225dd {align-items:center !important;margin-bottom:0px !important;display:flex !important;}}<\/style><hr class=\"stk-block-divider__hr\"\/><\/div>\n\n\n\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-5014f1a\" data-block-id=\"5014f1a\"><style>.stk-5014f1a {padding-left:0px !important;margin-bottom:var(--stk--preset--spacing--none, 0px) !important;}.stk-5014f1a-column{--stk-column-gap:var(--stk--preset--spacing--20, 0.44rem) !important;justify-content:flex-start !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-5014f1a-column stk--flex\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-87657ba\" data-v=\"4\" data-block-id=\"87657ba\"><style>.stk-87657ba {min-height:var(--stk--preset--block-height--none, 0px) !important;max-width:1500px !important;min-width:auto !important;padding-left:var(--stk--preset--spacing--none, 0px) !important;margin-right:auto !important;margin-left:var(--stk--preset--spacing--none, 0px) !important;}@media screen and (min-width:690px){.stk-87657ba {flex:var(--stk-flex-grow, 1) 1 calc(82% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-87657ba-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-87657ba-inner-blocks\">\n<ul class=\"wp-block-list\">\n<li style=\"margin-left:0\">L\u00d3PEZ, M. Ver\u00f3nica, et al. A single dose of a hybrid hAdV5-based anti-COVID-19 vaccine induces a long-lasting immune response and broad coverage against VOC.&nbsp;<em>Vaccines<\/em>, 2021, vol. 9, no 10, p. 1106.<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-e551457\" data-v=\"4\" data-block-id=\"e551457\"><style>@media screen and (min-width:690px){.stk-e551457 {flex:var(--stk-flex-grow, 1) 1 calc(18% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}@media screen and (max-width:689px){.stk-e551457-container{margin-left:30px !important;}.stk-e551457 {align-self:center !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-e551457-container stk--no-background stk--no-padding\"><div class=\"has-text-align-left-mobile stk-block-content stk-inner-blocks stk-e551457-inner-blocks\">\n<div class=\"wp-block-stackable-button-group stk-block-button-group stk-block stk-809b41e\" data-block-id=\"809b41e\"><div class=\"stk-row stk-inner-blocks stk-block-content stk-button-group\">\n<div class=\"wp-block-stackable-icon-button stk-block-icon-button stk-block stk-1aa514a\" data-block-id=\"1aa514a\"><style>.stk-1aa514a .stk-button{background:var(--theme-palette-color-1, #164193) !important;}.stk-1aa514a .stk-button:hover{background:var(--theme-palette-color-2, #312a74) !important;opacity:1 !important;}<\/style><a class=\"stk-link stk-button stk--hover-effect-darken\" href=\"https:\/\/www.mdpi.com\/2076-393X\/9\/10\/1106\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 640 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M579.8 267.7c56.5-56.5 56.5-148 0-204.5c-50-50-128.8-56.5-186.3-15.4l-1.6 1.1c-14.4 10.3-17.7 30.3-7.4 44.6s30.3 17.7 44.6 7.4l1.6-1.1c32.1-22.9 76-19.3 103.8 8.6c31.5 31.5 31.5 82.5 0 114L422.3 334.8c-31.5 31.5-82.5 31.5-114 0c-27.9-27.9-31.5-71.8-8.6-103.8l1.1-1.6c10.3-14.4 6.9-34.4-7.4-44.6s-34.4-6.9-44.6 7.4l-1.1 1.6C206.5 251.2 213 330 263 380c56.5 56.5 148 56.5 204.5 0L579.8 267.7zM60.2 244.3c-56.5 56.5-56.5 148 0 204.5c50 50 128.8 56.5 186.3 15.4l1.6-1.1c14.4-10.3 17.7-30.3 7.4-44.6s-30.3-17.7-44.6-7.4l-1.6 1.1c-32.1 22.9-76 19.3-103.8-8.6C74 372 74 321 105.5 289.5L217.7 177.2c31.5-31.5 82.5-31.5 114 0c27.9 27.9 31.5 71.8 8.6 103.9l-1.1 1.6c-10.3 14.4-6.9 34.4 7.4 44.6s34.4 6.9 44.6-7.4l1.1-1.6C433.5 260.8 427 182 377 132c-56.5-56.5-148-56.5-204.5 0L60.2 244.3z\"\/><\/svg><\/div><\/span><\/a><\/div>\n<\/div><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-divider alignfull stk-block-divider stk--hide-desktop has-text-align-center stk-block stk-8e75ce2\" data-block-id=\"8e75ce2\"><style>.stk-8e75ce2 hr.stk-block-divider__hr{background:#abb8c3 !important;}@media screen and (max-width:689px){.stk-8e75ce2 {align-items:center !important;margin-bottom:0px !important;display:flex !important;}}<\/style><hr class=\"stk-block-divider__hr\"\/><\/div>\n\n\n\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-ce7b989\" data-block-id=\"ce7b989\"><style>.stk-ce7b989 {padding-left:0px !important;margin-bottom:var(--stk--preset--spacing--none, 0px) !important;}.stk-ce7b989-column{--stk-column-gap:var(--stk--preset--spacing--20, 0.44rem) !important;justify-content:flex-start !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-ce7b989-column stk--flex\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-6648333\" data-v=\"4\" data-block-id=\"6648333\"><style>.stk-6648333 {min-height:var(--stk--preset--block-height--none, 0px) !important;max-width:1500px !important;min-width:auto !important;padding-left:var(--stk--preset--spacing--none, 0px) !important;margin-right:auto !important;margin-left:var(--stk--preset--spacing--none, 0px) !important;}@media screen and (min-width:690px){.stk-6648333 {flex:var(--stk-flex-grow, 1) 1 calc(82% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-6648333-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-6648333-inner-blocks\">\n<ul class=\"wp-block-list\">\n<li style=\"margin-left:0\">SILVA, Berenice Anabel, et al. Do immunosuppressive treatments influence immune responses against adenovirus-based COVID-19 vaccines in patients with multiple sclerosis? An Argentine multicenter study.&nbsp;<em>Frontiers in Immunology<\/em>, 2024, vol. 15, p. 1431403.<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-8e705a1\" data-v=\"4\" data-block-id=\"8e705a1\"><style>@media screen and (min-width:690px){.stk-8e705a1 {flex:var(--stk-flex-grow, 1) 1 calc(18% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}@media screen and (max-width:689px){.stk-8e705a1-container{margin-left:30px !important;}.stk-8e705a1 {align-self:center !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-8e705a1-container stk--no-background stk--no-padding\"><div class=\"has-text-align-left-mobile stk-block-content stk-inner-blocks stk-8e705a1-inner-blocks\">\n<div class=\"wp-block-stackable-button-group stk-block-button-group stk-block stk-4c00d7d\" data-block-id=\"4c00d7d\"><div class=\"stk-row stk-inner-blocks stk-block-content stk-button-group\">\n<div class=\"wp-block-stackable-icon-button stk-block-icon-button stk-block stk-dc32512\" data-block-id=\"dc32512\"><style>.stk-dc32512 .stk-button{background:var(--theme-palette-color-1, #164193) !important;}.stk-dc32512 .stk-button:hover{background:var(--theme-palette-color-2, #312a74) !important;opacity:1 !important;}<\/style><a class=\"stk-link stk-button stk--hover-effect-darken\" href=\"https:\/\/www.frontiersin.org\/journals\/immunology\/articles\/10.3389\/fimmu.2024.1431403\/full\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 640 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M579.8 267.7c56.5-56.5 56.5-148 0-204.5c-50-50-128.8-56.5-186.3-15.4l-1.6 1.1c-14.4 10.3-17.7 30.3-7.4 44.6s30.3 17.7 44.6 7.4l1.6-1.1c32.1-22.9 76-19.3 103.8 8.6c31.5 31.5 31.5 82.5 0 114L422.3 334.8c-31.5 31.5-82.5 31.5-114 0c-27.9-27.9-31.5-71.8-8.6-103.8l1.1-1.6c10.3-14.4 6.9-34.4-7.4-44.6s-34.4-6.9-44.6 7.4l-1.1 1.6C206.5 251.2 213 330 263 380c56.5 56.5 148 56.5 204.5 0L579.8 267.7zM60.2 244.3c-56.5 56.5-56.5 148 0 204.5c50 50 128.8 56.5 186.3 15.4l1.6-1.1c14.4-10.3 17.7-30.3 7.4-44.6s-30.3-17.7-44.6-7.4l-1.6 1.1c-32.1 22.9-76 19.3-103.8-8.6C74 372 74 321 105.5 289.5L217.7 177.2c31.5-31.5 82.5-31.5 114 0c27.9 27.9 31.5 71.8 8.6 103.9l-1.1 1.6c-10.3 14.4-6.9 34.4 7.4 44.6s34.4 6.9 44.6-7.4l1.1-1.6C433.5 260.8 427 182 377 132c-56.5-56.5-148-56.5-204.5 0L60.2 244.3z\"\/><\/svg><\/div><\/span><\/a><\/div>\n<\/div><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-divider alignfull stk-block-divider stk--hide-desktop has-text-align-center stk-block stk-27f8056\" data-block-id=\"27f8056\"><style>.stk-27f8056 hr.stk-block-divider__hr{background:#abb8c3 !important;}@media screen and (max-width:689px){.stk-27f8056 {align-items:center !important;margin-bottom:0px !important;display:flex !important;}}<\/style><hr class=\"stk-block-divider__hr\"\/><\/div>\n\n\n\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-d263e6c\" data-block-id=\"d263e6c\"><style>.stk-d263e6c {padding-left:0px !important;margin-bottom:var(--stk--preset--spacing--none, 0px) !important;}.stk-d263e6c-column{--stk-column-gap:var(--stk--preset--spacing--20, 0.44rem) !important;justify-content:flex-start !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-d263e6c-column stk--flex\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-7106ab5\" data-v=\"4\" data-block-id=\"7106ab5\"><style>.stk-7106ab5 {min-height:var(--stk--preset--block-height--none, 0px) !important;max-width:1500px !important;min-width:auto !important;padding-left:var(--stk--preset--spacing--none, 0px) !important;margin-right:auto !important;margin-left:var(--stk--preset--spacing--none, 0px) !important;}@media screen and (min-width:690px){.stk-7106ab5 {flex:var(--stk-flex-grow, 1) 1 calc(82% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-7106ab5-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-7106ab5-inner-blocks\">\n<ul class=\"wp-block-list\">\n<li style=\"margin-left:0\">VINZ\u00d3N, Sabrina E., et al. Cross-protection and cross-neutralization capacity of ancestral and VOC-matched SARS-CoV-2 adenoviral vector-based vaccines.&nbsp;<em>npj Vaccines<\/em>, 2023, vol. 8, no 1, p. 149.<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-0b894d9\" data-v=\"4\" data-block-id=\"0b894d9\"><style>@media screen and (min-width:690px){.stk-0b894d9 {flex:var(--stk-flex-grow, 1) 1 calc(18% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}@media screen and (max-width:689px){.stk-0b894d9-container{margin-left:30px !important;}.stk-0b894d9 {align-self:center !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-0b894d9-container stk--no-background stk--no-padding\"><div class=\"has-text-align-left-mobile stk-block-content stk-inner-blocks stk-0b894d9-inner-blocks\">\n<div class=\"wp-block-stackable-button-group stk-block-button-group stk-block stk-bcfba12\" data-block-id=\"bcfba12\"><div class=\"stk-row stk-inner-blocks stk-block-content stk-button-group\">\n<div class=\"wp-block-stackable-icon-button stk-block-icon-button stk-block stk-c2fdf61\" data-block-id=\"c2fdf61\"><style>.stk-c2fdf61 .stk-button{background:var(--theme-palette-color-1, #164193) !important;}.stk-c2fdf61 .stk-button:hover{background:var(--theme-palette-color-2, #312a74) !important;opacity:1 !important;}<\/style><a class=\"stk-link stk-button stk--hover-effect-darken\" href=\"https:\/\/www.nature.com\/articles\/s41541-023-00737-4\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 640 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M579.8 267.7c56.5-56.5 56.5-148 0-204.5c-50-50-128.8-56.5-186.3-15.4l-1.6 1.1c-14.4 10.3-17.7 30.3-7.4 44.6s30.3 17.7 44.6 7.4l1.6-1.1c32.1-22.9 76-19.3 103.8 8.6c31.5 31.5 31.5 82.5 0 114L422.3 334.8c-31.5 31.5-82.5 31.5-114 0c-27.9-27.9-31.5-71.8-8.6-103.8l1.1-1.6c10.3-14.4 6.9-34.4-7.4-44.6s-34.4-6.9-44.6 7.4l-1.1 1.6C206.5 251.2 213 330 263 380c56.5 56.5 148 56.5 204.5 0L579.8 267.7zM60.2 244.3c-56.5 56.5-56.5 148 0 204.5c50 50 128.8 56.5 186.3 15.4l1.6-1.1c14.4-10.3 17.7-30.3 7.4-44.6s-30.3-17.7-44.6-7.4l-1.6 1.1c-32.1 22.9-76 19.3-103.8-8.6C74 372 74 321 105.5 289.5L217.7 177.2c31.5-31.5 82.5-31.5 114 0c27.9 27.9 31.5 71.8 8.6 103.9l-1.1 1.6c-10.3 14.4-6.9 34.4 7.4 44.6s34.4 6.9 44.6-7.4l1.1-1.6C433.5 260.8 427 182 377 132c-56.5-56.5-148-56.5-204.5 0L60.2 244.3z\"\/><\/svg><\/div><\/span><\/a><\/div>\n<\/div><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-divider alignfull stk-block-divider stk--hide-desktop has-text-align-center stk-block stk-f18fe18\" data-block-id=\"f18fe18\"><style>.stk-f18fe18 hr.stk-block-divider__hr{background:#abb8c3 !important;}@media screen and (max-width:689px){.stk-f18fe18 {align-items:center !important;margin-bottom:0px !important;display:flex !important;}}<\/style><hr class=\"stk-block-divider__hr\"\/><\/div>\n\n\n\n<div class=\"wp-block-stackable-spacer stk-block-spacer stk--no-padding stk-block stk-9f3d337\" data-block-id=\"9f3d337\"><style>.stk-9f3d337 {height:30px !important;}<\/style><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-greenshift-blocks-row-column gspb_row__col--3 gspb_col-id-gsbp-6a5e99e\" id=\"gspb_col-id-gsbp-6a5e99e\">\n<div class=\"wp-block-stackable-image stk-block-image stk-block stk-30062fb\" data-block-id=\"30062fb\"><style>.stk-30062fb .stk-img-wrapper{width:80% !important;}<\/style><figure><span class=\"stk-img-wrapper stk-image--shape-stretch\"><img loading=\"lazy\" decoding=\"async\" class=\"stk-img wp-image-1158\" src=\"https:\/\/www.leloir.org.ar\/research\/wp-content\/uploads\/2026\/06\/Fil__Podhajcer.png\" width=\"400\" height=\"400\" srcset=\"https:\/\/www.leloir.org.ar\/research\/wp-content\/uploads\/2026\/06\/Fil__Podhajcer.png 400w, https:\/\/www.leloir.org.ar\/research\/wp-content\/uploads\/2026\/06\/Fil__Podhajcer-300x300.png 300w, https:\/\/www.leloir.org.ar\/research\/wp-content\/uploads\/2026\/06\/Fil__Podhajcer-150x150.png 150w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/span><\/figure><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-2075d5d\" data-block-id=\"2075d5d\"><style>.stk-2075d5d {margin-bottom:0px !important;}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #ffffff;\" class=\"stk-highlight\">Principal investigator<\/span><\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-b752a64\" id=\"osvaldo-podhajcer-ph-d\" data-block-id=\"b752a64\"><style>.stk-b752a64 .stk-block-heading__text{line-height:1.2em !important;}<\/style><h4 class=\"stk-block-heading__text\">Osvaldo Podhajcer, PhD<\/h4><\/div>\n\n\n\n<div class=\"wp-block-stackable-icon-label stk-block-icon-label stk-block stk-b51f5e0\" data-block-id=\"b51f5e0\"><style>.stk-b51f5e0 .stk-inner-blocks{gap:10px !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content\">\n<div class=\"wp-block-stackable-icon stk-block-icon has-text-align-left stk-block stk-e43d088\" data-block-id=\"e43d088\"><style>.stk-e43d088 .stk--svg-wrapper .stk--inner-svg svg:last-child{height:22px !important;width:22px !important;}.stk-e43d088 .stk--svg-wrapper .stk--inner-svg svg:last-child, .stk-e43d088 .stk--svg-wrapper .stk--inner-svg svg:last-child :is(g, path, rect, polygon, ellipse){fill:var(--theme-palette-color-5, #35b6b4) !important;}<\/style><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg style=\"height:0;width:0\"><defs><linearGradient id=\"linear-gradient-e43d088\" x1=\"0\" x2=\"100%\" y1=\"0\" y2=\"0\"><stop offset=\"0%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-e-43-d-088-color-1)\"><\/stop><stop offset=\"100%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-e-43-d-088-color-2)\"><\/stop><\/linearGradient><\/defs><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M64 112c-8.8 0-16 7.2-16 16v22.1L220.5 291.7c20.7 17 50.4 17 71.1 0L464 150.1V128c0-8.8-7.2-16-16-16H64zM48 212.2V384c0 8.8 7.2 16 16 16H448c8.8 0 16-7.2 16-16V212.2L322 328.8c-38.4 31.5-93.7 31.5-132 0L48 212.2zM0 128C0 92.7 28.7 64 64 64H448c35.3 0 64 28.7 64 64V384c0 35.3-28.7 64-64 64H64c-35.3 0-64-28.7-64-64V128z\"\/><\/svg><\/div><\/span><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-09109d8\" id=\"strong-a-href-mailto-opodhajcer-leloir-org-ar-opodhajcer-leloir-org-ar-a-strong\" data-block-id=\"09109d8\"><style>.stk-09109d8 .stk-block-heading__text{font-size:1.2rem !important;color:var(--theme-palette-color-5, #35b6b4) !important;}@media screen and (max-width:999px){.stk-09109d8 .stk-block-heading__text{font-size:1.2rem !important;}}<\/style><p class=\"stk-block-heading__text has-text-color\"><strong><a href=\"mailto:opodhajcer@leloir.org.ar\">opodhajcer@leloir.org.ar<\/a><\/strong><\/p><\/div>\n<\/div><\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-11caa78\" data-block-id=\"11caa78\"><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-11caa78-column\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-5123533\" data-v=\"4\" data-block-id=\"5123533\"><style>@media screen and (min-width:690px){.stk-5123533 {flex:var(--stk-flex-grow, 1) 1 calc(20% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-5123533-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-5123533-inner-blocks\">\n<div class=\"wp-block-stackable-icon stk-block-icon stk-block stk-6a46513\" data-block-id=\"6a46513\"><style>.stk-6a46513 .stk--svg-wrapper .stk--inner-svg svg:last-child{height:18px !important;width:18px !important;}.stk-6a46513 .stk--svg-wrapper .stk--inner-svg svg:last-child, .stk-6a46513 .stk--svg-wrapper .stk--inner-svg svg:last-child :is(g, path, rect, polygon, ellipse){fill:var(--theme-palette-color-3, #a7a04d) !important;}<\/style><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg style=\"height:0;width:0\"><defs><linearGradient id=\"linear-gradient-6a46513\" x1=\"0\" x2=\"100%\" y1=\"0\" y2=\"0\"><stop offset=\"0%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-6-a-46513-color-1)\"><\/stop><stop offset=\"100%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-6-a-46513-color-2)\"><\/stop><\/linearGradient><\/defs><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M336 352c97.2 0 176-78.8 176-176S433.2 0 336 0S160 78.8 160 176c0 18.7 2.9 36.8 8.3 53.7L7 391c-4.5 4.5-7 10.6-7 17v80c0 13.3 10.7 24 24 24h80c13.3 0 24-10.7 24-24V448h40c13.3 0 24-10.7 24-24V384h40c6.4 0 12.5-2.5 17-7l33.3-33.3c16.9 5.4 35 8.3 53.7 8.3zM376 96a40 40 0 1 1 0 80 40 40 0 1 1 0-80z\"\/><\/svg><\/div><\/span><\/div>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-566cc73\" data-v=\"4\" data-block-id=\"566cc73\"><style>@media screen and (min-width:690px){.stk-566cc73 {flex:var(--stk-flex-grow, 1) 1 calc(80% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-566cc73-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-566cc73-inner-blocks\">\n<ul style=\"padding-right:0;padding-left:0\" class=\"wp-block-list\">\n<li class=\"has-palette-color-3-color has-text-color has-link-color wp-elements-1\" style=\"line-height:1.3\">oncolytic adenoviruses<br><\/li>\n\n\n\n<li class=\"has-palette-color-3-color has-text-color has-link-color wp-elements-2\" style=\"line-height:1.3\">cancer immunotherapy<br><\/li>\n\n\n\n<li class=\"has-palette-color-3-color has-text-color has-link-color wp-elements-3\" style=\"line-height:1.3\">tumor microenvironment<br><\/li>\n\n\n\n<li class=\"has-palette-color-3-color has-text-color has-link-color wp-elements-4\" style=\"line-height:1.3\"> CRISPR cancer research<br><\/li>\n\n\n\n<li class=\"has-palette-color-3-color has-text-color has-link-color wp-elements-5\" style=\"line-height:1.3\">translational oncology<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n<\/div><\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_gspb_post_css":"#gspb_row-id-gsbp-2a38c9f,#gspb_row-id-gsbp-5a0b21f{justify-content:space-between;margin-top:0;display:flex;flex-wrap:wrap;margin-bottom:0}#gspb_row-id-gsbp-2a38c9f>.gspb_row__content{display:flex;justify-content:space-between;margin:0 auto;width:100%;flex-wrap:wrap}.gspb_row{position:relative}div[id^=gspb_col-id]{box-sizing:border-box;position:relative;padding:var(--gs-row-column-padding, 15px min(3vw, 20px))}#gspb_col-id-gsbp-2fbf50f.gspb_row__col--9{width:calc(75% - 10px)}@media (max-width:991.98px){#gspb_col-id-gsbp-2fbf50f.gspb_row__col--9{width:calc(75% - 10px)}}@media (max-width:767.98px){#gspb_col-id-gsbp-2fbf50f.gspb_row__col--9{width:calc(75% - 10px)}}@media 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