Inmunología y Microbiología Molecular
Jefe de Laboratorio: Dr. Fernando Goldbaum
Publicaciones
Ainciart, N., Zylberman, V., Craig, P., Nygaard, D., Bonomi, H., Cauerhff, A., Goldbaum, F.A. Sensing the dissociation of a polymeric enzyme by means of an engineered intrinsic probe. Proteins. (En prensa). PubMed
Alzogaray, V., Danquah, W., Aguirre, A., Urrutia, M., Berguer, P., García Véscovi, E., Haag, F., Koch-Nolte, F., Goldbaum, F.A. Single-domain llama antibodies as specific intracellular inhibitors of SpvB, the actin ADP-ribosylating toxin of Salmonella typhimurium. FASEB J. (En prensa). PubMed
Doña, V., Urrutia, M., Bayardo, M., Alzogaray, V., Goldbaum, F.A., Chirdo, F.G. Single domain antibodies are specially suited for quantitative determination of gliadins under denaturing conditions. J Agric Food Chem. 58: 918-926 (2010). PubMed
Rinaldi, J., Wu, J., Yang, J., Ralston, C.Y., Sankaran, B., Moreno, S., Taylor, S.S. Structure of yeast regulatory subunit: a glimpse into the evolution of PKA signaling. Structure. 18:1471-1482 (2010). PubMed
Mundiñano, J., Berguer, P.M., Cabrera, G., Lorenzo, D., Nepomnaschy, I., Piazzon, I. Superantigens increase the survival of mice bearing T cell lymphomas by inducing apoptosis of neoplastic cells. PLoS One. 5: e15694 (2010). PubMed
Eliçabe R.J., Cargnelutti E., Serer M.I., Stege P.W., Valdez S.R., Toscano M.A., Rabinovich G.A., Di Genaro M.S. Lack of TNFR p55 results in heightened expression of IFN-γ and IL-17 during the development of reactive arthritis. J Immunol.185: 4485-44895 (2010). PubMed
Malamud, F., Torres, P.S., Roxana, R., Rigano, L.A., Enrique, R., Bonomi, H., Castagnaro, A.P., Marano, M.R., Vojnov, A. Xanthomonas axonopodis pv. citri flagellum is required for mature biofilm and canker development. Microbiology. (En prensa). PubMed
Bonomi, H.R., Marchesini, M.I., Klinke, S., Ugalde, J.E., Zylberman, V., Ugalde, R.A., Comerci, D.J., Goldbaum, F.A. An atypical riboflavin pathway is essential for Brucella abortus virulence. PLos One. 5: e9435 (2010). PubMed
Doña, V., Urrutia, M., Bayardo, M., Alzogaray, V., Goldbaum, F.A., Chirdo, F.G. Single domain antibodies are specially suited for quantitative determination of gliadins under denaturing conditions. J Agric Food Chem. 58: 918-926 (2010). PubMed
Bellido, D., Craig, P.O., Mozgovoj, M.V., Gonzalez, D.D., Wigdorovitz, A., Goldbaum, F.A., Dus Santos, M.J. Brucella spp. lumazine synthase as a bovine rotavirus antigen delivery system. Vaccine. 27: 136-145 (2009). PubMed
Estein, S.M., Fiorentino, M.A., Paolicchi, F.A., Clausse, M., Manazza, J., Cassataro, J., Giambartolomei, G.H., Coria, L.M., Zylberman, V., Fossati, C.A., Kjeken, R., Goldbaum, F.A. The polymeric antigen BLSOmp31 confers protection against Brucella ovis infection in rams. Vaccine. 27: 6704-6711 (2009). PubMed
Wesolowski, J., Alzogaray, V., Reyelt, J., Unger, M., Juarez, K., Urrutia, M., Cauerhff, A., Danquah, W., Rissiek, B., Scheuplein, F., Schwarz, N., Adriouch, S., Boyer, O., Seman, M., Licea, A., Serreze, D.V., Goldbaum, F.A., Haag, F., Koch-Nolte, F.. Single domain antibodies: promising experimental and therapeutic tools in infection and immunity. Med Microbiol Immunol. 198: 157-174 (2009). PubMed
Carrica, M. del C., Craig, P.O., Valle Alonso, S. del, Goldbaum, F.A., Cravero, S.L. Brucella abortus MFP: A trimeric coiled-coil protein with membrane fusogenic activity. Biochemistry. 47: 8165-8175 (2008). PubMed
Primo, M.E., Klinke, S., Sica, M.P., Goldbaum, F.A., Jakoncic, J., Poskus, E., Ermacora, M.R. Structure of the mature ectodomain of the human receptor-type protein-tyrosine phosphatase IA-2. J Biol Chem. 283: 4674-4681 (2008). PubMed
Ratier L., Urrutia M., Paris G., Zarebski L., Frasch A.C., Goldbaum F.A. Relevance of the diversity among members of the Trypanosoma cruzi trans-sialidase family analyzed with camelids single-domain antibodies. PLoS ONE. 3: e3524 (2008). PubMe
Acierno, J.P., Braden, B.C., Klinke, S., Goldbaum, F.A., Cauerhff, A. Affinity maturation increases the stability and plasticity of the Fv domain of anti-protein antibodies. J Mol Biol. 374: 130-146 (2007). PubMed
Cassataro, J., Pasquevich, K.A., Estein, S.M., Laplagne, D.A., Velikovsky, C.A., de la Barrera, S., Bowden, R., Fossati, C.A., Giambartolomei, G.H., Goldbaum, F.A. A recombinant subunit vaccine based on the insertion of 27 amino acids from Omp31 to the N-terminus of BLS induced a similar degree of protection against B. ovis than Rev.1 vaccination. Vaccine. 25: 4437-46 (2007). PubMed
Cassataro J., Pasquevich, K.A., Estein, S.M., Laplagne, D.A., Zwerdling, A., de la Barrera, S., Bowden, R., Fossati, C.A., Giambartolomei, G.H., Goldbaum, F.A. A DNA vaccine coding for the chimera BLSOmp31 induced a better degree of protection against B. ovis and a similar degree of protection against B. melitensis than Rev.1 vaccination. Vaccine. 25: 5958-5967 (2007). PubMed
Klinke, S., Zylberman, V., Bonomi, H.R., Haase, I., Guimarães, B.G., Braden, B.C., Bacher, A., Fischer, M., Goldbaum, F.A. Structural and kinetic properties of lumazine synthase isoenzymes in the order Rhizobiales. J Mol Biol. 373: 664-680 (2007). PubMed
Koch-Nolte, F., Reyelt, J., Schössow, B., Schwarz, N., Scheuplein, F., Rothenburg, S., Haag F., Alzogaray, V., Cauerhff, A., Goldbaum, F.A. Single domain antibodies from llama effectively and specifically block T cell ecto-ADP-ribosyltransferase ART2.2 in vivo. FASEB J. 21: 3490-3498 (2007). PubMed
Sanguineti, S., Centeno Crowley, J.M., Lodeiro Merlo, M.F., Cerutti, M.L., Wilson, I.A., Goldbaum, F.A., Stanfield, R.L., Prat-Gay, G. de. Specific recognition of a DNA immunogen by its elicited antibody. J Mol Biol. 370: 183-195 (2007). PubMed
Sciutto, E., Rosas, G., Cruz-Revilla, C., Toledo, A., Cervantes,J., Hernández, M., Hernándezt, B., Goldbaum, F.A., de Aluja, A.S., Fragoso, G., Larralde, C. Renewed hope for a vaccine against the intestinal adult Taenia solium. J Parasitol. 93: 824-831 (2007). PubMed
Sciutto, E., Rosas, G., Hernández, M., Morales, J., Cruz-Revilla, C., Toledo, A., Manoutcharian, K., Gevorkian, G., Blancas, A., Acero, G., Hernández, B., Cervantes, J., Bobes, R.J., Goldbaum, F.A., Huerta, M., Diaz-Orea, A., Fleury, A., de Aluja, A.S., Cabrera-Ponce, J.L., Herrera-Estrella, L., Fragoso, G., Larralde, C. Improvement of the synthetic tri-peptide vaccine (S3Pvac) against porcine Taenia solium cysticercosis in search of a more effective, inexpensive and manageable vaccine. Vaccine. 25: 1368-1378 (2007). Review PubMed
Swartz, T.E., Tseng, T.S., Frederickson, M.A., Paris, G., Comerci, D.J., Rajashekara, G., Kim, J.G., Mudgett, M.B., Splitter, G.A., Ugalde, R.A., Goldbaum, F.A., Briggs, W.R., Bogomolni, R.A. Blue-light-activated histidine kinases: two-component sensors in bacteria. Science. 317: 1090-1093 (2007). PubMed