{"id":1134,"date":"2026-06-24T17:35:14","date_gmt":"2026-06-24T20:35:14","guid":{"rendered":"https:\/\/www.leloir.org.ar\/research\/?page_id=1134"},"modified":"2026-07-07T11:07:25","modified_gmt":"2026-07-07T14:07:25","slug":"molecular-physiology-and-genetics","status":"publish","type":"page","link":"https:\/\/www.leloir.org.ar\/research\/molecular-physiology-and-genetics\/","title":{"rendered":"molecular physiology and genetics"},"content":{"rendered":"\n<div class=\"wp-block-stackable-spacer stk-block-spacer stk--no-padding stk-block stk-c50c6d5\" data-block-id=\"c50c6d5\"><style>.stk-c50c6d5 {height:20px !important;}<\/style><\/div>\n\n\n\n<div class=\"wp-block-stackable-columns alignfull stk-block-columns stk--hide-mobile stk-block stk-efbfbbe\" data-block-id=\"efbfbbe\"><style>.stk-efbfbbe {margin-bottom:0px !important;top:0px !important;left:0px !important;}.stk-efbfbbe-column{max-width:80% !important;min-width:auto !important;margin-right:auto !important;margin-left:0px !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-efbfbbe-column alignfull\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-095be29 stk-block-background\" data-v=\"4\" data-block-id=\"095be29\"><style>.stk-095be29-container{margin-top:var(--stk--preset--spacing--none, 0px) !important;margin-right:var(--stk--preset--spacing--none, 0px) !important;margin-bottom:var(--stk--preset--spacing--none, 0px) !important;margin-left:var(--stk--preset--spacing--none, 0px) !important;min-height:var(--stk--preset--block-height--none, 0px) !important;}.stk-095be29 {align-self:center !important;background-color:var(--theme-palette-color-1, #164193) !important;border-top-right-radius:var(--stk--preset--border-radius--full, 9999px) !important;border-bottom-right-radius:var(--stk--preset--border-radius--full, 9999px) !important;border-bottom-left-radius:var(--stk--preset--border-radius--none, 0px) !important;overflow:hidden !important;min-height:var(--stk--preset--block-height--none, 0px) !important;align-items:center !important;max-width:500px !important;min-width:auto !important;padding-top:var(--stk--preset--spacing--none, 0px) !important;padding-bottom:var(--stk--preset--spacing--none, 0px) !important;padding-left:60px !important;margin-top:var(--stk--preset--spacing--none, 0px) !important;margin-left:0px !important;display:flex !important;}.stk-095be29:before{background-color:var(--theme-palette-color-1, #164193) !important;}@media screen and (min-width:690px){.stk-095be29 {flex:var(--stk-flex-grow, 1) 1 calc(56% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-095be29-container stk--no-background stk--no-padding\"><div class=\"has-text-align-left stk--block-horizontal-flex stk-block-content stk-inner-blocks stk-095be29-inner-blocks\">\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-a3b5388\" data-block-id=\"a3b5388\"><style>.stk-a3b5388 {padding-top:var(--stk--preset--spacing--none, 0px) !important;padding-right:0px !important;padding-bottom:var(--stk--preset--spacing--none, 0px) !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-a3b5388-column\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-ec743fe\" data-v=\"4\" data-block-id=\"ec743fe\"><style>.stk-ec743fe {padding-left:var(--stk--preset--spacing--none, 0px) !important;margin-right:var(--stk--preset--spacing--none, 0px) !important;margin-left:var(--stk--preset--spacing--none, 0px) !important;}.stk-ec743fe-container{padding-left:var(--stk--preset--spacing--none, 0px) !important;}@media screen and (min-width:690px){.stk-ec743fe {flex:var(--stk-flex-grow, 1) 1 calc(81.1% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-ec743fe-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-ec743fe-inner-blocks\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-0108191\" id=\"strong-research-area-strong\" data-block-id=\"0108191\"><style>.stk-0108191 {margin-bottom:0px !important;}.stk-0108191 .stk-block-heading__text{color:var(--theme-palette-color-3, #a7a04d) !important;}<\/style><h6 class=\"stk-block-heading__text has-text-color\"><strong>Research area<\/strong><\/h6><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-0b4b126\" id=\"strong-cell-and-developmental-biology-strong\" data-block-id=\"0b4b126\"><style>.stk-0b4b126 {align-items:flex-start !important;padding-top:var(--stk--preset--spacing--none, 0px) !important;padding-bottom:var(--stk--preset--spacing--none, 0px) !important;margin-top:var(--stk--preset--spacing--none, 0px) !important;margin-bottom:var(--stk--preset--spacing--none, 0px) !important;margin-left:var(--stk--preset--spacing--none, 0px) !important;display:flex !important;}<\/style><h5 class=\"stk-block-heading__text\"><strong>Cell and developmental biology<\/strong><\/h5><\/div>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-4110096\" data-v=\"4\" data-block-id=\"4110096\"><style>.stk-4110096 {align-self:center !important;padding-top:var(--stk--preset--spacing--none, 0px) !important;padding-right:var(--stk--preset--spacing--none, 0px) !important;padding-bottom:var(--stk--preset--spacing--none, 0px) !important;padding-left:var(--stk--preset--spacing--none, 0px) !important;margin-right:var(--stk--preset--spacing--none, 0px) !important;}.stk-4110096-inner-blocks{align-items:center !important;}@media screen and (min-width:690px){.stk-4110096 {flex:var(--stk-flex-grow, 1) 1 calc(18.9% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-4110096-container stk--no-background stk--no-padding\"><div class=\"stk--block-horizontal-flex stk--column-flex stk-block-content stk-inner-blocks stk-4110096-inner-blocks\">\n<div class=\"wp-block-stackable-image stk-block-image stk-block stk-5f46d71\" data-block-id=\"5f46d71\"><style>.stk-5f46d71 .stk-img-wrapper{width:100% !important;}<\/style><figure><span class=\"stk-img-wrapper stk-image--shape-stretch\"><img loading=\"lazy\" decoding=\"async\" class=\"stk-img wp-image-1050\" src=\"https:\/\/www.leloir.org.ar\/research\/wp-content\/uploads\/2026\/05\/Fil_web-ingles-03.png\" width=\"100\" height=\"100\"\/><\/span><\/figure><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-9284d94\" data-v=\"4\" data-block-id=\"9284d94\"><style>@media screen and (min-width:690px){.stk-9284d94 {flex:var(--stk-flex-grow, 1) 1 calc(44% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-9284d94-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-9284d94-inner-blocks\"><\/div><\/div><\/div>\n<\/div><\/div>\n\n\n<style><\/style><style><\/style>\n<div class=\"wp-block-greenshift-blocks-container alignfull gspb_container gspb_container-gsbp-c15c419\" id=\"gspb_container-id-gsbp-c15c419\">\n<div class=\"wp-block-greenshift-blocks-row gspb_row gspb_row-id-gsbp-18a8bbc\" id=\"gspb_row-id-gsbp-18a8bbc\"><div class=\"gspb_row__content\"> \n<div class=\"wp-block-greenshift-blocks-row-column gspb_row__col--6 gspb_row__col--xs-9 gspb_col-id-gsbp-1de9e8b\" id=\"gspb_col-id-gsbp-1de9e8b\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-fe81fce\" id=\"strong-research-area-strong\" data-block-id=\"fe81fce\"><style>.stk-fe81fce .stk-block-heading__text{color:var(--theme-palette-color-3, #a7a04d) !important;}@media screen and (max-width:689px){.stk-fe81fce {padding-bottom:0px !important;margin-bottom:0px !important;}}<\/style><h6 class=\"stk-block-heading__text has-text-color\"><strong>Research area<\/strong><\/h6><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-f5d6339\" id=\"strong-research-area-strong\" data-block-id=\"f5d6339\"><style>@media screen and (max-width:689px){.stk-f5d6339 {align-items:flex-start !important;padding-top:0px !important;padding-right:0px !important;padding-bottom:0px !important;padding-left:0px !important;margin-bottom:0px !important;display:flex !important;}}<\/style><h5 class=\"stk-block-heading__text has-text-align-left-mobile\"><strong>Cell and developmental biology<\/strong><\/h5><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-greenshift-blocks-row-column gspb_row__col--6 gspb_row__col--xs-3 gspb_col-id-gsbp-643144c\" id=\"gspb_col-id-gsbp-643144c\">\n<div class=\"wp-block-stackable-image stk-block-image stk-block stk-aaae08c\" data-block-id=\"aaae08c\"><style>@media screen and (max-width:689px){.stk-aaae08c .stk-img-wrapper{width:80% !important;}}<\/style><figure><span class=\"stk-img-wrapper stk-image--shape-stretch\"><img loading=\"lazy\" decoding=\"async\" class=\"stk-img wp-image-1050\" src=\"https:\/\/www.leloir.org.ar\/research\/wp-content\/uploads\/2026\/05\/Fil_web-ingles-03.png\" width=\"100\" height=\"100\"\/><\/span><\/figure><\/div>\n<\/div>\n <\/div><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-stackable-spacer stk-block-spacer stk--no-padding stk-block stk-98a4aa9\" data-block-id=\"98a4aa9\"><style>.stk-98a4aa9 {height:30px !important;}<\/style><\/div>\n\n\n\n<div class=\"wp-block-greenshift-blocks-row alignwide gspb_row gspb_row-id-gsbp-22b4991 gspb_row--gutter-20\" id=\"gspb_row-id-gsbp-22b4991\">\n<div class=\"wp-block-greenshift-blocks-row-column gspb_row__col--9 gspb_col-id-gsbp-c9b3f6b\" id=\"gspb_col-id-gsbp-c9b3f6b\">\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-104d4ac\" id=\"molecular-physiology-and-genetics\" data-block-id=\"104d4ac\"><style>.stk-104d4ac {margin-bottom:40px !important;}.stk-104d4ac .stk-block-heading__text{color:var(--theme-palette-color-3, #a7a04d) !important;}<\/style><h2 class=\"stk-block-heading__text has-text-color\">MOLECULAR PHYSIOLOGY AND GENETICS<\/h2><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-41b44af\" id=\"strong-research-strong\" data-block-id=\"41b44af\"><style>.stk-41b44af .stk-block-heading__text{color:var(--theme-palette-color-1, #164193) !important;}<\/style><h3 class=\"stk-block-heading__text has-text-color\"><strong>Research<\/strong><\/h3><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-bf578d0\" data-block-id=\"bf578d0\"><p class=\"stk-block-text__text\">Our group is interested on the cellular mechanisms that mediate adaptation to stress conditions, and to this end, utilizes the unique genetic tools available in fruit fly Drosophila melanogaster. Cells can adapt to adverse environmental situations by altering their gene expression profile, and by mounting a wide array of physiological responses that enable restoration of homeostasis. In this context, our research focuses on the role of autophagy, intracellular vesicle trafficking and transcriptional responses to hypoxia during developmental processes. Specifically, we are studying the role of autophagy in cell differentiation during hematopoiesis in fly larvae, and how the different signaling pathways involved are regulated by autophagy. We are particularly interested on the relationship between autophagy and vesicular dynamics during endocytosis, exocytosis and lysosomal degradation. We intend to understand how these subcellular machineries interplay with each other to regulate intracellular signaling and thereby, cell differentiation during development.<\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-bef9c0d\" id=\"strong-skills-amp-tools-strong\" data-block-id=\"bef9c0d\"><style>.stk-bef9c0d .stk-block-heading__text{color:var(--theme-palette-color-1, #164193) !important;}<\/style><h3 class=\"stk-block-heading__text has-text-color\"><strong>Skills &amp; tools<\/strong><\/h3><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-6f973a4\" data-block-id=\"6f973a4\"><p class=\"stk-block-text__text\">We are Drosophila geneticists that utilize a broad spectrum of gene manipulation techniques in vivo. These include generation and utilization of fly mutant strains, as well as of transgenic fly lines that express genetic elements of interest, such as interference (double-stranded) RNAs, proteins fused to fluorophores and dominant negative constructs among others. The readout of most of our experiments<br>involve immunofluorescent detection of molecules of interest, followed by observation under a confocal microscope. Thus, we have expertise in acquisition and analysis of both single-plane and Z-stack images of diverse organelles and other subcellular structures. Our samples include whole mount embryos, larval or adult organs, as well as dissected tissues in still images or timelapse microscopy during dynamic biological processes.<\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-8fb662c\" id=\"strong-collaboration-interests-strong\" data-block-id=\"8fb662c\"><style>.stk-8fb662c {margin-bottom:3px !important;}.stk-8fb662c .stk-block-heading__text{color:var(--theme-palette-color-1, #164193) !important;}<\/style><h3 class=\"stk-block-heading__text has-text-color\"><strong>Collaboration interests<\/strong><\/h3><\/div>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Electron microscopy<\/li>\n\n\n\n<li>Metabolomics<\/li>\n\n\n\n<li>Protein structure and biochemistry<\/li>\n\n\n\n<li>Genetic screens<\/li>\n<\/ul>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-fb4e260\" id=\"strong-selected-publications-strong\" data-block-id=\"fb4e260\"><style>.stk-fb4e260 {margin-bottom:3px !important;}.stk-fb4e260 .stk-block-heading__text{color:var(--theme-palette-color-1, #164193) !important;}<\/style><h3 class=\"stk-block-heading__text has-text-color\"><strong>Selected publications<\/strong><\/h3><\/div>\n\n\n\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-6b0f0e9\" data-block-id=\"6b0f0e9\"><style>.stk-6b0f0e9 {padding-left:0px !important;margin-bottom:var(--stk--preset--spacing--none, 0px) !important;}.stk-6b0f0e9-column{--stk-column-gap:var(--stk--preset--spacing--20, 0.44rem) !important;justify-content:flex-start !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-6b0f0e9-column stk--flex\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-051e83d\" data-v=\"4\" data-block-id=\"051e83d\"><style>.stk-051e83d {min-height:var(--stk--preset--block-height--none, 0px) !important;max-width:1500px !important;min-width:auto !important;padding-left:var(--stk--preset--spacing--none, 0px) !important;margin-right:auto !important;margin-left:var(--stk--preset--spacing--none, 0px) !important;}@media screen and (min-width:690px){.stk-051e83d {flex:var(--stk-flex-grow, 1) 1 calc(82% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-051e83d-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-051e83d-inner-blocks\">\n<ul class=\"wp-block-list\">\n<li style=\"margin-left:0\">WAPPNER, Pablo, et al. Autophagy controls differentiation of Drosophila blood cells by regulating Notch levels in response to nutrient availability. 2024.<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-3edd196\" data-v=\"4\" data-block-id=\"3edd196\"><style>@media screen and (min-width:690px){.stk-3edd196 {flex:var(--stk-flex-grow, 1) 1 calc(18% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}@media screen and (max-width:689px){.stk-3edd196-container{margin-left:30px !important;}.stk-3edd196 {align-self:center !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-3edd196-container stk--no-background stk--no-padding\"><div class=\"has-text-align-left-mobile stk-block-content stk-inner-blocks stk-3edd196-inner-blocks\">\n<div class=\"wp-block-stackable-button-group stk-block-button-group stk-block stk-12c0695\" data-block-id=\"12c0695\"><div class=\"stk-row stk-inner-blocks stk-block-content stk-button-group\">\n<div class=\"wp-block-stackable-icon-button stk-block-icon-button stk-block stk-5f4831a\" data-block-id=\"5f4831a\"><style>.stk-5f4831a .stk-button{background:var(--theme-palette-color-1, #164193) !important;}.stk-5f4831a .stk-button:hover{background:var(--theme-palette-color-2, #312a74) !important;opacity:1 !important;}<\/style><a class=\"stk-link stk-button stk--hover-effect-darken\" href=\"https:\/\/www.researchsquare.com\/article\/rs-4707838\/latest\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 640 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M579.8 267.7c56.5-56.5 56.5-148 0-204.5c-50-50-128.8-56.5-186.3-15.4l-1.6 1.1c-14.4 10.3-17.7 30.3-7.4 44.6s30.3 17.7 44.6 7.4l1.6-1.1c32.1-22.9 76-19.3 103.8 8.6c31.5 31.5 31.5 82.5 0 114L422.3 334.8c-31.5 31.5-82.5 31.5-114 0c-27.9-27.9-31.5-71.8-8.6-103.8l1.1-1.6c10.3-14.4 6.9-34.4-7.4-44.6s-34.4-6.9-44.6 7.4l-1.1 1.6C206.5 251.2 213 330 263 380c56.5 56.5 148 56.5 204.5 0L579.8 267.7zM60.2 244.3c-56.5 56.5-56.5 148 0 204.5c50 50 128.8 56.5 186.3 15.4l1.6-1.1c14.4-10.3 17.7-30.3 7.4-44.6s-30.3-17.7-44.6-7.4l-1.6 1.1c-32.1 22.9-76 19.3-103.8-8.6C74 372 74 321 105.5 289.5L217.7 177.2c31.5-31.5 82.5-31.5 114 0c27.9 27.9 31.5 71.8 8.6 103.9l-1.1 1.6c-10.3 14.4-6.9 34.4 7.4 44.6s34.4 6.9 44.6-7.4l1.1-1.6C433.5 260.8 427 182 377 132c-56.5-56.5-148-56.5-204.5 0L60.2 244.3z\"\/><\/svg><\/div><\/span><\/a><\/div>\n<\/div><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-divider alignfull stk-block-divider stk--hide-desktop has-text-align-center stk-block stk-45e2b15\" data-block-id=\"45e2b15\"><style>.stk-45e2b15 hr.stk-block-divider__hr{background:#abb8c3 !important;}@media screen and (max-width:689px){.stk-45e2b15 {align-items:center !important;margin-bottom:0px !important;display:flex !important;}}<\/style><hr class=\"stk-block-divider__hr\"\/><\/div>\n\n\n\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-bf15457\" data-block-id=\"bf15457\"><style>.stk-bf15457 {padding-left:0px !important;margin-bottom:var(--stk--preset--spacing--none, 0px) !important;}.stk-bf15457-column{--stk-column-gap:var(--stk--preset--spacing--20, 0.44rem) !important;justify-content:flex-start !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-bf15457-column stk--flex\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-82616a0\" data-v=\"4\" data-block-id=\"82616a0\"><style>.stk-82616a0 {min-height:var(--stk--preset--block-height--none, 0px) !important;max-width:1500px !important;min-width:auto !important;padding-left:var(--stk--preset--spacing--none, 0px) !important;margin-right:auto !important;margin-left:var(--stk--preset--spacing--none, 0px) !important;}@media screen and (min-width:690px){.stk-82616a0 {flex:var(--stk-flex-grow, 1) 1 calc(82% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-82616a0-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-82616a0-inner-blocks\">\n<ul class=\"wp-block-list\">\n<li style=\"margin-left:0\">FREIRE, Sof\u00eda Su\u00e1rez, et al. The exocyst complex controls multiple events in the pathway of regulated exocytosis. Elife, 2024, vol. 12, p. RP92404.<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-8f43baf\" data-v=\"4\" data-block-id=\"8f43baf\"><style>@media screen and (min-width:690px){.stk-8f43baf {flex:var(--stk-flex-grow, 1) 1 calc(18% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}@media screen and (max-width:689px){.stk-8f43baf-container{margin-left:30px !important;}.stk-8f43baf {align-self:center !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-8f43baf-container stk--no-background stk--no-padding\"><div class=\"has-text-align-left-mobile stk-block-content stk-inner-blocks stk-8f43baf-inner-blocks\">\n<div class=\"wp-block-stackable-button-group stk-block-button-group stk-block stk-361a94b\" data-block-id=\"361a94b\"><div class=\"stk-row stk-inner-blocks stk-block-content stk-button-group\">\n<div class=\"wp-block-stackable-icon-button stk-block-icon-button stk-block stk-b97f828\" data-block-id=\"b97f828\"><style>.stk-b97f828 .stk-button{background:var(--theme-palette-color-1, #164193) !important;}.stk-b97f828 .stk-button:hover{background:var(--theme-palette-color-2, #312a74) !important;opacity:1 !important;}<\/style><a class=\"stk-link stk-button stk--hover-effect-darken\" href=\"https:\/\/elifesciences.org\/articles\/92404\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 640 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M579.8 267.7c56.5-56.5 56.5-148 0-204.5c-50-50-128.8-56.5-186.3-15.4l-1.6 1.1c-14.4 10.3-17.7 30.3-7.4 44.6s30.3 17.7 44.6 7.4l1.6-1.1c32.1-22.9 76-19.3 103.8 8.6c31.5 31.5 31.5 82.5 0 114L422.3 334.8c-31.5 31.5-82.5 31.5-114 0c-27.9-27.9-31.5-71.8-8.6-103.8l1.1-1.6c10.3-14.4 6.9-34.4-7.4-44.6s-34.4-6.9-44.6 7.4l-1.1 1.6C206.5 251.2 213 330 263 380c56.5 56.5 148 56.5 204.5 0L579.8 267.7zM60.2 244.3c-56.5 56.5-56.5 148 0 204.5c50 50 128.8 56.5 186.3 15.4l1.6-1.1c14.4-10.3 17.7-30.3 7.4-44.6s-30.3-17.7-44.6-7.4l-1.6 1.1c-32.1 22.9-76 19.3-103.8-8.6C74 372 74 321 105.5 289.5L217.7 177.2c31.5-31.5 82.5-31.5 114 0c27.9 27.9 31.5 71.8 8.6 103.9l-1.1 1.6c-10.3 14.4-6.9 34.4 7.4 44.6s34.4 6.9 44.6-7.4l1.1-1.6C433.5 260.8 427 182 377 132c-56.5-56.5-148-56.5-204.5 0L60.2 244.3z\"\/><\/svg><\/div><\/span><\/a><\/div>\n<\/div><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-divider alignfull stk-block-divider stk--hide-desktop has-text-align-center stk-block stk-759973f\" data-block-id=\"759973f\"><style>.stk-759973f hr.stk-block-divider__hr{background:#abb8c3 !important;}@media screen and (max-width:689px){.stk-759973f {align-items:center !important;margin-bottom:0px !important;display:flex !important;}}<\/style><hr class=\"stk-block-divider__hr\"\/><\/div>\n\n\n\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-a2d56a6\" data-block-id=\"a2d56a6\"><style>.stk-a2d56a6 {padding-left:0px !important;margin-bottom:var(--stk--preset--spacing--none, 0px) !important;}.stk-a2d56a6-column{--stk-column-gap:var(--stk--preset--spacing--20, 0.44rem) !important;justify-content:flex-start !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-a2d56a6-column stk--flex\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-4b33d14\" data-v=\"4\" data-block-id=\"4b33d14\"><style>.stk-4b33d14 {min-height:var(--stk--preset--block-height--none, 0px) !important;max-width:1500px !important;min-width:auto !important;padding-left:var(--stk--preset--spacing--none, 0px) !important;margin-right:auto !important;margin-left:var(--stk--preset--spacing--none, 0px) !important;}@media screen and (min-width:690px){.stk-4b33d14 {flex:var(--stk-flex-grow, 1) 1 calc(82% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-4b33d14-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-4b33d14-inner-blocks\">\n<ul class=\"wp-block-list\">\n<li style=\"margin-left:0\">VALKO, Ayel\u00e9n, et al. Adaptation to hypoxia in Drosophila melanogaster requires autophagy. Autophagy, 2022, vol. 18, no 4, p. 909-920<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-84af16c\" data-v=\"4\" data-block-id=\"84af16c\"><style>@media screen and (min-width:690px){.stk-84af16c {flex:var(--stk-flex-grow, 1) 1 calc(18% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}@media screen and (max-width:689px){.stk-84af16c-container{margin-left:30px !important;}.stk-84af16c {align-self:center !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-84af16c-container stk--no-background stk--no-padding\"><div class=\"has-text-align-left-mobile stk-block-content stk-inner-blocks stk-84af16c-inner-blocks\">\n<div class=\"wp-block-stackable-button-group stk-block-button-group stk-block stk-ffe44e6\" data-block-id=\"ffe44e6\"><div class=\"stk-row stk-inner-blocks stk-block-content stk-button-group\">\n<div class=\"wp-block-stackable-icon-button stk-block-icon-button stk-block stk-4553922\" data-block-id=\"4553922\"><style>.stk-4553922 .stk-button{background:var(--theme-palette-color-1, #164193) !important;}.stk-4553922 .stk-button:hover{background:var(--theme-palette-color-2, #312a74) !important;opacity:1 !important;}<\/style><a class=\"stk-link stk-button stk--hover-effect-darken\" href=\"https:\/\/www.tandfonline.com\/doi\/abs\/10.1080\/15548627.2021.1991191\" target=\"_blank\" rel=\"noreferrer noopener\"><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 640 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M579.8 267.7c56.5-56.5 56.5-148 0-204.5c-50-50-128.8-56.5-186.3-15.4l-1.6 1.1c-14.4 10.3-17.7 30.3-7.4 44.6s30.3 17.7 44.6 7.4l1.6-1.1c32.1-22.9 76-19.3 103.8 8.6c31.5 31.5 31.5 82.5 0 114L422.3 334.8c-31.5 31.5-82.5 31.5-114 0c-27.9-27.9-31.5-71.8-8.6-103.8l1.1-1.6c10.3-14.4 6.9-34.4-7.4-44.6s-34.4-6.9-44.6 7.4l-1.1 1.6C206.5 251.2 213 330 263 380c56.5 56.5 148 56.5 204.5 0L579.8 267.7zM60.2 244.3c-56.5 56.5-56.5 148 0 204.5c50 50 128.8 56.5 186.3 15.4l1.6-1.1c14.4-10.3 17.7-30.3 7.4-44.6s-30.3-17.7-44.6-7.4l-1.6 1.1c-32.1 22.9-76 19.3-103.8-8.6C74 372 74 321 105.5 289.5L217.7 177.2c31.5-31.5 82.5-31.5 114 0c27.9 27.9 31.5 71.8 8.6 103.9l-1.1 1.6c-10.3 14.4-6.9 34.4 7.4 44.6s34.4 6.9 44.6-7.4l1.1-1.6C433.5 260.8 427 182 377 132c-56.5-56.5-148-56.5-204.5 0L60.2 244.3z\"\/><\/svg><\/div><\/span><\/a><\/div>\n<\/div><\/div>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-divider alignfull stk-block-divider stk--hide-desktop has-text-align-center stk-block stk-a7c2c6b\" data-block-id=\"a7c2c6b\"><style>.stk-a7c2c6b hr.stk-block-divider__hr{background:#abb8c3 !important;}@media screen and (max-width:689px){.stk-a7c2c6b {align-items:center !important;margin-bottom:0px !important;display:flex !important;}}<\/style><hr class=\"stk-block-divider__hr\"\/><\/div>\n\n\n\n<div class=\"wp-block-stackable-spacer stk-block-spacer stk--no-padding stk-block stk-143b0b8\" data-block-id=\"143b0b8\"><style>.stk-143b0b8 {height:30px !important;}@media screen and (max-width:689px){.stk-143b0b8 {height:30px !important;}}<\/style><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-greenshift-blocks-row-column gspb_row__col--3 gspb_col-id-gsbp-f78c24f\" id=\"gspb_col-id-gsbp-f78c24f\">\n<div class=\"wp-block-stackable-image stk-block-image stk-block stk-f475dab\" data-block-id=\"f475dab\"><style>.stk-f475dab .stk-img-wrapper{width:80% !important;}<\/style><figure><span class=\"stk-img-wrapper stk-image--shape-stretch\"><img loading=\"lazy\" decoding=\"async\" class=\"stk-img wp-image-1161\" src=\"https:\/\/www.leloir.org.ar\/research\/wp-content\/uploads\/2026\/06\/Fil__Wappner.png\" width=\"400\" height=\"400\" srcset=\"https:\/\/www.leloir.org.ar\/research\/wp-content\/uploads\/2026\/06\/Fil__Wappner.png 400w, https:\/\/www.leloir.org.ar\/research\/wp-content\/uploads\/2026\/06\/Fil__Wappner-300x300.png 300w, https:\/\/www.leloir.org.ar\/research\/wp-content\/uploads\/2026\/06\/Fil__Wappner-150x150.png 150w\" sizes=\"auto, (max-width: 400px) 100vw, 400px\" \/><\/span><\/figure><\/div>\n\n\n\n<div class=\"wp-block-stackable-text stk-block-text stk-block stk-b236174\" data-block-id=\"b236174\"><style>.stk-b236174 {margin-bottom:0px !important;}<\/style><p class=\"stk-block-text__text\"><span style=\"color: #ffffff;\" class=\"stk-highlight\">Principal investigator<\/span><\/p><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-c6eea5f\" id=\"pablo-wappner-ph-d\" data-block-id=\"c6eea5f\"><style>.stk-c6eea5f .stk-block-heading__text{line-height:1.2em !important;}<\/style><h4 class=\"stk-block-heading__text\">Pablo Wappner, PhD<\/h4><\/div>\n\n\n\n<div class=\"wp-block-stackable-icon-label stk-block-icon-label stk-block stk-920abd0\" data-block-id=\"920abd0\"><style>.stk-920abd0 .stk-inner-blocks{gap:10px !important;}<\/style><div class=\"stk-row stk-inner-blocks stk-block-content\">\n<div class=\"wp-block-stackable-icon stk-block-icon has-text-align-left stk-block stk-dd29c01\" data-block-id=\"dd29c01\"><style>.stk-dd29c01 .stk--svg-wrapper .stk--inner-svg svg:last-child{height:22px !important;width:22px !important;}.stk-dd29c01 .stk--svg-wrapper .stk--inner-svg svg:last-child, .stk-dd29c01 .stk--svg-wrapper .stk--inner-svg svg:last-child :is(g, path, rect, polygon, ellipse){fill:var(--theme-palette-color-5, #35b6b4) !important;}<\/style><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg style=\"height:0;width:0\"><defs><linearGradient id=\"linear-gradient-dd29c01\" x1=\"0\" x2=\"100%\" y1=\"0\" y2=\"0\"><stop offset=\"0%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-dd-29-c-01-color-1)\"><\/stop><stop offset=\"100%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-dd-29-c-01-color-2)\"><\/stop><\/linearGradient><\/defs><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M64 112c-8.8 0-16 7.2-16 16v22.1L220.5 291.7c20.7 17 50.4 17 71.1 0L464 150.1V128c0-8.8-7.2-16-16-16H64zM48 212.2V384c0 8.8 7.2 16 16 16H448c8.8 0 16-7.2 16-16V212.2L322 328.8c-38.4 31.5-93.7 31.5-132 0L48 212.2zM0 128C0 92.7 28.7 64 64 64H448c35.3 0 64 28.7 64 64V384c0 35.3-28.7 64-64 64H64c-35.3 0-64-28.7-64-64V128z\"\/><\/svg><\/div><\/span><\/div>\n\n\n\n<div class=\"wp-block-stackable-heading stk-block-heading stk-block-heading--v2 stk-block stk-7b80074\" id=\"a-href-mailto-pwappner-leloir-org-ar-strong-pwappner-leloir-org-ar-strong-a\" data-block-id=\"7b80074\"><style>.stk-7b80074 .stk-block-heading__text{font-size:1.2rem !important;color:var(--theme-palette-color-5, #35b6b4) !important;}@media screen and (max-width:999px){.stk-7b80074 .stk-block-heading__text{font-size:1.2rem !important;}}<\/style><p class=\"stk-block-heading__text has-text-color\"><a href=\"mailto:pwappner@leloir.org.ar\"><strong>pwappner@leloir.org.ar<\/strong><\/a><\/p><\/div>\n<\/div><\/div>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<div class=\"wp-block-stackable-columns stk-block-columns stk-block stk-a0e1fa3\" data-block-id=\"a0e1fa3\"><div class=\"stk-row stk-inner-blocks stk-block-content stk-content-align stk-a0e1fa3-column\">\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-8ec3b2b\" data-v=\"4\" data-block-id=\"8ec3b2b\"><style>@media screen and (min-width:690px){.stk-8ec3b2b {flex:var(--stk-flex-grow, 1) 1 calc(20% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-8ec3b2b-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-8ec3b2b-inner-blocks\">\n<div class=\"wp-block-stackable-icon stk-block-icon stk-block stk-cacdf15\" data-block-id=\"cacdf15\"><style>.stk-cacdf15 .stk--svg-wrapper .stk--inner-svg svg:last-child{height:18px !important;width:18px !important;}.stk-cacdf15 .stk--svg-wrapper .stk--inner-svg svg:last-child, .stk-cacdf15 .stk--svg-wrapper .stk--inner-svg svg:last-child :is(g, path, rect, polygon, ellipse){fill:var(--theme-palette-color-3, #a7a04d) !important;}<\/style><span class=\"stk--svg-wrapper\"><div class=\"stk--inner-svg\"><svg style=\"height:0;width:0\"><defs><linearGradient id=\"linear-gradient-cacdf15\" x1=\"0\" x2=\"100%\" y1=\"0\" y2=\"0\"><stop offset=\"0%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-cacdf-15-color-1)\"><\/stop><stop offset=\"100%\" style=\"stop-opacity:1;stop-color:var(--linear-gradient-cacdf-15-color-2)\"><\/stop><\/linearGradient><\/defs><\/svg><svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 512 512\" aria-hidden=\"true\" width=\"32\" height=\"32\"><path d=\"M336 352c97.2 0 176-78.8 176-176S433.2 0 336 0S160 78.8 160 176c0 18.7 2.9 36.8 8.3 53.7L7 391c-4.5 4.5-7 10.6-7 17v80c0 13.3 10.7 24 24 24h80c13.3 0 24-10.7 24-24V448h40c13.3 0 24-10.7 24-24V384h40c6.4 0 12.5-2.5 17-7l33.3-33.3c16.9 5.4 35 8.3 53.7 8.3zM376 96a40 40 0 1 1 0 80 40 40 0 1 1 0-80z\"\/><\/svg><\/div><\/span><\/div>\n<\/div><\/div><\/div>\n\n\n\n<div class=\"wp-block-stackable-column stk-block-column stk-column stk-block stk-0ccde29\" data-v=\"4\" data-block-id=\"0ccde29\"><style>@media screen and (min-width:690px){.stk-0ccde29 {flex:var(--stk-flex-grow, 1) 1 calc(80% - var(--stk-column-gap, 0px) * 1 \/ 2 ) !important;}}<\/style><div class=\"stk-column-wrapper stk-block-column__content stk-container stk-0ccde29-container stk--no-background stk--no-padding\"><div class=\"stk-block-content stk-inner-blocks stk-0ccde29-inner-blocks\">\n<ul style=\"padding-right:0;padding-left:0\" class=\"wp-block-list\">\n<li class=\"has-palette-color-3-color has-text-color has-link-color wp-elements-6202363918818d7a24a53cd415eb6770\" style=\"line-height:1.3\">autophagy <br><\/li>\n\n\n\n<li class=\"has-palette-color-3-color has-text-color has-link-color wp-elements-b6d1695e3edcb616bc2ace1ea674dd44\" style=\"line-height:1.3\">hypoxia response<br><\/li>\n\n\n\n<li class=\"has-palette-color-3-color has-text-color has-link-color wp-elements-8d6af1da7494605769d27e583353c2b7\" style=\"line-height:1.3\"> vesicle trafficking<br><\/li>\n\n\n\n<li class=\"has-palette-color-3-color has-text-color has-link-color wp-elements-ee89424744a930caea2b0c72b98b8c0e\" style=\"line-height:1.3\">Drosophila development<br><\/li>\n\n\n\n<li class=\"has-palette-color-3-color has-text-color has-link-color wp-elements-8947e848eaf725d50a8056a78c21c28e\" style=\"line-height:1.3\">cell differentiation<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n<\/div><\/div>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-stackable-divider alignfull 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