Cancerología
Jefe de Laboratorio: Dr. José Mordoh
Publicaciones
Aris, M., Barrio, M.M., Mordoh, J. Cutaneous melanoma a test field for immunotherapy and a medical challenge. Curr Cancer Rev Ther. (en prensa).
Levy, E.M., Sycz, G., Arriaga, J.M., Barrio, M.M., von Euw, E.M., Morales, S.B., González, M., Mordoh, J., Bianchini, M. Cetuximab-mediated cellular cytotoxicity is inhibited by HLA-E membrane expression in colon cancer cells. Innate Immun. 15: 91-100 (2009). PubMed
Powlesland, A.S., Hitchen, P.G., Parry, S., Graham, S.A., Barrio, M.M., Elola, M.T., Mordoh, J., Dell, A., Drickamer, K., Taylor, M.E. Targeted glycoproteomic identification of cancer cell glycosylation. Glycobiology. 19: 899-909 (2009). PubMed
Fuertes, M.B., Girart, M.V., Molinero, L.L., Domaica, C.I., Rossi, L.E., Barrio, M.M., Mordoh, J., Rabinovich, G.A., Zwirner, N.W. Intracellular retention of the NKG2D ligand MHC class I chain-related gene a in human melanomas confers immune privilege and prevents NK cell-mediated cytotoxicity. J Immunol. 180: 4606-4614 (2008). PubMed
Kauffman, M.A., Levy, E.M., Consalvo, D., Mordoh, J., Kochen, S. “GABABR1 (G1465A) gene variation and temporal lobe epilepsy controversy: New evidence”. Seizure. 17: 567-571 (2008). PubMed
Levy, E.M., Bianchini, M., Von Euw, E.M., Barrio, M.M., Bravo, A.I., Furman, D., Domenichini, E., Macagno, C., Pinsky, V., Zucchini, C., Valvassori, L., Mordoh, J. Human leukocyte antigen-E protein is overexpressed in primary human colorectal cancer. Int J Oncol. 32: 633-641 (2008). PubMed
Von Euw, E.M., Barrio, M.M., Furman, D., Levy, E.M., Bianchini, M., Peguillet, I., Lantz, O., Vellice, A., Kohan, A., Chacón, M., Yee, C., Wainstok, R., Mordoh, J. A phase 1 clinical study of vaccination of melanoma patients with dendritic cells loaded with allogeneic apoptotic / necrotic melanoma cells. Analysis of toxicity and immune response to the vaccine and of IL-10-1082 promoter genotype as predictor of disease progression. J Transl Med. 6: 6 (2008). PubMed
Elola, M.T., Capurro, M.I., Barrio, M.M., Coombs, P.J., Taylor, M.E., Drickamer, K., Mordoh, J. Lewis x antigen mediates adhesion of human breast carcinoma cells to activated endothelium. Possible involvement of the endothelial scavenger receptor C-type lectin. Breast Cancer Res Treat. 101: 161-174 (2007). PubMed
Gazzaniga, S., Bravo, A.I., Guglielmotti, A., van Rooijen, N., Maschi, F., Vecchi, A., Mantovani, A., Mordoh, J., Wainstok, R. Targeting tumor-associated macrophages and inhibition of MCP-1 reduce angiogenesis and tumor growth in a human melanoma xenograft. J Invest Dermatol. 127: 2031-2041 (2007). PubMed
Von Euw, E.M., Barrio, M.M., Furman, D., Bianchini, M., Levy, E.M., Yee, C., Li, Y., Wainstok, R., Mordoh, J. Monocyte-derived dendritic cells loaded with a mixture of apoptotic/necrotic melanoma cells efficiently cross-present gp100 and MART-1 antigens to specific CD8+ T lymphocytes. J Transl Med. 5: 19 (2007). PubMed