Comparative Genomics of Plant Development

Marcelo J. Yanovsky - Fundación Instituto Leloir

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Our laboratory studies the genetic basis that mediate the adjustment of growth and development of plants to their environment. Mainly, studying post-transcriptional mechanisms that regulates the circadian rhythms of the model plant Arabidopsis thaliana. For this high throughput analysis and molecular and physiological approaches are combined.

ClockSanchez, et. al. Elife (2013).

Fig2Perez-Santángelo, et al. Brief Funct Genomics (2013).

Under Construction

Mancini, E., Sanchez, S. E., Romanowski, A., Schlaen, R. G., Sanchez‐Lamas, M., Cerdán, P. D., & Yanovsky, M. J.Acute Effects of Light on Alternative Splicing in Light‐Grown Plants. Photochemistry and photobiology (2016) 92(1), 126-133. PubMed

Schlaen RG, Mancini E, Sanchez SE, Perez-Santángelo S, Rugnone ML, Simpson CG, Brown JW, Zhang X, Chernomoretz A, Yanovsky MJ. The spliceosome assembly factor GEMIN2 attenuates the effects of temperature on alternative splicing and circadian rhythms. Proc Natl Acad Sci USA (2015) V 112 p.9382-9387. PubMed

Romanowski A, Yanovsky MJ. Circadian rhythms and post-transcriptional regulation in higher plants. Frontiers in Plant Science (2015). Vol 6 p.437. PubMed

Hernando, Carlos E;  Sanchez, Sabrina E;  Mancini, Estefanía;  Yanovsky, Marcelo J. Genome wide comparative analysis of the effects of PRMT5 and PRMT4/CARM1 arginine methyltransferases on the Arabidopsis thaliana transcriptome. BMC genomics (2015). Vol 16 p. 192. PubMed

Perez-Santángelo S, Mancini E, Francey LJ, Schlaen RG, Chernomoretz A, Hogenesch JB, Yanovsky MJ (2014). Role for LSM genes in the regulation of circadian rhythms. Proc Natl Acad Sci U S A;111(42):15166-71. PubMed

Beckwith EJ, Yanovsky MJ. Circadian regulation of gene expression: at the crossroads of transcriptional and post-transcriptional regulatory networks. Curr Opin Genet Dev. (2014). 27:35-42. PubMed

Perez-Santángelo S, Schlaen RG, Yanovsky MJ. Genomic analysis reveals novel connections between alternative splicing and circadian regulatory networks. Brief Funct Genomics. (2013). Review. PubMed

Sanchez SE, Yanovsky MJ. Time for a change. Elife (2013). 2:e00791. Review. PubMed

Rugnone ML, Faigón Soverna A, Sanchez SE, Schlaen RG, Hernando CE, Seymour DK, Mancini E, Chernomoretz A, Weigel D, Más P, Yanovsky MJ (2013). LNK genes integrate light and clock signaling networks at the core of the Arabidopsis oscillator. Proc Natl Acad Sci USA (2013). 110(29):12120-5. PubMed

Sanchez SE, Petrillo E, Kornblihtt AR, Yanovsky MJ. Alternative splicing at the right time. RNA Biol. (2011). 8(6):954-9. Review. PubMed

Sánchez SE, Petrillo E, Beckwith EJ, Zhang Xu, Rugnone ML, Hernando CE, Cuevas J, Godoy Herz MA, Depetris-Chauvin A, Simpson CG, Brown JWS, Cerdán PD, Borevitz JO, Mas P, Ceriani MF, Kornblihtt AR & Yanovsky MJ. A methyl transferase links the circadian clock to the regulation of alternative splicing. Nature (2010). 468, 112-116. PubMed

Más P, Yanovsky MJ. Time for circadian rhythms: plants get synchronized. Curr Opin Plant Biol. (2009). (5):574-9. Review. PubMed

Faigón-Soverna A, Harmon FG, Storani L, Karayekov E, Staneloni RJ, Gassmann W, Más P, Casal JJ, Kay SA, Yanovsky MJ. A constitutive shade-avoidance mutant implicates TIR-NBS-LRR proteins in Arabidopsis photomorphogenic development. Plant Cell (2006). (11):2919-2928. PubMed.    

Yanovsky, M.J., Kay, S.A. Molecular basis of seasonal time measurement in Arabidopsis. Nature. 419:308-312 (2002).    PubMed





Marcelo Yanovsky, PhD
Group leader-Investigator (Independiente) CONICET - myanovsky@leloir.org.ar



Julieta Mateos, PhD
Investigator (Asistente) CONICET - jmateos@leloir.org.ar



Santiago Mora Garcia, PhD
Investigator (Adjunto) CONICET - smora@leloir.org.ar



Carolina Garcia, PhD
Post-Doctoral Fellow CONICET - cgarcia@leloir.org.ar



Andres Romanowski, PhD
Post-doctoral Fellow-Bunge&Born Foundation - aromanowski@leloir.org.ar



Carlos Esteban Hernando, PhD
Post-doctoral Fellow-Bunge&Born Foundation - chernando@leloir.org.ar



Soledad Perez-Santangelo, PhD
Post-Doctoral Fellow CONICET - sperez@leloir.org.ar



Estefanía Mancini
PhD Student-CONICET - emancini@leloir.org.ar



María José De Leone
PhD Student-CONICET - mjdeleone@leloir.org.ar



Joaquin Casal
Undergraduate Student - jfcasal@leloir.org.ar



Esteban Beckwith, PhD
Former Post-doctoral fellow- Fundación Bunge y Born - ebeckwith@leloir.org.ar



Ana Faigón-Soverna, PhD
Former Post-doctoral fellow



Sabrina Sánchez, PhD
Former Post-doctoral fellow



Gustavo Schlaen, PhD
Former Post-doctoral fellow- Fundación Bunge y Born



Matías Rugnone, PhD
Former PhD Student



Martina Legris
Former Undergraduate Student



Francisco Astigueta
Former Student