{"id":1176,"date":"2026-06-25T11:11:24","date_gmt":"2026-06-25T14:11:24","guid":{"rendered":"https:\/\/www.leloir.org.ar\/research\/?page_id=1176"},"modified":"2026-07-07T11:37:15","modified_gmt":"2026-07-07T14:37:15","slug":"cell-cycle-and-genomic-stability","status":"publish","type":"page","link":"https:\/\/www.leloir.org.ar\/research\/cell-cycle-and-genomic-stability\/","title":{"rendered":"cell cycle and genomic stability"},"content":{"rendered":"\n<div class=\"wp-block-stackable-spacer stk-block-spacer stk--no-padding stk-block stk-66162b7\" id=\"strong-research-area-strong\" data-block-id=\"66162b7\"><style>.stk-66162b7 {height:20px !important;}<\/style><\/div>\n\n\n\n<div class=\"wp-block-stackable-columns alignfull stk-block-columns stk--hide-mobile stk-block stk-efbfbbe\" data-block-id=\"efbfbbe\"><style>.stk-efbfbbe {margin-bottom:0px !important;top:0px !important;left:0px !important;}.stk-efbfbbe-column{max-width:496px !important;min-width:auto !important;margin-right:auto !important;margin-left:0px !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-efbfbbe-column alignfull\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-095be29 stk-block-background\" data-v=\"4\" data-block-id=\"095be29\"><style>.stk-095be29-container{margin-top:var(--stk--preset--spacing--none, 0px) !important;margin-right:auto !important;margin-bottom:var(--stk--preset--spacing--none, 0px) !important;margin-left:0px !important;max-width:100% !important;min-width:auto !important;}.stk-095be29 {align-self:center !important;background-color:var(--theme-palette-color-1, #164193) !important;border-top-right-radius:var(--stk--preset--border-radius--full, 9999px) !important;border-bottom-right-radius:var(--stk--preset--border-radius--full, 9999px) !important;border-bottom-left-radius:var(--stk--preset--border-radius--none, 0px) !important;overflow:hidden !important;min-height:var(--stk--preset--block-height--none, 0px) !important;align-items:center !important;max-width:100% !important;min-width:auto !important;padding-top:var(--stk--preset--spacing--none, 0px) !important;padding-bottom:var(--stk--preset--spacing--none, 0px) !important;padding-left:60px !important;margin-top:var(--stk--preset--spacing--none, 0px) !important;margin-right:auto !important;margin-left:0px !important;display:flex !important;}.stk-095be29-inner-blocks{justify-content:space-around !important;column-gap:0px !important;}.stk-095be29:before{background-color:var(--theme-palette-color-1, #164193) !important;}@media screen and (min-width:690px){.stk-095be29 {flex:var(--stk-flex-grow, 1) 1 calc(66.666% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-095be29-container stk--no-background stk--no-padding\"><div class=\"has-text-align-left stk--block-horizontal-flex stk--column-flex stk-block-content stk-inner-blocks stk-095be29-inner-blocks\">\n<div class=\"wp-block-stackable-columns alignfull stk-block-columns stk-block stk-a3b5388\" data-block-id=\"a3b5388\"><style>.stk-a3b5388 {padding-top:var(--stk--preset--spacing--none, 0px) !important;padding-right:0px !important;padding-bottom:var(--stk--preset--spacing--none, 0px) !important;padding-left:var(--stk--preset--spacing--none, 0px) !important;margin-left:var(--stk--preset--spacing--none, 0px) !important;}.stk-a3b5388-column{justify-content:space-between !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-a3b5388-column stk--flex alignfull\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-ec743fe\" data-v=\"4\" data-block-id=\"ec743fe\"><style>.stk-ec743fe-container{margin-top:var(--stk--preset--spacing--none, 0px) !important;margin-right:var(--stk--preset--spacing--none, 0px) !important;margin-bottom:var(--stk--preset--spacing--none, 0px) !important;margin-left:var(--stk--preset--spacing--none, 0px) !important;padding-left:var(--stk--preset--spacing--none, 0px) !important;}.stk-ec743fe {align-items:center !important;padding-top:0px !important;padding-right:0px !important;padding-bottom:0px !important;padding-left:0px !important;margin-top:0px !important;margin-right:0px !important;margin-bottom:0px !important;margin-left:0px !important;display:flex !important;}@media screen and (min-width:690px){.stk-ec743fe {flex:var(--stk-flex-grow, 1) 1 calc(56% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-ec743fe-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-ec743fe-inner-blocks\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-0108191\" id=\"strong-research-area-strong\" data-block-id=\"0108191\"><style>.stk-0108191 {margin-bottom:0px !important;}.stk-0108191 .stk-block-heading__text{color:var(--theme-palette-color-3, #a7a04d) !important;}<\/style><h6 class=\"stk-block-heading__text has-text-color\"><strong>Research area<\/strong><\/h6><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-0b4b126\" id=\"strong-cancer-strong\" data-block-id=\"0b4b126\"><style>.stk-0b4b126 {align-items:flex-start !important;padding-top:var(--stk--preset--spacing--none, 0px) !important;padding-bottom:var(--stk--preset--spacing--none, 0px) !important;margin-top:var(--stk--preset--spacing--none, 0px) !important;margin-bottom:var(--stk--preset--spacing--none, 0px) !important;margin-left:var(--stk--preset--spacing--none, 0px) !important;display:flex !important;}<\/style><h5 class=\"stk-block-heading__text\"><strong>Cancer<\/strong><\/h5><\/div>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-4110096\" data-v=\"4\" data-block-id=\"4110096\"><style>.stk-4110096-container{margin-top:5px !important;margin-right:0px !important;margin-bottom:5px !important;margin-left:0px !important;}.stk-4110096 {align-self:center !important;align-items:center !important;padding-top:var(--stk--preset--spacing--none, 0px) !important;padding-right:var(--stk--preset--spacing--none, 0px) !important;padding-bottom:var(--stk--preset--spacing--none, 0px) !important;padding-left:var(--stk--preset--spacing--none, 0px) !important;margin-top:0px !important;margin-right:0px !important;margin-bottom:0px !important;margin-left:0px !important;display:flex !important;}.stk-4110096-inner-blocks{align-items:center !important;column-gap:0px !important;}@media screen and (min-width:690px){.stk-4110096 {flex:var(--stk-flex-grow, 1) 1 calc(44% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-4110096-container stk--no-background stk--no-padding\"><div class=\"has-text-align-center stk--block-horizontal-flex stk--column-flex stk-block-content stk-inner-blocks stk-4110096-inner-blocks\">\n<div class=\"wp-block-stackable-image stk-block-image stk-block stk-5f46d71\" data-block-id=\"5f46d71\"><style>.stk-5f46d71 .stk-img-wrapper{width:70% !important;}<\/style><figure><span class=\"stk-img-wrapper stk-image--shape-stretch\"><img loading=\"lazy\" decoding=\"async\" class=\"stk-img wp-image-1057\" src=\"https:\/\/www.leloir.org.ar\/research\/wp-content\/uploads\/2026\/05\/cancer-03.png\" width=\"100\" height=\"100\"\/><\/span><\/figure><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-9284d94\" data-v=\"4\" data-block-id=\"9284d94\"><style>@media screen and (min-width:690px){.stk-9284d94 {flex:var(--stk-flex-grow, 1) 1 calc(33.334% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-9284d94-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-9284d94-inner-blocks\"><\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-greenshift-blocks-container alignfull gspb_container gspb_container-gsbp-c15c419\" id=\"gspb_container-id-gsbp-c15c419\">\n<div class=\"wp-block-greenshift-blocks-row gspb_row gspb_row-id-gsbp-18a8bbc\" id=\"gspb_row-id-gsbp-18a8bbc\"><div class=\"gspb_row__content\"> \n<div class=\"wp-block-greenshift-blocks-row-column gspb_row__col--6 gspb_row__col--xs-9 gspb_col-id-gsbp-1de9e8b\" id=\"gspb_col-id-gsbp-1de9e8b\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-fe81fce\" id=\"strong-research-area-strong\" data-block-id=\"fe81fce\"><style>.stk-fe81fce .stk-block-heading__text{color:var(--theme-palette-color-3, #a7a04d) !important;}@media screen and (max-width:689px){.stk-fe81fce {padding-bottom:0px !important;margin-bottom:0px !important;}}<\/style><h6 class=\"stk-block-heading__text has-text-color\"><strong>Research area<\/strong><\/h6><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-f5d6339\" id=\"strong-research-area-strong\" data-block-id=\"f5d6339\"><style>@media screen and (max-width:689px){.stk-f5d6339 {align-items:flex-start !important;padding-top:0px !important;padding-right:0px !important;padding-bottom:0px !important;padding-left:0px !important;margin-bottom:0px !important;display:flex !important;}}<\/style><h5 class=\"stk-block-heading__text has-text-align-left-mobile\"><strong>Cancer<\/strong><\/h5><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-greenshift-blocks-row-column gspb_row__col--6 gspb_row__col--xs-3 gspb_col-id-gsbp-643144c\" id=\"gspb_col-id-gsbp-643144c\">\n<div class=\"wp-block-stackable-image stk-block-image stk-block stk-aaae08c\" data-block-id=\"aaae08c\"><style>@media screen and (max-width:689px){.stk-aaae08c .stk-img-wrapper{width:70% !important;}}<\/style><figure><span class=\"stk-img-wrapper stk-image--shape-stretch\"><img loading=\"lazy\" decoding=\"async\" class=\"stk-img wp-image-1057\" src=\"https:\/\/www.leloir.org.ar\/research\/wp-content\/uploads\/2026\/05\/cancer-03.png\" width=\"100\" height=\"100\"\/><\/span><\/figure><\/div>\n<\/div>\n <\/div><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-stackable-spacer stk-block-spacer stk--no-padding stk-block stk-af0c2a1\" id=\"strong-research-area-strong\" data-block-id=\"af0c2a1\"><style>.stk-af0c2a1 {height:30px !important;}<\/style><\/div>\n\n\n\n<div class=\"wp-block-greenshift-blocks-row alignwide gspb_row gspb_row-id-gsbp-2a38c9f gspb_row--gutter-20\" id=\"gspb_row-id-gsbp-2a38c9f\">\n<div class=\"wp-block-greenshift-blocks-row-column gspb_row__col--9 gspb_col-id-gsbp-2fbf50f\" id=\"gspb_col-id-gsbp-2fbf50f\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-133764c\" id=\"cell-cycle-and-genomic-stability\" data-block-id=\"133764c\"><style>.stk-133764c {margin-bottom:40px !important;}.stk-133764c .stk-block-heading__text{color:var(--theme-palette-color-3, #a7a04d) !important;}<\/style><h2 class=\"stk-block-heading__text has-text-color\">CELL CYCLE AND GENOMIC STABILITY<\/h2><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-28e8a58\" id=\"strong-research-strong\" data-block-id=\"28e8a58\"><style>.stk-28e8a58 .stk-block-heading__text{color:var(--theme-palette-color-1, #164193) !important;}<\/style><h3 class=\"stk-block-heading__text has-text-color\"><strong>Research<\/strong><\/h3><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-b332380\" data-block-id=\"b332380\"><p class=\"stk-block-text__text\">DNA replication is fundamental to life but also underpins diseases such as cancer. The identification of molecular pathways that differentiate cancer cells from healthy ones, has led to the discovery of critical therapeutic tools that selectively impair DNA replication in cancer cells. Our work has focused on the identification of factors that impair mechanisms of adaptation of DNA replication to the damaged DNA templates that accumulate after chemotherapy. Our research has revealed that a small peptide corresponding to the C terminus of the CDK inhibitor p21 is a versatile enhancer of the cytotoxicity cause by a variety of chemotherapeutic agents. We have also identified novel enhancers of cytotoxicity in cells deficient in homologous recombination repair. Recently, we have investigated alternative tumor targets that do not involve cell killing, focusing on chromosomal instability (CIN). Our findings suggest that CIN can be mitigated under certain chemotherapeutic conditions without reducing the treatment\u2019s cytotoxic effects. This property could potentially be exploited to improve cancer therapies by preventing tumor adaptation to treatment, a major cause of therapeutic failure. These insights provide a framework for developing novel strategies that combine chemotherapy with mechanisms to stabilize chromosomes, offering promising avenues for enhancing cancer treatment outcomes.<\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-a654e8d\" id=\"strong-skills-amp-tools-strong\" data-block-id=\"a654e8d\"><style>.stk-a654e8d .stk-block-heading__text{color:var(--theme-palette-color-1, #164193) !important;}<\/style><h3 class=\"stk-block-heading__text has-text-color\"><strong>Skills &amp; tools<\/strong><\/h3><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-260d7c4\" data-block-id=\"260d7c4\"><p class=\"stk-block-text__text\">We have developed a comprehensive set of skills for analyzing DNA quality and cellular processes associated with DNA damage processing. Using alkaline and neutral comet assays, we can effectively evaluate DNA integrity, enabling precise assessments of DNA damage and repair. At the single-molecule level, we monitor DNA replication dynamics to identify defects such as altered replication speed, changes in origin firing frequency, replication fork stalling, and discontinuous DNA synthesis. These techniques allow us to study the fundamental mechanisms underlying DNA replication and its disruptions. Additionally, we have mastered methodologies to identify and quantify mitotic DNA synthesis (MiDAS) and various mitotic aberrations. These include the detection of anaphase abnormalities, such as lagging chromosomes and mitotic bridges, as well as ultrafine bridges, multinucleation, and micronuclei formation. Our work extends to characterizing 53BP1 nuclear bodies, which serve as markers of replication stress and genomic instability.<\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-5168ba6\" id=\"strong-collaboration-interests-strong\" data-block-id=\"5168ba6\"><style>.stk-5168ba6 {margin-bottom:3px !important;}.stk-5168ba6 .stk-block-heading__text{color:var(--theme-palette-color-1, #164193) !important;}<\/style><h3 class=\"stk-block-heading__text has-text-color\"><strong>Collaboration interests<\/strong><\/h3><\/div>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Sequencing of tumor samples, with a particular focus on single-cell analysis.<\/li>\n\n\n\n<li>In vivo cell microscopy with a focus on mitosis.<\/li>\n\n\n\n<li>Automated complex image analysis<\/li>\n<\/ul>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-341a9f4\" id=\"strong-selected-publications-strong\" data-block-id=\"341a9f4\"><style>.stk-341a9f4 {margin-bottom:3px !important;}.stk-341a9f4 .stk-block-heading__text{color:var(--theme-palette-color-1, #164193) !important;}<\/style><h3 class=\"stk-block-heading__text has-text-color\"><strong>Selected publications<\/strong><\/h3><\/div>\n\n\n\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-193dbfa\" data-block-id=\"193dbfa\"><style>.stk-193dbfa {padding-left:0px !important;margin-bottom:var(--stk--preset--spacing--none, 0px) !important;}.stk-193dbfa-column{--stk-column-gap:var(--stk--preset--spacing--20, 0.44rem) !important;justify-content:flex-start !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-193dbfa-column stk--flex\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-f6f2387\" data-v=\"4\" data-block-id=\"f6f2387\"><style>.stk-f6f2387 {min-height:var(--stk--preset--block-height--none, 0px) !important;max-width:1500px !important;min-width:auto !important;padding-left:var(--stk--preset--spacing--none, 0px) !important;margin-right:auto !important;margin-left:var(--stk--preset--spacing--none, 0px) !important;}@media screen and (min-width:690px){.stk-f6f2387 {flex:var(--stk-flex-grow, 1) 1 calc(82% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-f6f2387-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-f6f2387-inner-blocks\">\n<ul class=\"wp-block-list\">\n<li style=\"margin-left:0\">MARTINO, Julieta, et al. Inhibitors of Rho kinases (ROCK) induce multiple mitotic defects and synthetic lethality in BRCA2-deficient cells. Elife, 2023, vol. 12, p. e80254.<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-5a33621\" data-v=\"4\" data-block-id=\"5a33621\"><style>@media screen and (min-width:690px){.stk-5a33621 {flex:var(--stk-flex-grow, 1) 1 calc(18% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}@media screen and (max-width:689px){.stk-5a33621-container{margin-left:30px !important;}.stk-5a33621 {align-self:center !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-5a33621-container stk--no-background stk--no-padding\"><div class=\"has-text-align-left-mobile stk-block-content stk-inner-blocks stk-5a33621-inner-blocks\">\n<div class=\"wp-block-stackable-button-group stk-block-button-group stk-block stk-b873c6a\" data-block-id=\"b873c6a\"><div class=\"stk-row stk-inner-blocks stk-block-content stk-button-group\">\n<div class=\"wp-block-stackable-icon-button stk-block-icon-button stk-block stk-776b4f5\" data-block-id=\"776b4f5\"><style>.stk-776b4f5 .stk-button{background:var(--theme-palette-color-1, #164193) !important;}.stk-776b4f5 .stk-button:hover{background:var(--theme-palette-color-2, #312a74) !important;opacity:1 !important;}<\/style><a class=\"stk-link stk-button stk--hover-effect-darken\" href=\"https:\/\/elifesciences.org\/articles\/80254\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 640 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M579.8 267.7c56.5-56.5 56.5-148 0-204.5c-50-50-128.8-56.5-186.3-15.4l-1.6 1.1c-14.4 10.3-17.7 30.3-7.4 44.6s30.3 17.7 44.6 7.4l1.6-1.1c32.1-22.9 76-19.3 103.8 8.6c31.5 31.5 31.5 82.5 0 114L422.3 334.8c-31.5 31.5-82.5 31.5-114 0c-27.9-27.9-31.5-71.8-8.6-103.8l1.1-1.6c10.3-14.4 6.9-34.4-7.4-44.6s-34.4-6.9-44.6 7.4l-1.1 1.6C206.5 251.2 213 330 263 380c56.5 56.5 148 56.5 204.5 0L579.8 267.7zM60.2 244.3c-56.5 56.5-56.5 148 0 204.5c50 50 128.8 56.5 186.3 15.4l1.6-1.1c14.4-10.3 17.7-30.3 7.4-44.6s-30.3-17.7-44.6-7.4l-1.6 1.1c-32.1 22.9-76 19.3-103.8-8.6C74 372 74 321 105.5 289.5L217.7 177.2c31.5-31.5 82.5-31.5 114 0c27.9 27.9 31.5 71.8 8.6 103.9l-1.1 1.6c-10.3 14.4-6.9 34.4 7.4 44.6s34.4 6.9 44.6-7.4l1.1-1.6C433.5 260.8 427 182 377 132c-56.5-56.5-148-56.5-204.5 0L60.2 244.3z\"\/><\/svg><\/div><\/span><\/a><\/div>\n<\/div><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-divider alignfull stk-block-divider stk--hide-desktop has-text-align-center stk-block stk-94d5b9d\" data-block-id=\"94d5b9d\"><style>.stk-94d5b9d hr.stk-block-divider__hr{background:#abb8c3 !important;}@media screen and (max-width:689px){.stk-94d5b9d {align-items:center !important;margin-bottom:0px !important;display:flex !important;}}<\/style><hr class=\"stk-block-divider__hr\"\/><\/div>\n\n\n\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-5a54113\" data-block-id=\"5a54113\"><style>.stk-5a54113 {padding-left:0px !important;margin-bottom:var(--stk--preset--spacing--none, 0px) !important;}.stk-5a54113-column{--stk-column-gap:var(--stk--preset--spacing--20, 0.44rem) !important;justify-content:flex-start !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-5a54113-column stk--flex\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-4e5e1c5\" data-v=\"4\" data-block-id=\"4e5e1c5\"><style>.stk-4e5e1c5 {min-height:var(--stk--preset--block-height--none, 0px) !important;max-width:1500px !important;min-width:auto !important;padding-left:var(--stk--preset--spacing--none, 0px) !important;margin-right:auto !important;margin-left:var(--stk--preset--spacing--none, 0px) !important;}@media screen and (min-width:690px){.stk-4e5e1c5 {flex:var(--stk-flex-grow, 1) 1 calc(82% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-4e5e1c5-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-4e5e1c5-inner-blocks\">\n<ul class=\"wp-block-list\">\n<li style=\"margin-left:0\">MANSILLA, Sabrina F., et al. Polymerase iota (Pol\u03b9) prevents PrimPol-mediated nascent DNA synthesis and chromosome instability. Science Advances, 2023, vol. 9, no 15, p. eade7997.<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-ef8479e\" data-v=\"4\" data-block-id=\"ef8479e\"><style>@media screen and (min-width:690px){.stk-ef8479e {flex:var(--stk-flex-grow, 1) 1 calc(18% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}@media screen and (max-width:689px){.stk-ef8479e-container{margin-left:30px !important;}.stk-ef8479e {align-self:center !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-ef8479e-container stk--no-background stk--no-padding\"><div class=\"has-text-align-left-mobile stk-block-content stk-inner-blocks stk-ef8479e-inner-blocks\">\n<div class=\"wp-block-stackable-button-group stk-block-button-group stk-block stk-98399e6\" data-block-id=\"98399e6\"><div class=\"stk-row stk-inner-blocks stk-block-content stk-button-group\">\n<div class=\"wp-block-stackable-icon-button stk-block-icon-button stk-block stk-edb2ba1\" data-block-id=\"edb2ba1\"><style>.stk-edb2ba1 .stk-button{background:var(--theme-palette-color-1, #164193) !important;}.stk-edb2ba1 .stk-button:hover{background:var(--theme-palette-color-2, #312a74) !important;opacity:1 !important;}<\/style><a class=\"stk-link stk-button stk--hover-effect-darken\" href=\"https:\/\/www.science.org\/doi\/abs\/10.1126\/sciadv.ade7997\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 640 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M579.8 267.7c56.5-56.5 56.5-148 0-204.5c-50-50-128.8-56.5-186.3-15.4l-1.6 1.1c-14.4 10.3-17.7 30.3-7.4 44.6s30.3 17.7 44.6 7.4l1.6-1.1c32.1-22.9 76-19.3 103.8 8.6c31.5 31.5 31.5 82.5 0 114L422.3 334.8c-31.5 31.5-82.5 31.5-114 0c-27.9-27.9-31.5-71.8-8.6-103.8l1.1-1.6c10.3-14.4 6.9-34.4-7.4-44.6s-34.4-6.9-44.6 7.4l-1.1 1.6C206.5 251.2 213 330 263 380c56.5 56.5 148 56.5 204.5 0L579.8 267.7zM60.2 244.3c-56.5 56.5-56.5 148 0 204.5c50 50 128.8 56.5 186.3 15.4l1.6-1.1c14.4-10.3 17.7-30.3 7.4-44.6s-30.3-17.7-44.6-7.4l-1.6 1.1c-32.1 22.9-76 19.3-103.8-8.6C74 372 74 321 105.5 289.5L217.7 177.2c31.5-31.5 82.5-31.5 114 0c27.9 27.9 31.5 71.8 8.6 103.9l-1.1 1.6c-10.3 14.4-6.9 34.4 7.4 44.6s34.4 6.9 44.6-7.4l1.1-1.6C433.5 260.8 427 182 377 132c-56.5-56.5-148-56.5-204.5 0L60.2 244.3z\"\/><\/svg><\/div><\/span><\/a><\/div>\n<\/div><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-divider alignfull stk-block-divider stk--hide-desktop has-text-align-center stk-block stk-af78abf\" data-block-id=\"af78abf\"><style>.stk-af78abf hr.stk-block-divider__hr{background:#abb8c3 !important;}@media screen and (max-width:689px){.stk-af78abf {align-items:center !important;margin-bottom:0px !important;display:flex !important;}}<\/style><hr class=\"stk-block-divider__hr\"\/><\/div>\n\n\n\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-2cc98fc\" data-block-id=\"2cc98fc\"><style>.stk-2cc98fc {padding-left:0px !important;margin-bottom:var(--stk--preset--spacing--none, 0px) !important;}.stk-2cc98fc-column{--stk-column-gap:var(--stk--preset--spacing--20, 0.44rem) !important;justify-content:flex-start !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-2cc98fc-column stk--flex\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-2d73e22\" data-v=\"4\" data-block-id=\"2d73e22\"><style>.stk-2d73e22 {min-height:var(--stk--preset--block-height--none, 0px) !important;max-width:1500px !important;min-width:auto !important;padding-left:var(--stk--preset--spacing--none, 0px) !important;margin-right:auto !important;margin-left:var(--stk--preset--spacing--none, 0px) !important;}@media screen and (min-width:690px){.stk-2d73e22 {flex:var(--stk-flex-grow, 1) 1 calc(82% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-2d73e22-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-2d73e22-inner-blocks\">\n<ul class=\"wp-block-list\">\n<li style=\"margin-left:0\">CALZETTA, Nicol\u00e1s Luis; GONZ\u00c1LEZ BESTEIRO, Marina Alejandra; GOTTIFREDI, Vanesa. Mus81-Eme1\u2013dependent aberrant processing of DNA replication intermediates in mitosis impairs genome integrity. Science Advances, 2020, vol. 6, no 50, p. eabc8257.<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-7f13117\" data-v=\"4\" data-block-id=\"7f13117\"><style>@media screen and (min-width:690px){.stk-7f13117 {flex:var(--stk-flex-grow, 1) 1 calc(18% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}@media screen and (max-width:689px){.stk-7f13117-container{margin-left:30px !important;}.stk-7f13117 {align-self:center !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-7f13117-container stk--no-background stk--no-padding\"><div class=\"has-text-align-left-mobile stk-block-content stk-inner-blocks stk-7f13117-inner-blocks\">\n<div class=\"wp-block-stackable-button-group stk-block-button-group stk-block stk-d13ba5c\" data-block-id=\"d13ba5c\"><div class=\"stk-row stk-inner-blocks stk-block-content stk-button-group\">\n<div class=\"wp-block-stackable-icon-button stk-block-icon-button stk-block stk-043b817\" data-block-id=\"043b817\"><style>.stk-043b817 .stk-button{background:var(--theme-palette-color-1, #164193) !important;}.stk-043b817 .stk-button:hover{background:var(--theme-palette-color-2, #312a74) !important;opacity:1 !important;}<\/style><a class=\"stk-link stk-button stk--hover-effect-darken\" href=\"https:\/\/www.science.org\/doi\/abs\/10.1126\/sciadv.abc8257\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 640 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M579.8 267.7c56.5-56.5 56.5-148 0-204.5c-50-50-128.8-56.5-186.3-15.4l-1.6 1.1c-14.4 10.3-17.7 30.3-7.4 44.6s30.3 17.7 44.6 7.4l1.6-1.1c32.1-22.9 76-19.3 103.8 8.6c31.5 31.5 31.5 82.5 0 114L422.3 334.8c-31.5 31.5-82.5 31.5-114 0c-27.9-27.9-31.5-71.8-8.6-103.8l1.1-1.6c10.3-14.4 6.9-34.4-7.4-44.6s-34.4-6.9-44.6 7.4l-1.1 1.6C206.5 251.2 213 330 263 380c56.5 56.5 148 56.5 204.5 0L579.8 267.7zM60.2 244.3c-56.5 56.5-56.5 148 0 204.5c50 50 128.8 56.5 186.3 15.4l1.6-1.1c14.4-10.3 17.7-30.3 7.4-44.6s-30.3-17.7-44.6-7.4l-1.6 1.1c-32.1 22.9-76 19.3-103.8-8.6C74 372 74 321 105.5 289.5L217.7 177.2c31.5-31.5 82.5-31.5 114 0c27.9 27.9 31.5 71.8 8.6 103.9l-1.1 1.6c-10.3 14.4-6.9 34.4 7.4 44.6s34.4 6.9 44.6-7.4l1.1-1.6C433.5 260.8 427 182 377 132c-56.5-56.5-148-56.5-204.5 0L60.2 244.3z\"\/><\/svg><\/div><\/span><\/a><\/div>\n<\/div><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-divider alignfull stk-block-divider stk--hide-desktop has-text-align-center stk-block stk-91225dd\" data-block-id=\"91225dd\"><style>.stk-91225dd hr.stk-block-divider__hr{background:#abb8c3 !important;}@media screen and (max-width:689px){.stk-91225dd {align-items:center !important;margin-bottom:0px !important;display:flex !important;}}<\/style><hr class=\"stk-block-divider__hr\"\/><\/div>\n\n\n\n<div class=\"wp-block-stackable-spacer stk-block-spacer stk--no-padding stk-block stk-9f3d337\" data-block-id=\"9f3d337\"><style>.stk-9f3d337 {height:30px !important;}<\/style><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-greenshift-blocks-row-column gspb_row__col--3 gspb_col-id-gsbp-6a5e99e\" id=\"gspb_col-id-gsbp-6a5e99e\">\n<div class=\"wp-block-stackable-image stk-block-image stk-block stk-30062fb\" data-block-id=\"30062fb\"><style>.stk-30062fb .stk-img-wrapper{width:80% !important;}<\/style><figure><span class=\"stk-img-wrapper stk-image--shape-stretch\"><img loading=\"lazy\" decoding=\"async\" class=\"stk-img wp-image-1152\" src=\"https:\/\/www.leloir.org.ar\/research\/wp-content\/uploads\/2026\/06\/Fil__Gottifredi.png\" width=\"400\" height=\"400\" srcset=\"https:\/\/www.leloir.org.ar\/research\/wp-content\/uploads\/2026\/06\/Fil__Gottifredi.png 400w, https:\/\/www.leloir.org.ar\/research\/wp-content\/uploads\/2026\/06\/Fil__Gottifredi-300x300.png 300w, https:\/\/www.leloir.org.ar\/research\/wp-content\/uploads\/2026\/06\/Fil__Gottifredi-150x150.png 150w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/span><\/figure><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-2075d5d\" data-block-id=\"2075d5d\"><style>.stk-2075d5d {margin-bottom:0px !important;}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #ffffff;\" class=\"stk-highlight\">Principal investigator<\/span><\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-b752a64\" id=\"vanesa-gottifred-ph-d\" data-block-id=\"b752a64\"><style>.stk-b752a64 .stk-block-heading__text{line-height:1.2em !important;}<\/style><h4 class=\"stk-block-heading__text\">Vanesa Gottifred, PhD<\/h4><\/div>\n\n\n\n<div class=\"wp-block-stackable-icon-label stk-block-icon-label stk-block stk-b51f5e0\" data-block-id=\"b51f5e0\"><style>.stk-b51f5e0 .stk-inner-blocks{gap:10px !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content\">\n<div class=\"wp-block-stackable-icon stk-block-icon has-text-align-left stk-block stk-e43d088\" data-block-id=\"e43d088\"><style>.stk-e43d088 .stk--svg-wrapper .stk--inner-svg svg:last-child{height:22px !important;width:22px !important;}.stk-e43d088 .stk--svg-wrapper .stk--inner-svg svg:last-child, .stk-e43d088 .stk--svg-wrapper .stk--inner-svg svg:last-child :is(g, path, rect, polygon, ellipse){fill:var(--theme-palette-color-5, #35b6b4) !important;}<\/style><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg style=\"height:0;width:0\"><defs><linearGradient id=\"linear-gradient-e43d088\" x1=\"0\" x2=\"100%\" y1=\"0\" y2=\"0\"><stop offset=\"0%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-e-43-d-088-color-1)\"><\/stop><stop offset=\"100%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-e-43-d-088-color-2)\"><\/stop><\/linearGradient><\/defs><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M64 112c-8.8 0-16 7.2-16 16v22.1L220.5 291.7c20.7 17 50.4 17 71.1 0L464 150.1V128c0-8.8-7.2-16-16-16H64zM48 212.2V384c0 8.8 7.2 16 16 16H448c8.8 0 16-7.2 16-16V212.2L322 328.8c-38.4 31.5-93.7 31.5-132 0L48 212.2zM0 128C0 92.7 28.7 64 64 64H448c35.3 0 64 28.7 64 64V384c0 35.3-28.7 64-64 64H64c-35.3 0-64-28.7-64-64V128z\"\/><\/svg><\/div><\/span><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-09109d8\" id=\"strong-vgottifredi-leloir-org-ar-strong\" data-block-id=\"09109d8\"><style>.stk-09109d8 .stk-block-heading__text{font-size:1.2rem !important;color:var(--theme-palette-color-5, #35b6b4) !important;}@media screen and (max-width:999px){.stk-09109d8 .stk-block-heading__text{font-size:1.2rem !important;}}<\/style><p class=\"stk-block-heading__text has-text-color\"><strong>vgottifredi@leloir.org.ar<\/strong><\/p><\/div>\n<\/div><\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-11caa78\" data-block-id=\"11caa78\"><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-11caa78-column\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-5123533\" data-v=\"4\" data-block-id=\"5123533\"><style>@media screen and (min-width:690px){.stk-5123533 {flex:var(--stk-flex-grow, 1) 1 calc(20% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-5123533-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-5123533-inner-blocks\">\n<div class=\"wp-block-stackable-icon stk-block-icon stk-block stk-6a46513\" data-block-id=\"6a46513\"><style>.stk-6a46513 .stk--svg-wrapper .stk--inner-svg svg:last-child{height:18px !important;width:18px !important;}.stk-6a46513 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17-7l33.3-33.3c16.9 5.4 35 8.3 53.7 8.3zM376 96a40 40 0 1 1 0 80 40 40 0 1 1 0-80z\"\/><\/svg><\/div><\/span><\/div>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-566cc73\" data-v=\"4\" data-block-id=\"566cc73\"><style>@media screen and (min-width:690px){.stk-566cc73 {flex:var(--stk-flex-grow, 1) 1 calc(80% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-566cc73-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-566cc73-inner-blocks\">\n<ul style=\"padding-right:0;padding-left:0\" class=\"wp-block-list\">\n<li class=\"has-palette-color-3-color has-text-color has-link-color wp-elements-cb60078f7ec8fdd3f1aae854e86e39c0\" style=\"line-height:1.3\">DNA replication stress<br><\/li>\n\n\n\n<li class=\"has-palette-color-3-color has-text-color has-link-color wp-elements-d87b13f1af1b5bd2aedc96580d36b56f\" style=\"line-height:1.3\">chromosomal instability<br><\/li>\n\n\n\n<li class=\"has-palette-color-3-color has-text-color has-link-color wp-elements-626070dd0b047f05fc19eb1d43587b17\" style=\"line-height:1.3\">cancer therapy<br><\/li>\n\n\n\n<li class=\"has-palette-color-3-color has-text-color has-link-color wp-elements-d669d25fe7f170e024b20922f48efa64\" style=\"line-height:1.3\">homologous recombination<br><\/li>\n\n\n\n<li class=\"has-palette-color-3-color has-text-color has-link-color wp-elements-c914e9d691dc8da96824d206e9bcf3fb\" style=\"line-height:1.3\">genomic stability<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n<\/div><\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Research area 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