Biología Estructural y Celular
Jefe de Laboratorio: Dr. Julio J. Caramelo
Publicaciones
D'Alessio, C., Caramelo, J., Parodi, A.J. UDP-GlC:glycoprotein glucosyltransferase-glucosidase II, the ying-yang of the ER quality control. Semin Cell Dev Biol. 21: 491-499 (2010). PubMed
Villamil, A., Lopez Medus, M., González Lebrero, M., Pagano, R., Labriola, C., Landolfo, L., Delfino, J., Parodi, A., Caramelo, J. The structure of calreticulin C-terminal domain is modulated by physiological variations of calcium concentration. J Biol Chem. 285: 4544-4553 (2010). PubMed
Craig, P., Gómez, G., Ureta, D., Caramelo, J., Delfino, J. Experimentally approaching the solvent accessible surface area of a protein: Insights into non-native states of bovine a-lactalbumin. J Mol Biol. 394: 982-993 (2009). PubMed
Franchini, G., Curto, L., Caramelo, J., Delfino, J. Dissection of a b-barrel motif leading to a functional dimer: the case of fatty acid binding protein. Prot Sci. 18: 2592-2602 (2009). PubMed
Stigliano, I., Caramelo, J., Labriola, C.A., Parodi, A., D'Alessio, C. Glucosidase II Beta Subunit Modulates N-Glycan Trimming in Fission Yeasts and Mammals. Mol Biol Cell. 20: 3974-3984 (2009). PubMed
Curto, L., Franchini, G., Caramelo, J., Delfino, J. Delta98Delta, a minimalist model of antiparallel beta-sheet proteins based on intestinal fatty acid binding protein. Prot Sci. 18: 735-746 (2009). PubMed
Caramelo, J., Iusem, N. When cells lose water: lessons from biophysics and molecular biology. Prog Biophys Mol Biol. 99: 1-6 (2009). PubMed
Caramelo, J., Parodi, A. Getting in and out from calnexin/calreticulin cycles. J Biol Chem. 283: 10221-10225 (2008). PubMed
Caramelo, J., Parodi, A. How sugars convey information on protein conformation in the endoplasmic reticulum. Semin Cell Dev Biol. 18: 732-742 (2007). PubMed
Conte, I., Keith, N., Gutiérrez-González, C., Parodi, A., Caramelo, J. The interplay between calcium and the in vitro lectin and chaperone activities of calreticulin. Biochemistry. 46: 4671-4680 (2007). PubMed
Keith, N., Parodi, A., Caramelo, J. Glycoprotein tertiary and quaternary structures are monitored by the same quality control mechanism. J Biol Chem. 280: 18138-18141 (2005). PubMed
Curto, L., Caramelo, J., Delfino, J. Delta98delta, a functional all-beta-sheet abridged form of intestinal fatty acid binding protein. Biochemistry. 44: 13847-13857 (2005). PubMed
D´Alessio, C., Caramelo, J., Parodi, A. Absence of nucleoside diphosphatase activities in the yeast secretory pathway does not abolish nucleotide sugar-dependent protein glycosylation. J Biol Chem. 280: 40417-40427 (2005). PubMed
Caramelo, J., Castro, O., De Prat-Gay, G., Parodi, A. The endoplasmic reticulum glucosyltransferase recognizes nearly native glycoprotein folding intermediates. J Biol Chem. 279: 46280-46285 (2004). PubMed
Caramelo, J., Delfino, J. A subnanogram assay for phospholipase activity based on a long-chain radioiodinatable phosphatidylcholine. Anal Biochem. 333: 289-295 (2004). PubMed
Caramelo, J., Castro, O., Alonso, L., Prat-Gay, G.de, Parodi, A. UDP-Glc:glycoprotein glucosyltransferase recognizes structured and solvent accessible hydrophobic patches in molten globule-like folding intermediates. Proc Natl Acad Sci USA. 100: 86-91 (2003). PubMed
Caramelo, J., Florín-Christensen, J., Delfino, J. Phospholipase activity on N-acyl phosphatidylethanolamines is critically dependent on the N-acyl chain length. Biochem J. 374: 109-115 (2003). PubMed
Caramelo, J., Florín-Christensen, J., Florín-Christensen, M., Delfino, J. Mapping the catalytic pocket of phospholipases A2 and C with a novel series of radioiodinatable phosphatidylcholines. Biochem J. 346: 679-690 (2000). PubMed
Florín-Christensen, J., D´Alessio, C., Arighi, C., Caramelo, J., Florín-Christensen, M., Delfino, J. Micellar lipoproteins as the possible storage and translocation form of intracellular diacylglycerol. Biochem Biophys Res Commun. 243: 669-673 (1998). PubMed