Amilodiosis y Neurodegeneración
Jefe de Laboratorio: Dr. Eduardo Castaño
Publicaciones
Bulloj, A., Leal, M.C., Xu, H., Castaño, E.M., Morelli, L. Insulin-degrading enzyme sorting in exosomes: a secretory pathway for a key brain Aβ-degrading protease. J Alzheimer Dis. 19: 79-95 (2010). PubMed
Fernández-Gamba, A., Leal, M.C., Morelli, L., Castaño, E.M. Insulin-degrading enzyme: structure-function relationship and its possible roles in health and disease. Curr Pharm Des. 15: 3644-3655 (2009). PubMed
Llovera, R.E., de Tullio, M., Alonso, L.G., Leissring, M.A., Kaufman, S.B., Roher, A.E., de Prat Gay, G., Morelli, L., Castaño, E.M. The catalytic domain of insulin-degrading enzyme forms a denaturant-resistant complex with amyloid β peptide: Implications for Alzheimer's disease pathogenesis. J Biol Chem. 283: 17039-17048 (2008). PubMed
Van Vickle, G.D., Esh, C.L., Daugs, I.D., Kokjohn, T.A., Kalback, W.M., Patton, R.L., Luehrs, D.C., Walker, D.G., Lue, L.F., Beach, T.G., Davis, J., Van Nostrand, W.E., Castaño, E.M., Roher, A.E. Tg-SwDI transgenic mice exhibit novel alterations in AβPP Processing, Aβ degradation and a resilient amyloid angiopathy. Am J Pathol. 173: 483-493 (2008). PubMed
Bulloj, A., Leal, M.C., Surace, E.I., Zhang, X., Xu, H., Ledesma, M.D., Castaño, E.M., Morelli, L. Detergent resistant membrane-associated IDE in cultured cells and brain tissue: relevance to Aβ and insulin degradation. Mol Neurodegener. 3: 22 (2008). PubMed
Dorfman, V.B., Pasquini, L., Riudavets, M., Lopez-Costa, J.J., Villegas, A., Troncoso, J.C., Lopera, F., Castaño, E.M., Morelli, L. Differential cerebral deposition of IDE and NEP in sporadic and familial Alzheimer`s disease. Neurobiol Aging. (en prensa) (2008). PubMed