Biochemistry and Molecular Biology of Development

Luis A. Quesada Allué - Fundación Instituto Leloir

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Biochemistry and Molecular Biology of Development

We study molecular and physiological aspects of insects development, focusing in the holometaboulous life cycle, using Ceratitis capitata, the Mediterranean fruitly (the Medfly) and other dipterans like Drosophila melanogaster as main models. The Medfly is the main orchard pest world-wide, with significant economic importance in Argentina. Our current interest is on the study of parameters related to Functional Senescence of adults, with independence of age, using both behavioral and molecular approaches, particularly lipid profiles. We also study a novel mechanism for neurotransmitters regulation through the formation of Beta-alanine-conjugates in insect brain. The same mechanism is triggered by the innate immune response. We develop similar studies in the Hornfly, a main cattle pest and other insects.
  • Parameters of Functional Senescence in pest-flies.
  • Novel metabolism of beta-alanyl-conjugates of catecholamines in insects.
  • Photosensitive substances acting as photo-insecticides in dipterans.

Gabriela A. Pizzurro , Florencia P. Madorsky Rowdo , Luciana M. Pujol-Lereis, Luis A. Quesada-Allue , Andrea M. Copati , Maria P. Roberti , Jean-Luc Teillaud, Estrella M. Levy , Maria M. Barrio , Jose Mordoh 2012 Cancer Immunology & Immunotherapy DOI 10.1007/s00262-012-1295-4 PubMed

Pujol-Lereis, L.M., Rabossi, A. y Quesada-Allué, L.A. Lipid profiles as indicators of functional senescence in the medfly Experimental Gerontology DOI: 10:16/J.EXGER.2012.04.001 (2012) PubMed

Pérez, M.M., Sabio, G. Badaracco, A. and Quesada-Allué, L.A. Constitutive expression and enzymatic activity of Tan protein in brain and epidermis of Ceratitis capitata and of Drosophila melanogaster wild-type and tan mutants. Insect Biochemistry and Molecular Biology 41 (9):653-659 (2011) PubMed

Sabio, G., L.A. Quesada-Allue, and M.M. Perez. NBAD-hydrolase processing in brain and epidermis of Drosophila melanogaster. Drosophila information Service 94:100-104 (2011)

Basso, A., Forneris, N., Filiberti, A.., Argaraña, C., Rabossi, A., and Quesada-Allué,L.A. Metamorphosis and gonad maturation in the horn fly,Haematobia irritans Journal of Insect Science 11: 1-10 (2011) PubMed

Pujol-Lereis, L.M., Massaldi, A., Rabossi, A., Quesada-Allué, L.A. Photosensitizing effect of hematoporphyrin IX on immature stages of Ceratitis capitata (Diptera: Tephritidae). Photochem Photobiol. 86: 639-644 (2010).     PubMed

Pérez, M.M., Schachter, J., Berni, J., Quesada-Allué, L.A. The enzyme NBAD-synthase plays diverse roles during the life cycle of Drosophila melanogaster. J Insect Physiol. 56: 8-13 (2010).     PubMed

Sabio, G, Quesada-Allué, L.A. and Pérez, M.M. Embryo and larval survival in Drosophila melanogaster pigmentation mutants tan and ebony Drosophila Information Service 93:175-178

Berni, J., Rabossi, A., Pujol-Lereis, L.M., Tolmasky, D.S., Quesada-Allué, L.A. Phloxin B affects glycogen metabolism in larval stages of Ceratitis capitata (Diptera, Tephritidae). Pestic Biochem Physiol. 95: 12-17 (2009).     doi:10.1016/j.pestbp.2009.04.012

Badaracco, A., L.A. Quesada-Allué, and M.M. Pérez. “Drosophila melanogaster mutant tan”. Drosophila. Inf. Serv. 92, 90-93 (2009)

Rabossi, A., Stoka, V., Puizdar, V., Turk, V., Quesada-Allué, L.A. Purification and characterization of two cysteine peptidases of the Mediterranean fruit fly Ceratitis capitata during metamorphosis. Arch Insect Biochem Physiol.68: 1-13 (2008).     PubMed

Filiberti, A., Rabossi, A., Argaraña, C.E., Quesada-Allué, L.A. Evaluation of Phloxine B as a photoinsecticide on immature stages of the horn fly Haematobia irritans. Aust J Entomol. 48: 73-78 (2008).     doi:10.1111/j.1440-6055.2008.00686.x

Quesada-Allué, L.A., Argaraña, C., Basso, A., Filiberti, A., Forneris, N., Pérez, M. Pujol-Leris, L., Rabossi, A.Avances en el estudio de poblaciones argentinas de la mosca de los cuernos, haematobia irritans: biología y sensibilidad a larvicidas fotoactivables. PROY. BID-1201/OC- AR- PICT 2003-351 78pp 1-48 (2008).   Informe Técnico





Luis A. Quesada Allué
Head of Laboratory - lualque@iib.uba.ar



Alicia Basso
Visitante Nacional



Pablo Bochicchio
Estudiante de Licenciatura



Martín Pérez
Investigador Asociado



Luciana Pujol Lereis
Becario Doctoral CONICET



Alejandro Rabossi
Investigador Asociado



Fabiana Rossi
Becaria de iniciación UBA (Pre-grado)