Terapias regenerativas y protectoras del Sistema Nervioso
Jefe de Laboratorio: Dr. Fernando Pitossi
Publicaciones
Garciarena, M., Depino, A., Pitossi, F.J. Prenatal inflammation impairs adult neurogenesis and memory related behavior through persistent hippocampal TGFb1 downregulation. Brain Behav Imm. (en prensa).
De Lella Ezcurra, A.L., Chertoff, M., Graciarena, M., Ferrari, C., Pitossi, F.J. Chronic expresión of low levels of Tumor necrosis factor alpha in the substantia nigra elicits progressive neurodegeneration delayed motor symptoms and microglia/macrophage activation. Neurobiol Dis. 37: 630-640 (2010). PubMed
Mathieu, P., Battista, D., Depino, A., Roca, V., Pitossi, F.J. The more you have, the less you get: the functional role of inflammation on neuronal differentiation of endogenous and transplanted neural stem cells in the adult brain. J Neurochem. 112: 1368-1385 (2010). PubMed
Pott Godoy, M.C., Ferrari, C.C., Pitossi, F.J. Nigral neurodegeneration triggered by striatal AdlL-1 administration can be exacerbated by systemic expression. J Neuroimmunol. 222: 29-39 (2010). PubMed
Pott Godoy, M.C., Tarelli, R., Ferrari, C.C., Sarchi, M.I.S., Pitossi, F.J. Central and systemic IL-1 exacerbates neurodegeneration and motor symptoms in a model of Parkinson’s disease. Brain. 131: 1880-1894 (2008). PubMed
Battista, D., Ferrari, C.C., Gage, F.H., Pitossi, F.J. Neurogenic niche modulation by activated microglia: transforming growth factor beta increases neurogenesis in the adult dentate gyrus. Eur. J. Neurosci. 23: 83-93 (2006). PubMed
Ferrari, C.C., Depino, A.M., Prada, F., Muraro, N., Campbell, S., Podhajcer, O.L., Perry, V.H., Anthony, D.C., Pitossi, F.J. Reversible demyelination, blood-brain barrier breakdown, and pronounced neutrophil recruitment induced by chronic IL-1 expression in the brain. Am. J. Pathol. 165: 1827-1837 (2004). PubMed
Pitossi, F.J., Blank, A., Schröder, A., Schwarz, A., Hüssi, P. Schwemmle, M., Pavlovic, J., Staeheli, P. A functional GTP-binding motif is necessary for antiviral activity of Mx proteins. J Virol. 67: 6726-6732 (1993). PubMed