Genética y Fisiología Molecular
Jefe de Laboratorio: Dr. Pablo Wappner
Publicaciones
Centanin, L., Gorr, T.A., Wappner, P. Tracheal remodelling in response to hypoxia. J Insect Physiol. 56: 447-454 (2010). PubMed
Dekanty, A., Romero, N.M., Bertolin, A.P., Thomas, M.G., Leishman, C.C., Perez-Perri, J.I., Boccaccio, G.L., Wappner, P. Drosophila genome-wide RNAi screen identifies multiple regulators of HIF dependent transcription in hypoxia. PLoS Cenet. 6: e1000994 (2010). PubMed
Irisarri, M., Lavista-Llanos, S., Romero, N.M., Centanin, L., Dekanty, A., Wappner, P. Central role of the oxygen-dependent degradation domain of Drosophila HIFalpha/Sima in oxygen-dependent nuclear export. Mol Biol Cell. 20: 3878-3887(2009). PubMed
Centanin, L., Dekanty, A., Romero, N., Irisarri, M., Gorr, T.A., Wappner, P. Cell autonomy of HIF effects in Drosophila: Tracheal cells sense hypoxia and induce terminal branch sprouting. Dev Cell. 14: 547-558 (2008). PubMed
Romero, N.M., Irisarri, M., Roth, P., Cauerhff, A., Samakovlis, C., Wappner, P. Regulation of the Drosophila hypoxia-inducible factor alpha sima by CRM1-dependent nuclear export. Mol Cell Biol. 28: 3410-3423 (2008). PubMed
Rojas, D.A., Munizaga, D.A., Centanin, L., Antonelli, M., Wappner, P., Allende, M.L., Reyes, A.E. Cloning of hif-1a and hif-2a and mRNA expression pattern during development in zebrafish. Gene Expr Patterns. 7: 339-345 (2007). PubMed
Romero, N.M., Dekanty, A., Wappner, P. Cellular and developmental adaptations to hypoxia: a Drosophila perspective. Methods Enzymol. 435: 123-144. (2007). Review PubMed
Gorr, T.A., Gassmann, M., Wappner, P. Sensing and responding to hypoxia via HIF in model invertebrates. J. Insect. Physiol. 52: 349-364 (2006). Review PubMed
Centanin, L., Ratcliffe, P.J., Wappner, P. Reversion of lethality and growth defects in Fatiga oxygen-sensor mutant flies by loss of Hypoxia-Inducible Factor-alpha/Sima. EMBO Rep. 6: 1070-1075 (2005). PubMed
Dekanty, A., Lavista-Llanos, S., Irisarri, M., Oldham, S., Wappner, P. The insulin-PI3K/TOR pathway induces a HIF-dependent transcriptional response in Drosophila by promoting nuclear localization of HIF-alpha/Sima. J. Cell. Sci. 118: 5431-5441 (2005). PubMed
Muzzopappa, M., Wappner, P. Multiple roles of the F-box protein Slimb in Drosophila egg chamber development. Development 132: 2561-2571(2005). PubMed