Physicochemistry of infectious diseases

Daiana Capdevila - Fundación Instituto Leloir

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Jordan, M. R.; Wang, J.; Weiss, A.; Skaar, E. P.; Capdevila, D. A.; Giedroc, D. P. Mechanistic Insights into the Metal-Dependent Activation of ZnII -Dependent Metallochaperones. Inorg. Chem. 2019, acs.inorgchem.9b01173.

Martin, J. E.; Le, M. T.; Bhattarai, N.; Capdevila, D. A.; Shen, J.; Winkler, M. E.; Giedroc, D. P. A Mn-Sensing Riboswitch Activates Expression of a Mn2+/Ca2+ ATPase Transporter in Streptococcus. Nucleic Acids Res. 2019, 1–15.

Wang, J.; Capdevila, D. A.; Giedroc, D. P. Metal Ion Homeostasis. In Comprehensive Coordination Chemistry III; 2019; Chapter 80005.

Capdevila, D. A.; Edmonds, K. A.; Campanello, G. C.; Wu, H.; Gonzalez-Gutierrez, G.; Giedroc, D. P. Functional Role of Solvent Entropy and Conformational Entropy of Metal Binding in a Dynamically Driven Allosteric System. J. Am. Chem. Soc. 2018, 140 (29), 9108–9119.

Capdevila, D. A.; Huerta, F.; Edmonds, K. A.; Le, M. T.; Wu, H.; Giedroc, D. P. Tuning Site-Specific Dynamics to Drive Allosteric Activation in a Pneumococcal Zinc Uptake Regulator. Elife 2018, 7

Glauninger, H.; Zhang, Y.; Higgins, K. A.; Jacobs, A. D.; Martin, J. E.; Fu, Y.; Coyne Rd, H. J.; Bruce, K. E.; Maroney, M. J.; Clemmer, D. E.; et al. Metal-Dependent Allosteric Activation and Inhibition on the Same Molecular Scaffold: The Copper Sensor CopY from Streptococcus Pneumoniae. Chem. Sci. 2018, 9 (1), 105–118.

Capdevila, D. A.; Edmonds, K. A.; Giedroc, D. P. Metallochaperones and Metalloregulation in Bacteria. Essays Biochem. 2017, 61 (2), 177–200.

Capdevila, D. A.; Braymer, J. J.; Edmonds, K. A.; Wu, H.; Giedroc, D. P. Entropy Redistribution Controls Allostery in a Metalloregulatory Protein. Proc. Natl. Acad. Sci. U. S. A. 2017, 114 (17), 4424–4429.

Capdevila, D. A.; Wang, J.; Giedroc, D. P. Bacterial Strategies to Maintain Zinc Metallostasis at the Host-Pathogen Interface. J. Biol. Chem. 2016, 291 (40), 20858–20868.

Hannibal, L.; Tomasina, F.; Capdevila, D. A.; Demicheli, V.; Tórtora, V.; Alvarez-Paggi, D.; Jemmerson, R.; Murgida, D. H.; Radi, R. Alternative Conformations of Cytochrome c: Structure, Function, and Detection. Biochemistry 2016, 55 (3), 407–428

Capdevila, D. A.; Oviedo Rouco, S.; Tomasina, F.; Tortora, V.; Demicheli, V.; Radi, R.; Murgida, D. H. Active Site Structure and Peroxidase Activity of Oxidatively Modified Cytochrome c Species in Complexes with Cardiolipin. Biochemistry 2015, 54 (51), 7491–7504.

Capdevila, D. A.; Marmisollé, W. A.; Tomasina, F.; Demicheli, V.; Portela, M.; Radi, R.; Murgida, D. H. Specific Methionine Oxidation of Cytochrome c in Complexes with Zwitterionic Lipids by Hydrogen Peroxide: Potential Implications for Apoptosis. Chem. Sci. 2015, 6 (1), 705–713.

Capdevila, D. A.; Álvarez-Paggi, D.; Castro, M. A.; Tórtora, V.; Demicheli, V.; Estrín, D. A.; Radi, R.; Murgida, D. H. Coupling of Tyrosine Deprotonation and Axial Ligand Exchange in Nitrocytochrome C. Chem. Commun. 2014, 50 (20), 2592.





Daiana Capdevila
Head of Laboratory - dcapdevila@leloir.org.ar



Matías Villarruel Dujovne
Chemistry student



Ivan Schlamovitz
Chemistry student



Sofía Liuboschitz
Student of biology



Majo Silberg
Student of biology



María Florencia Crevatin
Student of biology